Determinant of postprandial triglyceride levels in healthy young adults

Tarigan, Tri Juli Edi; Khumaedi, Anandhara Indriani; Wafa, Syahidatul; Johan, Michael; Abdullah, Murdani; Surono, Ingrid S.; Tahapary, Dicky L.

doi:10.1016/j.dsx.2019.04.027

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…Furthermore, the use of a 4-h postprandial value to de ne hypertriglyceridemia is consistent with practices reported by multiple authors in other countries [30][31][32][33]. A sutdy assessing the determinant of postprandial TG in healthy young adults found a strong correlation between 4 h postprandial TG and fasting TG and came to the conclusion that 4 h postprandial TG might potentially replace fasting TG when measurement of fasting TG is not feasible [34].…”

Section: Discussionsupporting

confidence: 83%

A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test

Hou

Guan

Tang

et al. 2021

Preprint

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Background: Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide. High postprandial serum lipid concentrations have been reported in patients with metabolic syndrome. Meanwhile, postprandial triglyceride (TG) was found to be a potential replacement when fasting TG is not available. We aimed to investigate the relationship between postprandial TG concentration during oral fat tolerance testing (OFTT) and NAFLD. Methods : A total of 472 Chinese adults, aged 25 to 65 years enrolled in this study. All the participants underwent OFTT. Serum triglyceride and other lipid concentrations were measured, and their relationships with NAFLD were analyzed. Results: Of the 472 participants, 155 were diagnosed with NAFLD. The fasting and postprandial TG concentrations of the participants with NAFLD were higher than those of healthy participants (P<0.05). The TG concentrations of the healthy participants peaked 4 h postprandially, whereas those of the participants with NAFLD peaked 6 h postprandially and had higher peak values. Postprandial triglyceride concentration showed significant association with higher risk of NAFLD.Conclusions: Higher postprandial TG concentration is positively related to higher risk of NAFLD, and postprandial TG concnetrations of NAFLD patients were higher than healthy individuals with a delayed peak time. Hence, 4h postprandial TG maybe a potential indicator for NAFLD.Trial registration number: ChiCTR1800019514

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Section: Discussionsupporting

confidence: 83%

A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test

Hou

Guan

Tang

et al. 2021

Preprint

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“…In this study, 4-h PTG is significantly related to NAFLD. The 4-h time point after eating is consistent with the results of a previous study that showed a strong correlation between 4-h PTG and fasting TG [26].…”

Section: Study Strength and Limitationssupporting

confidence: 91%

“…Furthermore, the use of a 4-h postprandial value to define hypertriglyceridemia is consistent with practices reported by multiple authors in other countries [ 22 – 25 ]. A study that assessed the determinants of PTG in healthy young adults found a strong correlation between 4-h PTG and fasting TG, and therefore the authors came to the conclusion that 4-h PTG might be suitable as a replacement for fasting TG when this cannot easily be measured [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test

et al. 2021

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Background Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide. Triglyceride (TG) accumulation is central to NAFLD development. People now spend most of their day in the postprandial state, and the measurement of postprandial blood lipid concentration can make up for the lack of simple detection of fasting blood lipids. Postprandial triglyceride (PTG) is commonly used as a surrogate for postprandial blood lipid concentrations, and many studies have shown that PTG is a risk factor for NAFLD. The aim of the present study was to investigate the relationship between PTG concentration during oral fat tolerance testing (OFTT) and NAFLD. Methods A total of 472 Chinese adults, aged 25 to 65 years, were enrolled in the study. All the participants underwent OFTT. The serum concentrations of TG and other lipids were measured, and their relationships with NAFLD were analyzed. Results Of the 472 participants, 155 were diagnosed with NAFLD. The fasting and postprandial TG concentrations of the participants with NAFLD were higher than those of healthy participants (P < 0.05). The TG concentrations of the healthy participants peaked 4 h postprandially, whereas those of the participants with NAFLD peaked 6 h postprandially and reached higher peak values. Postprandial TG concentration was significantly associated with a higher risk of NAFLD. Conclusions High PTG is positively related to a higher risk of NAFLD, and the PTG concentrations of patients with NAFLD are higher than in healthy individuals, with a delayed peak. Therefore, 4-h PTG may represent a potential marker of NAFLD. Trial registration ChiCTR1800019514.

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“…Although fasting triglycerides are a strong predictor of peak postprandial triglycerides, these mechanisms may explain why some have a disproportionately high triglyceride response following a meal. Furthermore, one or more of these processes are likely occurring in those who have elevated non-fasting/postprandial triglycerides ( 23 , 146 ) .…”

Section: Mechanisms and Pathophysiological Relevance Of High Non-fasting/postprandial Triglyceridesmentioning

confidence: 99%

Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk

et al. 2021

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Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible.

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Determinant of postprandial triglyceride levels in healthy young adults

Cited by 5 publications

References 16 publications

A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test

A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test

A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test

Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk

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