Determinants of long-term quality of life in patients with differentiated thyroid carcinoma – a population-based cohort study in Sweden

Hedman, Christel; Djärv, Therese; Strang, Peter; Lundgren, Catharina Ihre

doi:10.3109/0284186x.2015.1102965

Cited by 74 publications

(59 citation statements)

References 22 publications

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“…The findings of the current study have provided new insights into the relationship between thyroid cancer survivorship and QOL. Although QOL is an important area of research, prior studies have been discordant regarding the association between thyroid cancer history and QOL . In our analytic sample, only patients who overestimated their mortality risk demonstrated a meaningful decrease in physical QOL compared with the general population, although the decrease was no longer statistically significantly different from that of the general US population when we excluded patients who self‐reported a history of depression.…”

Section: Discussionmentioning

confidence: 84%

“…Although QOL is an important area of research, prior studies have been discordant regarding the association between thyroid cancer history and QOL. [6][7][8] In our analytic sample, only patients who overestimated their mortality risk demonstrated a meaningful decrease in physical QOL compared with the general population, although the decrease was no longer statistically significantly different from that of the general US population when we excluded patients who selfreported a history of depression. This suggests that a better understanding of risk perception is an important aspect of helping to understand QOL among survivors of thyroid cancer.…”

Section: Discussionmentioning

confidence: 87%

“…Worry regarding disease recurrence and death is common among patients with thyroid cancer . However, to the best of our knowledge, there is a lack of data regarding the relationship between risk estimation and worry in survivors of thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28] Worry regarding disease recurrence and death is common among patients with thyroid cancer. 5,6 However, to the best of our knowledge, there is a lack of data regarding the relationship between risk estimation and worry in survivors of thyroid cancer. Consistent with studies in the breast cancer literature, we found that patients who overestimated their risks of recurrence and mortality were more likely to report cancer-related worry.…”

Section: Discussionmentioning

confidence: 99%

“…Despite having an excellent prognosis, prior work has shown that patient worry regarding disease recurrence and death is common, with underrepresented minority groups especially at risk . In addition, there are conflicting data concerning patient quality of life (QOL), with some studies finding that patients with thyroid cancer have a worse QOL compared with those with melanoma, colorectal cancer, and the general population, and other studies reporting that their QOL is similar to that of healthy patients without cancer . To the best of our knowledge, the reasons for the discordance between patient prognosis and patient worry and QOL remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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Disparities in risk perception of thyroid cancer recurrence and death

Chen

Reyes‐Gastelum

Wallner

et al. 2019

Cancer

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Background To the authors' knowledge, studies regarding risk perception among survivors of thyroid cancer are scarce. Methods The authors surveyed patients who were diagnosed with differentiated thyroid cancer from the Surveillance, Epidemiology, and End Results registries of Georgia and Los Angeles County (2632 patients; 63% response rate). The analytic cohort was defined by a ≤5% risk of disease recurrence and mortality (1597 patients). Patients estimated their recurrence and mortality risks separately (increments of 10% and endpoints of ≤5% and ≥95%). Both outcomes were dichotomized between reasonably accurate estimates (risk perception of ≤5% or 10%) versus overestimation (risk perception of ≥20%). Multivariable logistic regression was used to identify factors associated with risk overestimation, and the relationships between overestimation and both worry and quality of life were evaluated. Results In the current study sample, 24.7% of patients overestimated their recurrence risk and 12.5% overestimated their mortality risk. A lower educational level was associated with overestimating disease recurrence (≤high school diploma: odds ratio [OR], 1.64 [95% CI, 1.16‐2.31]; and some college: OR, 1.36 [95% CI, 1.02‐1.81]) and mortality (≤high school diploma: OR, 1.86 [95% CI, 1.18‐2.93]) risk compared with those attaining at least a college degree. Hispanic ethnicity was found to be associated with overestimating recurrence risk (OR, 1.44, 95% CI 1.02‐2.03) compared with their white counterparts. Worry about recurrence and death was found to be greater among patients who overestimated versus those who had a reasonably accurate estimate of their risk of disease recurrence and mortality, respectively (P < .001). Patients who overestimated mortality risk also reported a decreased physical quality of life (mean T score, 43.1; 95% CI, 41.6‐44.7) compared with the general population. Conclusions Less educated patients and Hispanic patients were more likely to report inaccurate risk perceptions, which were associated with worry and a decreased quality of life.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Disparities in risk perception of thyroid cancer recurrence and death

Chen

Reyes‐Gastelum

Wallner

et al. 2019

Cancer

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Papillary Thyroid Microcarcinoma—If It Is Such a Good Cancer, Why Operate?

Sawka

Goldstein

2019

JAMA Otolaryngol Head Neck Surg

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The quality of life in papillary thyroid microcarcinoma patients undergoing lobectomy or total thyroidectomy: A cross‐sectional study

et al. 2021

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Objective Papillary thyroid microcarcinoma (PTMC) has a good prognosis and a long survival time, surgery is the common treatment including total thyroidectomy (TT) and unilateral lobectomy (LT), but recent studies showed that TT does not show an advantage over LT for PTMC in preventing cancer recurrence and reducing mortality. Given this, the health‐related quality of life (HRQoL) has become one of the important factors that physicians must consider when making treatment decisions. The aim of this study was to compare the HRQoL of patients between undergoing TT and LT. Methods From October 2019 to December 2019, 69 PTMC patients were enrolled in our study, including 34 in the LT group and 35 in the TT group, respectively. We used three questionnaires which included the 36‐item short‐form health survey (SF‐36), thyroid cancer‐specific quality of life (THYCA‐QOL), and Fear of Progression Questionnaire‐Short Form (FoP‐Q‐SF) for each patient to evaluate their scores of HRQoL. Results According to the SF‐36, the scores of the domain for the role limitation due to physical problems, emotional problems, and social function (RP, RE, and SF) as well as Physical Component Summary (PCS) and Mental Component Summary (MCS) showed a significant negative linear association between the LT group and TT group: RP (coefficient [coef]: −33.953 [confidence interval (CI) −51.187 to −16.720], p < 0.001, RE (coef: −21.633 [CI −39.500 to −3.766], p = 0.018), SF (coef: −10.169 [CI −19.586 to −0.752], p = 0.035)and PCS (coef: −10.571 [CI −17.768 to −3.373], p = 0.005), MCS (coef: −10.694 [CI −19.465 to −1.923], p = 0.018). The THYCA‐QOL showed that the scores of the TT group were higher than that of the LT group in the problem of scar (coef: 16.245 [CI 1.697 to 30.794], p = 0.029 according to the multivariate analysis), suggesting a higher level of complaint in the TT group. There was no statistically significant difference in the scores of FoP‐Q‐SF between the two groups. Conclusions In patients with PTMC, LT offers an advantage over TT in terms of HRQoL, which supports the role of LT as an alternative strategy to TT.

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Determinants of long-term quality of life in patients with differentiated thyroid carcinoma – a population-based cohort study in Sweden

Cited by 74 publications

References 22 publications

Disparities in risk perception of thyroid cancer recurrence and death

Disparities in risk perception of thyroid cancer recurrence and death

Papillary Thyroid Microcarcinoma—If It Is Such a Good Cancer, Why Operate?

The quality of life in papillary thyroid microcarcinoma patients undergoing lobectomy or total thyroidectomy: A cross‐sectional study

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