Determinants of plasma retinol, β-carotene, and α-tocopherol during adolescence

Herbeth, Bernard; Spyckerelle, Y; Deschamps, J. P.

doi:10.1093/ajcn/54.5.884

Cited by 29 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vitamin A has also been correlated in a direct, linear way with plasma concentrations of total lipids among the group of children with IDDM (n ¼ 47, r ¼ 0.36, P < 0.02). Herbeth et al (1991) obtained similar results in healthy children aged 10 -15 y. These results suggest that RBP performs a protective function in situations of hypertriglyceridemia or atherogenic risk, perhaps in order to improve the transport of retinol (diminished) as an antioxidant to where it is required, or perhaps for some other important, but as yet unknown, function.…”

Section: Influence Of Metabolic Control Of the Illness On Atherogenicsupporting

confidence: 59%

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

et al. 2002

View full text Add to dashboard Cite

Objective: A case -control study was conducted to evaluate the effects of type 1 diabetes mellitus (IDDM) on plasma levels of vitamin A (retinol) and serum levels of retinol-binding protein (RBP) and their relationship with the atherogenic indicators. Subjects: A total of 47 randomised IDDM children were recruited from those treated at the Endocrinology Unit of the University Hospital of Granada (Spain). They were matched for age and sex with 16 healthy children. Methods: The following parameters were measured in all patients: serum concentrations of total cholesterol, triglycerides, high (HDL, spectrophotometry), very low (VLDL) and low (LDL) density lipoprotein cholesterol (Friedewald's formula); serum levels of RBP (kinetic nephelometry); plasma vitamin A and glycosilated haemoglobin (HbA1c; high performance chromatography). Results: Higher RBP concentrations in IDDM children (P ¼ 0.05), lower retinol levels (P ¼ 0.05) and lower vitamin A=cholesterol ratio (P ¼ 0.02) than in the control group were found; no differences in the atherogenic indicators were observed. There was a correlation between RBP and vitamin A (P ¼ 0.0001). Relationships between retinol, RBP and atherogenic indicators were demonstrated in the IDDM group (A-LDLc=HDLc (P ¼ 0.01); A-(VLDL þ LDL)c=HDLc (P ¼ 0.007); RBP-LDLc=HDLc (P ¼ 0.05); RBP-(VLDL þ LDL)c=HDLc (P ¼ 0.02)), and an inverse relationship was found between the vitamin A=TG ratio and HbA1c (P ¼ 0.004). The children with HbA1c > 8% showed increased atherogenic indicators and lower vitamin A=CHOL and vitamin A=TG ratios than those with good control of the illness. Conclusions: The IDDM children with poor metabolic control face a higher atherogenic risk and vitamin A 'relative deficiency' risk than those with good metabolic control of their illness. Relationships between retinol and RBP with atherogenic indicators were found. The results suggest that vitamin A therapeutic supplements in IDDM children may reduce or prevent atherogenic risk.

show abstract

Section: Influence Of Metabolic Control Of the Illness On Atherogenicsupporting

confidence: 59%

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

et al. 2002

View full text Add to dashboard Cite

show abstract

“…This increase probably reflects larger liver vitamin A stores that reflect normal physiological changes with growth and does not necessarily indicate better vitamin A status with ageing. Plasma concentrations of retinol and RBP increase greatly during adolescence (particularly during puberty) with the degree of sexual maturation in boys and girls, even after adjusting for plasma cholesterol and TAG concentrations (Herbeth et al, 1991). Consequently, by using single cutoff points of plasma retinol concentration for all ages (eg 0.70-1.05 mmol/l), there is a greater likelihood of those aged 4-6 y being falsely considered to have suboptimal vitamin A status compared with those aged 15-18 y.…”

Section: Discussionmentioning

confidence: 99%

Zinc and vitamin A intake and status in a national sample of British young people aged 4–18 y

2004

View full text Add to dashboard Cite

Objective: To examine zinc and vitamin A intake and status and associated dietary, socio-demographic, lifestyle and physiological factors in British young people. Design: National Diet and Nutrition Survey of young people aged 4-18 y. Setting: Great Britain, 1997. Subjects: Complete 7-day weighed dietary records were provided by 1520 participants, while 1193 provided blood samples. Results: A total of 13 and 11% of participants respectively reported low dietary intakes of zinc and vitamin A (retinol equivalents), relative to the UK lower reference nutrient intake. These percentages were not altered significantly by including contributions to intake from supplements, mainly containing vitamin A (as retinol). Likelihood of low zinc and/or vitamin A intake was more often associated with age, sex and likely under-reporting of food consumption than with other sociodemographic and lifestyle factors. Low zinc and vitamin A intakes were generally less likely in those with higher consumption of dairy foods (mainly milk). Zinc and vitamin A status (assessed by plasma zinc and retinol concentrations) were adequate in almost all participants. Plasma zinc concentration was not significantly associated with zinc intake. Plasma retinol concentration was correlated with vitamin A intake (overall r ¼ 0.17, Po0.001; adjusted for age and plasma a 1 -antichymotrypsin concentration) and increased significantly with age (Po0.001) in both sexes. A significant association was found between plasma zinc and retinol concentrations in boys only (r ¼ 0.17, P ¼ 0.001). Conclusion: Zinc and vitamin A intakes and status were generally adequate in this national sample of British young people. Sponsorship:Food Standards Agency, UK.

show abstract

“…It is well documented that the growth velocity during adolescence is slower in undernourished populations (Eveleth and Tanner, 1990), giving rise to cephalopelvic disproportion which, in the adolescents who become pregnant, is related to increased maternal and foetal mortality (Harrison et al, 1985). It has also been suggested that iron is an essential nutrient for skeletal growth (Herbeth et al, 1991) and, thus, iron de®ciency may be a limiting factor for growth during adolescence (Brabin and Brabin, 1992). In Bangladesh, almost a quarter of the total population are adolescents.…”

Section: Introductionmentioning

confidence: 99%

Anaemia and iron deficiency among adolescent schoolgirls in peri-urban Bangladesh

et al. 2000

View full text Add to dashboard Cite

Objective: To investigate the prevalence of anaemia and iron de®ciency among adolescent schoolgirls in periurban Bangladesh, and to identify various factors associated with anaemia in this population. Design: A cross-sectional design. Setting: Girls' high schools in ®ve sub-districts of Dhaka. Subjects: Adolescent girls (n 548) aged 11 ± 16 y from nine schools in Dhaka district participated in the study. Socio-economic, anthropometric and dietary information were collected. Blood haemoglobin (Hb), serum iron, total iron binding capacity (TIBC), transferrin saturation (TS), serum ferritin (SF) and serum retinol (vitamin A) were determined. Results: The prevalence of anaemia (Hb`120 gal) among the participants was 27%. Seventeen percent had depleted iron stores (SF`12 mgal). Of all anaemic girls, 32% had iron de®ciency anaemia (Hb`120 gal and SF`12 mgal). When the girls were classi®ed by serum vitamin A, the third with the lowest serum retinol levels had signi®cantly lower Hb and SF levels. Signi®cant positive correlations were observed between Hb and serum iron, TS, SF and retinol, while there was a negative correlation with serum TIBC. Occupancy, frequency of consumption of large ®sh, serum iron, TIBC, TS, SF and serum vitamin A were strongly related to Hb by multiple regression analysis. For 1 mgal change in SF concentration, there was a 0.046 gal change in Hb, when adjusted for all other factors. Conclusion: Anaemia among these adolescent schoolgirls in peri-urban Bangladesh cannot be explained by iron de®ciency alone, and other causes may also exist in this population. Descriptors: iron de®ciency; anaemia; adolescent girls; serum ferritin; serum vitamin A

show abstract

Determinants of plasma retinol, β-carotene, and α-tocopherol during adolescence

Cited by 29 publications

References 28 publications

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

Zinc and vitamin A intake and status in a national sample of British young people aged 4–18 y

Anaemia and iron deficiency among adolescent schoolgirls in peri-urban Bangladesh

Contact Info

Product

Resources

About