Determinants of bisphenol A and phthalate metabolites in urine of Flemish adolescents

Geens, Tinne; Bruckers, Liesbeth; Covaci, Adrian; Schoeters, Greet; Fierens, Tine; Sioen, Isabelle; Vanermen, Guido; Baeyens, Willy; Morrens, Bert; Loots, Ilse; Nelen, Vera; Nemery, Benoît; Larebeke, N. Van; Hond, Elly Den

doi:10.1016/j.envres.2014.07.020

Cited by 50 publications

(42 citation statements)

References 43 publications

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“…However, the pvalue for the multiple test for association for daily smokers over the five periods based on Fisher's method for combining independent p-values is .04. This suggests an association between urinary BPA and smoking which is in accordance with some other reports (He et al, 2009;Arbuckle et al, 2015;Geens et al, 2014). It is not clear why the association did not hold when using number of cigarettes smoked over the previous five days but it is possible that smoking is a surrogate for some other type of behavior or demographic factor which would render the number of cigarettes smoked moot.…”

Section: Associations Between Bpa Exposure and Lifestyle/demographic/supporting

confidence: 88%

“…Various lifestyle, demographic and dietary factors have been reported to be associated with urinary BPA concentrations, including tobacco smoke exposure (Braun et al, 2011;Geens et al, 2014), family educational level (Covaci et al, 2015), canned foods (Covaci et al, 2015), household income (Geens et al, 2014;LaKind and Naiman, 2011), race/ethnicity, consumption of soda, school lunches and meals not prepared at home, and age and gender (LaKind and Naiman, 2011). Data on various demographic and lifestyle factors are available from NHANES.…”

Section: Introductionmentioning

confidence: 99%

“…(2) Do the five NHANES surveys provide evidence that previouslyidentified lifestyle/demographic/dietary factors associated with BPA exposures (Braun et al, 2011;Covaci et al, 2015;Geens et al, 2014;LaKind and Naiman, 2011) are consistently observed? We explore consistency of associations across the five surveys using urinary BPA concentration data (volumebased and creatinine-adjusted).…”

Section: Introductionmentioning

confidence: 99%

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Temporal trends in bisphenol A exposure in the United States from 2003–2012 and factors associated with BPA exposure: Spot samples and urine dilution complicate data interpretation

LaKind

Naiman

2015

Environmental Research

114

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Nationally representative data on urinary levels of BPA and its metabolites in the United States from the 2003-2004 to 2011-2012 National Health and Nutrition Examination Surveys (NHANES) were used to estimate daily BPA intakes and examine temporal trends. Additionally, NHANES data on lifestyle/demographic/dietary factors previously reported to be associated with BPA exposures were examined to assess the resiliency of the reported associations (whether the association is maintained across the five surveys). Finally, various approaches for addressing issues with the use of BPA concentration data from spot urine samples were examined for their effect on trends and associations. Three approaches were assessed here: (i) use of generic literature-based 24-h urine excretion volumes, (ii) use of creatinine adjustments, and (iii) use of individual urine flow rate data from NHANES. Based on 2011-2012 NHANES urinary BPA data and assumptions described in this paper, the median daily intake for the overall population is approximately 25 ng/kg day; median intake estimates were approximately two to three orders of magnitude below current health-based guidance values. Estimates of daily BPA intake have decreased significantly compared to those from the 2003-2004 NHANES. Estimates of associations between lifestyle/demographic/dietary factors and BPA exposure revealed inconsistencies related to both NHANES survey year and the three approaches listed above; these results demonstrate the difficulties in interpreting urinary BPA data, despite efforts to account for urine dilution and translation of spot sample data to 24-h data. The results further underscore the importance of continued research on how to best utilize urinary measures of environmental chemicals in exposure research. Until a consensus is achieved regarding the best biomonitoring approaches for assessing exposures to short-lived chemicals using urine samples, research on factors associated with BPA exposures should include - and report results from - assessments using both volume-based urinary BPA and creatinine-adjusted urinary BPA data.

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Section: Associations Between Bpa Exposure and Lifestyle/demographic/supporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Temporal trends in bisphenol A exposure in the United States from 2003–2012 and factors associated with BPA exposure: Spot samples and urine dilution complicate data interpretation

LaKind

Naiman

2015

Environmental Research

114

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“…Thus the high percentage of subjects with non-detectable BPA could be explained, at least in part, by geographical location. Additional factors known to affect BPA exposure include time from last meal and smoking (Braun et al 2011a; Geens et al 2014; He et al 2009). Very few subjects (<2%) in this study were smokers and we lack information on fasting time, so we could not determine whether non-detectable BPA correlated with either of these factors.…”

Section: Discussionmentioning

confidence: 99%

Prenatal bisphenol A exposure and maternally reported behavior in boys and girls

et al. 2014

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Prenatal exposure to gonadal hormones plays a major role in the normal development of the male and female brain and sexually dimorphic behaviors. Hormone-dependent differences in brain structure and function suggest that exposure to exogenous endocrine disrupting chemicals may be associated with sex-specific alterations in behavior. Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways. Epidemiological and experimental studies suggest associations between prenatal exposure to BPA and child behavior, however data are inconsistent, and few studies have examined school age children. We examined BPA concentration in spot urine samples from women at mean 27 weeks of pregnancy in relation to child behavior assessed at age 6-10 years using the parent-completed Child Behavior Checklist (CBCL). We report associations between maternal BPA urinary concentrations and several CBCL scores in 153 children (77 boys, 76 girls). We observed a significant interaction between maternal urinary BPA and sex for several behaviors (externalizing, aggression, Anxiety Disorder, Oppositional/Defiant Disorder and Conduct Disorder traits), but no significant associations between BPA and scores on any CBCL scales. However in analyses restricted to children of mothers with detectable prenatal urinary BPA (n=125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys. In addition we observed a significant interaction between BPA and sex for several behaviors (externalizing, withdrawn/depressed, rule-breaking, Oppositional/Defiant Disorder traits, and Conduct Disorder traits). These results suggest that prenatal exposure to BPA may be related to increased behavior problems in school age boys, but not girls.

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“…Many analytical procedures have been proposed for the determination of EDC biomarkers, mostly using urine as the matrix. While a few studies used blood serum, plasma, and breast milk, there have not been many studies using human saliva as the analytical matrix.…”

Section: Introductionmentioning

confidence: 99%

Determination of 15 Biomarkers of Endocrine Disrupting Chemicals in Human Saliva by Gas Chromatography–Mass Spectrometry

Lim

Shin

2020

Bulletin Korean Chem Soc

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A sensitive method was developed to simultaneously determine 15 biomarkers of endocrine disrupting chemicals (EDCs) in human saliva using dispersive liquid-liquid microextraction (DLLME) and gas chromatography-mass spectrometry. This study also confirmed that the phthalate diesters were converted by glucuronidase/aryl sulfatase to their respective primary metabolites -mono-esters, but not to the secondary metabolites. The amount of 100 μL β-glucuronidase/aryl sulfatase hydrolyzed about 95% of the phthalate diesters (500 μg/L) within 3 h. The problems of hydrolysis of phthalate diesters by β-glucuronidase/aryl sulfatase are discussed. Ethyl acetate and acetonitrile were selected as extraction and disperser solvents in DLLME, and then the extracts were subjected to derivatization with N-methyl-N-(tert-bultyl dimethyl silyl) trifluoroacetamide directly without concentration after extraction. After optimizing the required conditions, good linearity of analytes was achieved. The limit of detection (LOD) and the limit of quantification (LOQ) were in the ranges of 0.015-3.0 μg/L and 0.05-10 μg/L, respectively.

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Determinants of bisphenol A and phthalate metabolites in urine of Flemish adolescents

Cited by 50 publications

References 43 publications

Temporal trends in bisphenol A exposure in the United States from 2003–2012 and factors associated with BPA exposure: Spot samples and urine dilution complicate data interpretation

Temporal trends in bisphenol A exposure in the United States from 2003–2012 and factors associated with BPA exposure: Spot samples and urine dilution complicate data interpretation

Prenatal bisphenol A exposure and maternally reported behavior in boys and girls

Determination of 15 Biomarkers of Endocrine Disrupting Chemicals in Human Saliva by Gas Chromatography–Mass Spectrometry

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