The present work analyses the natural ventilation of a multi-span greenhouse with one roof vent and two side vents by means of sonic anemometry. Opening the roof vent to windward, one side vent to leeward, and the other side vents to windward (this last vent obstructed by another greenhouse), causes opposing thermal GT (m3 s−1) and wind effects Gw (m3 s−1), as outside air entering the greenhouse through the roof vent circulates downward, contrary to natural convection due to the thermal effect. In our case, the ventilation rate RM (h−1) in a naturally ventilated greenhouse fits a second order polynomial with wind velocity uo (RM = 0.37 uo2 + 0.03 uo + 0.75; R2 = 0.99). The opposing wind and thermal effects mean that ventilation models based on Bernoulli’s equation must be modified in order to add or subtract their effects accordingly—Model 1, in which the flow is driven by the sum of two independent pressure fields GM1=GT2±Gw2, or Model 2, in which the flow is driven by the sum of two independent fluxes GM2=GT±Gw. A linear relationship has been obtained, which allows us to estimate the discharge coefficient of the side vents (CdVS) and roof vent (CdWR) as a function of uo [CdVS = 0.028 uo + 0.028 (R2 = 0.92); CdWR = 0.036 uo + 0.040 (R2 = 0.96)]. The wind effect coefficient Cw was determined by applying models M1 and M2 proved not to remain constant for the different experiments, but varied according to the ratio uo/∆Tio0.5 or δ [CwM1 = exp(-2.693 + 1.160/δ) (R2 = 0.94); CwM2 = exp(−2.128 + 1.264/δ) (R2 = 0.98)].