Determinants of disability in cervical dystonia

Dool, J. van den; Tijssen, Marina A. J.; Koelman, J.H.T.M.; Engelbert, R.H.H.; Visser, Bart

doi:10.1016/j.parkreldis.2016.08.014

Cited by 66 publications

(61 citation statements)

References 23 publications

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“…In CD patients, psychiatric features and pain are important determinants of disability. Interventions to reduce psychiatric problems and pain should have a more prominent role in the treatment of CD patients in order to improve disability levels 19. Health-related quality of life (HRQoL) is a useful evaluation of general well-being of patients with regard to physical health, mental state, and social function.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

Kongsaengdao¹,

Maneeton²,

Maneeton³

2017

NDT

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ObjectiveThis study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients.Materials and methodsA 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes’ 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period.ResultsA total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P<0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P>0.05).ConclusionCD patients’ disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved.

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Section: Introductionmentioning

confidence: 99%

Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

Kongsaengdao¹,

Maneeton²,

Maneeton³

2017

NDT

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“…In another recent large study on QoL of 96 CD patients, five components (disability, psychiatric features, pain, physical function, and severity of dystonia) explained 74.4% of the variance in disability. Psychiatric features had the largest contribution to disability, followed by pain, physical functioning, and severity of dystonia which had no significant contribution [29].…”

Section: Psychiatric Disorders and Quality In Life In Dystonia Patientsmentioning

confidence: 93%

“…Depression, along with the anxiety spectrum, is the most reported psychiatric disorder in the primary/isolated dystonia population. Depression is highly reported in CD patients, most often in the diapason from 25 [26,27] to 47% [28,29], and that might be due to the fact that this is the most frequent form of isolated dystonia. Lifetime and point prevalence of major depression are increased.…”

Section: Epidemiological and Etiological Basismentioning

confidence: 99%

Non-Motor Symptoms in Patients with Primary Dystonia

Semerdjieva¹,

Milanov²

2018

Dystonia - Different Prospects

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Isolated dystonia, previously referred to as primary, is the third most common movement disorder, characterized by involuntary muscle contractions causing abnormal movements and postures with or without the presence of tremor. No matter monogenic or sporadic, the form of dystonia is a growing evidence, suggesting the presence of non-motor components to the disorder. Dystonia patients suffer from reduced quality of life, which might be related not only to the dystonic movements itself but to different non-motor symptoms and signs, as well. Based on literature review, this chapter aims to focus on the association of different types of isolated/primary dystonia (forms of focal, segmental, and generalized dystonia) with some non-motor disorders, including sleep and psychiatric disorders, cognition, as though as pain and sensory symptoms, their pathophysiological and biochemical mechanisms, relations with the symptomatic treating strategies for the abnormal movements, and specific treatment for the non-motor signs.

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“…Самая высокая коморбидность с психическими расстройствами отмечена у больных с цервикальной дистонией. Частота выявления этих расстройств у больных с цервикальной дистонией составляет от 64 до 91% по сравнению с 28-35% у здоровых [6,[55][56][57]. Депрессия при данной форме дистонии встречается у 15-53% пациентов, тревога -у 24-83% [55,56].…”

Section: психические нарушенияunclassified

Non-motor disorders in patients with muscular dystonia

Salouchina¹,

Nodel

Толмачева

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Минздрава России, Москва, Россия; 3 ФГБОУ ВО «Российский национальный медицинский исследовательский университет им. Н.И. Пирогова. Научно-клинический геронтологический центр» Минздрава России, Москва, Россия Недвигательные расстройства у пациентов с мышечной дистонией (МД) представлены сенсорными, аффективными, обсессивно-компульсивными нарушениями, когнитивной дисфункцией, расстройствами сна. Клиническая значимость этих нарушений у пациентов с МД определяется их распространенностью и негативным влиянием на качество жизни больных. Распространенность сенсорных, аффективных нарушений, расстройств сна превышает 50% у больных с цервикальной дистонией и 25%-у больных с блефароспазмом, писчим спазмом; когнитивная дисфункция выявляется более чем у 25% больных с фокальной МД. Показана связь недвигательных, в частности психических, нарушений со снижением социальной, бытовой активности и ухудшением качества жизни больных с МД. Обсуждаются возможные патофизиологические механизмы и подходы к терапии недвигательных симптомов при МД. Приводятся данные о положительном влиянии ботулинотерапии, сопровождающейся уменьшением когнитивной дисфункции, выраженности сенсорных нарушений, проявлений депрессивного синдрома. Рассматриваются методы немедикаментозного воздействия на недвигательные расстройства у пациентов с МД.

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Determinants of disability in cervical dystonia

Cited by 66 publications

References 23 publications

Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

Non-Motor Symptoms in Patients with Primary Dystonia

Non-motor disorders in patients with muscular dystonia

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