Determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7 years follow-up

Meani, Paolo; Maloberti, Alessandro; Scocco, Paola; Colombo, Giulia; Giupponi, Luca; Stucchi, Miriam; Varrenti, Marisa; Vallerio, Paola; Facchetti, Rita; Grassı, Guıdo; Mancia, Giuseppe; Giannattasio, Cristina

doi:10.1080/08037051.2017.1378069

Cited by 38 publications

(16 citation statements)

References 31 publications

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“…None of the participants had a diastolic blood pressure above 90 mmHg. Blood pressure is included in the examination of PWV and AIX, and is an important predictor of increasing PWV in follow-up studies [35]. Significant differences in some of the lipid biomarker concentrations were seen between males and females (CHOL and Apo B/Apo A-1 ratio).…”

Section: Resultsmentioning

confidence: 99%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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Background: Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. Methods: Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses. Results: The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS. Conclusions: A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.

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Section: Resultsmentioning

confidence: 99%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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“…There are likely to be a number of factors contributing to age-related WMH progression. Meani et al (2018) observed the largest increase in pulse wave velocity (PWV), a measure of carotid stiffness, in the seventh decade [ 45 ]. PWV increased 1.8 m/s over an average of 3.7 years in individuals between 61 and 70.…”

Section: Discussionmentioning

confidence: 99%

Cardiorespiratory fitness diminishes the effects of age on white matter hyperintensity volume

et al. 2020

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White matter hyperintensities (WMHs) are among the most commonly observed marker of cerebrovascular disease. Age is a key risk factor for WMH development. Cardiorespiratory fitness (CRF) is associated with increased vessel compliance, but it remains unknown if high CRF affects WMH volume. This study explored the effects of CRF on WMH volume in community-dwelling older adults. We further tested the possibility of an interaction between CRF and age on WMH volume. Participants were 76 adults between the ages of 59 and 77 (mean age = 65.36 years, SD = 3.92) who underwent a maximal graded exercise test and structural brain imaging. Results indicated that age was a predictor of WMH volume (beta = .32, p = .015). However, an age-by-CRF interaction was observed such that higher CRF was associated with lower WMH volume in older participants (beta =-.25, p = .040). Our findings suggest that higher levels of aerobic fitness may protect cerebrovascular health in older adults.

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“…Evidence available to date would indicate that traditional risk factors, such as BMI, age, BP, homocysteine levels and serum lipids have strong associations with the progressions of PWV and IMT. For example, Meani et al [13] enrolled 333 hypertensive outpatients and followed 3.7 years, and showed that age, baseline BP were independent predictors of ΔPWV. Similarly, Huang et al [37] analyzed the data from 712 stroke-free and myocardial infarction-free Chinese participants at baseline and after an average interval of 4.3 years.…”

Section: Discussionmentioning

confidence: 99%

Predictors for progressions of brachial–ankle pulse wave velocity and carotid intima–media thickness over a 12-year follow-up

Wang

Yuan

Gao

et al. 2019

Journal of Hypertension

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Objective: Atherosclerotic diseases are the leading cause of death worldwide. This study aimed to investigate the predictors of brachial–ankle pulse wave velocity (baPWV) and carotid intima–media thickness (CIMT) progression in a Chinese cohort over a 12-year follow-up period and to determine whether these predictors differ by follow-up time. Methods: A total of 202 participants were recruited from a previously established cohort in Shaanxi Province, China. Both baPWV and CIMT were measured in 2013 and 2017. Multivariable regression was used to determine the predictors of CIMT and baPWV progression. Results: Men had higher CIMT and baPWV and a higher rate of CIMT progression during two follow-ups than women. A 4-year change in SBP was associated with baPWV progression, whereas a 12-year change in DBP was associated with baPWV progression. The increased progression of baPWV presented a linear trend when subgrouping all the participants according to SBP and DBP changes over 4 and 12 years, respectively. In addition, heart rate (HR) change over 4 and 12 years was consistently associated with CIMT progression, and a linear trend was also seen when subgrouping the population. Conclusion: Our study demonstrated that SBP and DBP contributed differently in different stages to the progression of arterial stiffness in this Chinese cohort. Moreover, HR was consistently involved in the increased progression of CIMT in all periods. These findings underline the importance of early detection and control of blood pressure and resting HR for the prevention of arterial stiffness progression.

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Determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7 years follow-up

Abstract: the accelerated arterial aging in treated hypertensive subjects is in large measure explained by age and BP values. PWV changes over time would probably give important information that need further future research studies.

Cited by 38 publications

References 31 publications

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Cardiorespiratory fitness diminishes the effects of age on white matter hyperintensity volume

Predictors for progressions of brachial–ankle pulse wave velocity and carotid intima–media thickness over a 12-year follow-up

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