Determinants of, and reference equation for, exhaled nitric oxide in the Chinese population

Abstract

Measurement of fractional exhaled nitric oxide concentration (FeNO) has been proposed as a useful biomarker for monitoring and management of airway diseases. Limited information is available regarding reference levels of FeNO levels in Chinese adults. This study aimed to investigate the reference equation and determinants of FeNO in Chinese adults.1093 (577 males) healthy nonsmoking subjects aged 18-90 years were recruited. FeNO was measured online using a chemiluminescence analyser. Other assessments included spirometry, skin prick tests, total serum IgE levels and eosinophil count in peripheral blood.The geometric mean FeNO was 32.6 (95% reference interval (RI) 31. log(FeNO) 5 0.781 + 0.104(sex) + 0.004(age) + 0.084(atopy) + 0.003(height in cm), where for sex 15male and 05female, age is measured in years, for atopy 15atopic and 05nonatopic, and height is measured in cm.The FeNO of Chinese adults is higher than that of the Caucasian population, and is affected by age, sex, height and atopic status. This study provides useful references for the interpretation of FeNO. @ERSpublications Exhaled NO fraction in Chinese adults is higher than in Caucasians, and is affected by age, sex, height and atopy

Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

“…Atopy was not an independent determinant for FeNO levels in our study population in contrast to the results of previous studies 21,22,29. A previous study with the Korean population conducted by Kim et al15 in indicated that atopy (alongside gender) is a significant predictor of FeNO levels.…”

“…Our findings on gender association are consistent with those of previous reports15,19,20,21,22; however, mechanisms for the associations are unclear. A few hypotheses have been suggested in the literature.…”

“…Previous studies did not exclude subjects with BHR; subsequently, their FeNO levels may have been affected by subjects with asymptomatic BHR 15,19,22…”

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

“…The recruitment mode and adult age range were similar to previous studies having comparable aims to the present one [9, 10, 12, 14, 16, 20, 22]. …”

Ambient carbon monoxide associated with alleviated respiratory inflammation in healthy young adults

“…Within the normal FeNO levels, two studies in non-asthmatic children (mean age 9 yrs, average FeNO 15.1 ppb) and healthy non-smoking adults (aged 18e90, geometric mean of FeNO 32.6 ppb), respectively, showed that there were significant positive correlation between FeNO and percentage eosinophil counts in blood, an indicator of clinical inflammation level (Liu et al, 2014;Ko et al, 2013). The "protective" or "toxic" roles of CO might be determined by its levels.…”