Objective: A case -control study was conducted to evaluate the effects of type 1 diabetes mellitus (IDDM) on plasma levels of vitamin A (retinol) and serum levels of retinol-binding protein (RBP) and their relationship with the atherogenic indicators. Subjects: A total of 47 randomised IDDM children were recruited from those treated at the Endocrinology Unit of the University Hospital of Granada (Spain). They were matched for age and sex with 16 healthy children. Methods: The following parameters were measured in all patients: serum concentrations of total cholesterol, triglycerides, high (HDL, spectrophotometry), very low (VLDL) and low (LDL) density lipoprotein cholesterol (Friedewald's formula); serum levels of RBP (kinetic nephelometry); plasma vitamin A and glycosilated haemoglobin (HbA1c; high performance chromatography). Results: Higher RBP concentrations in IDDM children (P ¼ 0.05), lower retinol levels (P ¼ 0.05) and lower vitamin A=cholesterol ratio (P ¼ 0.02) than in the control group were found; no differences in the atherogenic indicators were observed. There was a correlation between RBP and vitamin A (P ¼ 0.0001). Relationships between retinol, RBP and atherogenic indicators were demonstrated in the IDDM group (A-LDLc=HDLc (P ¼ 0.01); A-(VLDL þ LDL)c=HDLc (P ¼ 0.007); RBP-LDLc=HDLc (P ¼ 0.05); RBP-(VLDL þ LDL)c=HDLc (P ¼ 0.02)), and an inverse relationship was found between the vitamin A=TG ratio and HbA1c (P ¼ 0.004). The children with HbA1c > 8% showed increased atherogenic indicators and lower vitamin A=CHOL and vitamin A=TG ratios than those with good control of the illness. Conclusions: The IDDM children with poor metabolic control face a higher atherogenic risk and vitamin A 'relative deficiency' risk than those with good metabolic control of their illness. Relationships between retinol and RBP with atherogenic indicators were found. The results suggest that vitamin A therapeutic supplements in IDDM children may reduce or prevent atherogenic risk.

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Background: Exposures to agrochemicals can be directly through the handling of chemicals as well as indirectly when consuming food containing residues of them. Such exposure may affect the health of the population if accumulated in the human body, including in human milk. Objective: This literature review aims to assess the potential impact of agrochemical residues in human milk as a barrier for breastfeeding. Method: The search followed PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta Analyses), by selecting original articles published between 1995 and 2019, extracted from the free access databases PubMed, Scielo, Web of Sciences and Scopus using as key words: agrochemicals, pesticides, breastfeeding, human milk, contamination and infant. Medical Subject Headings (MeSH) were used as descriptors. Results: We selected 11 studies. Taking as inclusion criteria those most aligned with the objective of our study. Conclusion: The studies presented in this review ratified the benefits of breastfeeding compensate the potential risks of agrochemicals residues in human milk.

Objetivo: Evaluar el impacto educativo en pacientes con Diabetes Mellitus tipo 2 (DMT2) e Hipertensión arterial (HTA), y su efecto en la calidad de vida. Métodos: Se realizó un estudio intervención en comunidad, en pacientes con diagnóstico de DMT2 e HTA, en la consulta de Medicina Interna. Resultados: Participaron 314 pacientes, distribuidos en un grupo estudio (n = 160) y grupo control (n = 154). Sin diferencias en edad (p = 0,491) y sexo (p = 0,747). En la calidad de vida de pacientes DM entre pre y post charla, en cada grupo, sin diferencias entre grupos en pre-charla (p = 0,869), pero sí en post-charla (p = 0,001), siendo calidad de vida más alta en el grupo estudio (98,2%) que en grupo control (76,9%). Al evaluar los cambios entre pre y post charla, se observó que pre charla en el grupo estudio tuvo 86% de alta calidad de vida, posterior aumentó a 98,2%, cambio estadístico (p = 0,008), en grupo control en cambio, la calidad de vida pre charla fue 87% pasó a 76,9% posterior a ésta, aun así, fue un cambio significativo (p = 0,025) La calidad de vida en HTA, sin diferencias en pre y post charla. La comparación entre pre charla y post charla, en el grupo estudio, no tuvo cambios (p = 0,157) como igualmente en el grupo control (p = 0,317). Conclusiones: Se demostró el impacto positivo de un plan educativo en calidad de vida de los pacientes con diabetes, mas no en pacientes hipertensos.