Deterioration of Esophageal Motility With Age: A Manometric Study of 79 Healthy Subjects

Grande, Luís; Lacima, Gloria; Ros, Emilio; Pera, Manuel; Ascaso, Carlos; Visa, Josep; Pera, Cristóbal

doi:10.1111/j.1572-0241.1999.01208.x

Cited by 121 publications

(69 citation statements)

References 29 publications

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“…Overall volume of the muscle tissue of the muscularis proper in the group of younger donors is larger than in the older group, but, again, the difference is not significant (less than 10%). This is in correlation with the findings of manometric studies that showed the lowering of the oesophageal peristaltic wave pressure with age [13,25]. The level of peristaltic wave reduction in their study is similar to the loss of overall muscle tissue volume that we found in the older group.…”

Section: Discussionsupporting

confidence: 91%

Morphometric analysis of muscularis proper and myenteric plexus of the normal human oesophagus. Age related changes

Milosavljević

Zelen²,

Tanasković³

et al. 2013

Folia Morphol

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Section: Discussionsupporting

confidence: 91%

Morphometric analysis of muscularis proper and myenteric plexus of the normal human oesophagus. Age related changes

Milosavljević

Zelen²,

Tanasković³

et al. 2013

Folia Morphol

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“…2,3 Several studies showed decreased sphincter relaxations and decreased esophageal contraction and dilatation in the aged people. [4][5][6] The neural control of gastrointestinal function, including esophageal motility is related to enteric neurons. 7,8 It has been shown that changes in esophageal physiology is associated with loss of esophageal myenteric plexus neurons, which are part of the enteric nervous system (ENS) and lie within the smooth muscle layers of the esophageal wall in the aged population.…”

Section: Introductionmentioning

confidence: 99%

Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Shim

Kim

Park

et al. 2017

J Neurogastroenterol Motil

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Background/AimsDisturbances of esophageal motility have been reported to be more frequent the aged population. However, the physiology of disturbances in esophageal motility during aging is unclear. The aim of this study was to evaluate the effects of age on esophageal motility using high-resolution esophageal impedance manometry (HRIM). MethodsEsophageal motor function of 268 subjects were measured using HRIM in 3 age groups, < 40 years (Group A, n = 32), 40-65 years (Group B, n = 185), and > 65 years (Group C, n = 62). Lower esophageal sphincter (LES) and upper esophageal sphincter (UES) pressures, integrated relaxation pressure, distal contractile integral, contractile front velocity, distal latency, and pressures and duration of contraction on 4 positions along the esophagus, and complete bolus transit were measured. ResultsBasal UES pressure was lower in Group C (P < 0.001) but there was no significant difference in the LES pressure among groups. Contractile duration on position 3 (10 cm from proximal LES high pressure zone) was longer in Group C (P = 0.001), and the contractile amplitude on position 4 (5 cm from proximal LES high pressure zone) was lower in Group C (P = 0.005). Distal contractile integral was lower in Group C (P = 0.037). Contractile front velocity (P = 0.015) and the onset velocity (P = 0.040) was lower in Group C. There was no significant difference in impedance values. ConclusionsThe decrease of UES pressure, distal esophageal motility, and peristaltic velocity might be related with esophageal symptoms in the aged population.

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“…Others have noted that simultaneous contractions are more likely to occur in older than in younger patients [13,14] , especially in the presence of severe GORD [15] . The effect of age in relation to the occurrence of simultaneous contractions in healthy volunteers, however, remains unclear, as one study revealed no relationship between simultaneous contractions and age [16] , whereas a more recent study did find a direct correlation between the proportion of simultaneous contractions and age [17] . The most recent study revealed differences in muscle thickness between similarly-categorized IOM subsets, and a significant correlation between muscle thickness, and the occurrence of simultaneous contractions [14] .…”

Section: Discussionmentioning

confidence: 99%

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

Haack¹,

Hansen²,

Malcolm³

et al. 2008

WJG

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AIM:To compare the demographic and clinical features of different manometric subsets of ineffective oesophageal motility (IOM; defined as ≥ 30% wet swallows with distal contractile amplitude < 30 mmHg), and to determine whether the prevalence of gastro-oesophageal reflux differs between IOM subsets. METHODS: Clinical characteristics of manometric subsets were determined in 100 IOM patients (73 female, median age 58 years) and compared to those of 100 age-and gender-matched patient controls with oesophageal symptoms, but normal manometry. Supine oesophageal manometry was performed with an eight-channel DentSleeve water-perfused catheter, and an ambulatory pH study assessed gastrooesophageal reflux. RESULTS: Patients in the IOM subset featuring a majority of low-amplitude simultaneous contractions (LASC) experienced less heartburn (prevalence 26%), but more dysphagia (57%) than those in the IOM subset featuring low-amplitude propagated contractions (LAP; heartburn 70%, dysphagia 24%; both P ≤ 0.01). LASC patients also experienced less heartburn and more dysphagia than patient controls (heartburn 68%, dysphagia 11%; both P < 0.001).The prevalence of heartburn and dysphagia in IOM patients featuring a majority of non-transmitted sequences (NT) was 54% (P = 0.04 vs LASC) and 36% (P < 0.01 vs controls), respectively. No differences in age and gender distribution, chest pain prevalence, acid exposure time (AET ) and symptom/reflux association existed between IOM subsets, or between subsets and controls. CONCLUSION: IOM patients with LASC exhibit a different symptom profile to those with LAP, but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibility of different pathophysiological mechanisms in IOM subsets, which warrants further investigation.

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Deterioration of Esophageal Motility With Age: A Manometric Study of 79 Healthy Subjects

Abstract: The results suggest that normal esophageal motility deteriorates with advancing age. Thus, age-related normality limits of esophageal pressures should be considered before establishing the manometric diagnosis of hypercontractile esophageal motility disorders.

Cited by 121 publications

References 29 publications

Morphometric analysis of muscularis proper and myenteric plexus of the normal human oesophagus. Age related changes

Morphometric analysis of muscularis proper and myenteric plexus of the normal human oesophagus. Age related changes

Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

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