Aim. To study the indicators and regional specifics of morbidity associated with temporary disability in the Subjects of the Far Eastern Federal District (FEFD) of Russia.Materials and methods. A descriptive epidemiological study was performed based on retrospective data on the morbidity associated with temporary disability of the working population in FEFD as of January 01, 2021. A unified inter-agency information and statistical system was used to study the indicators of temporary disability (TD), including the number of TD cases per 100 employees and the number of TD days per 100 employees during 2005–2020. The methods of descriptive statistics were applied to differentially calculate the average annual indicators for the periods of 2005–2014 and 2015–2019 due to the adoption of the Rosstat order No. 723 dated December 25, 2014.Results. The average long-term value of the indicators of morbidity associated with temporary disability in most FEFD subjects was found to be statistically significantly higher than that in the entire Russian Federation, with higher values o bserved in 2005–2014 compared to 2015–2019. The indicators of morbidity associated with temporary disability demonstrated a more stable trend during 2015–2019. The indicators for 2020 were statistically higher than for 2015–2019, largely due to the COVID-19 pandemics.Conclusions. In view of the specific nature of the main economic sectors in FEFD (shift and seasonal work), as well as the lack of a developed social, road transport, and engineering infrastructure, data on temporary disability of the working population (including migrants) should be continuously monitored. The results obtained at this research stage can be used to develop optimal measures aimed at protecting the health of people living in the Far East of Russia.