Determinants of portal hypertensive gastropathy reconsidered

Das, Ananya; Ghoshal, Uday C.

doi:10.1016/0016-5085(92)91472-g

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Accordingly, we prospectively studied PHG in children with extrahepatic portal venous obstruction (EHPVO) with variceal bleed before EIS and after esophageal variceal obliteration with the following aims: (a) to determine the frequency and severity of PHG in children with EHPVO, and (b) to find out the role of EIS and H. pylori infection in causing PHG. Extrahepatic portal venous obstruction is associated with normal functional status of the liver; the contribution of the progressive liver cell failure in causing PHG is eliminated in our study (7).…”

mentioning

confidence: 52%

“…Further, the study showed increased frequency of PHG among cirrhotics with poor liver functions (class C) than in patients with preserved liver functions (class A) (6). However, in this study, the contribution of esophageal variceal obliteration by EIS in causing PHG is controversial because no consideration was given to the progressive deterioration of the functional status of liver during the long follow‐up period (7). Progressive deterioration of liver functions is well known in cirrhotic patients, and increase in PHG on long‐term follow‐up could very well be due to this factor.…”

Section: Discussionmentioning

confidence: 97%

“…Factors influencing development of PHG are controversial. In a large series in adults, esophageal variceal obliteration achieved by endoscopic injection sclerotherapy (EIS) has been claimed to increase the incidence of PHG (6); however, this study has been questioned in view of absence of data regarding progression of the child's status over a long follow‐up period (7). There are a few studies addressing the role of Helicobacter pylori (H. pylori) in causing PHG in adults (8‐12) and none in children.…”

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confidence: 99%

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Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

Yachha,

Ghoshal,

Gupta

et al. 1996

J. pediatr. gastroenterol. nutr.

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SummaryWe aimed to determine the frequency of portal hypertensive gastropathy (PHG) in children with extrahepatic portal venous obstruction (EHPVO) and to find out the role of esophageal variceal obliteration by endoscopic injection sclerotherapy (EIS) and Helicobacter pylori (H. pylori) infection in the pathogenesis of PHG. Twenty consecutive children were studied before EIS and 20 after esophageal varices obliteration. Diagnosis of PHG was established by endoscopic assessment. Helicobacter pylori infection was diagnosed by rapid urease test, H. pylori culture, smear, and histopathologic examination of antral biopsy specimens. Portal hypertensive gastropathy was characterized and graded by endoscopy according to previously established criteria. In the pre‐EIS group, eight (40%) had PHG (mild in all) compared with 16 (80%; mild in eight, severe in eight) in the post‐EIS group (p < 0.05). Portal hypertensive gastropathy was more extensive in the post‐EIS group. There was no significant difference between frequency of gastric varices and H. pylori infection in the pre‐EIS and post‐EIS groups. We conclude that PHG is common in children with EHPVO; its frequency, extent, and severity increase after esophageal variceal obliteration by EIS, and H. pylori infection does not play any role in its development.

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confidence: 52%

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

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Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

Yachha,

Ghoshal,

Gupta

et al. 1996

J. pediatr. gastroenterol. nutr.

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Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

Yachha

Ghoshal²,

Gupta³

et al. 1996

Journal of Pediatric Gastroenterology & Nutrition

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We aimed to determine the frequency of portal hypertensive gastropathy (PHG) in children with extrahepatic portal venous obstruction (EHPVO) and to find out the role of esophageal variceal obliteration by endoscopic injection sclerotherapy (EIS) and Helicobacter pylori (H. pylori) infection in the pathogenesis of PHG. Twenty consecutive children were studied before EIS and 20 after esophageal varices obliteration. Diagnosis of PHG was established by endoscopic assessment. Helicobacter pylori infection was diagnosed by rapid urease test, H. pylori culture, smear, and histopathologic examination of antral biopsy specimens. Portal hypertensive gastropathy was characterized and graded by endoscopy according to previously established criteria. In the pre-EIS group, eight (40%) had PHG (mild in all) compared with 16 (80%; mild in eight, severe in eight) in the post-EIS group (p < 0.05). Portal hypertensive gastropathy was more extensive in the post-EIS group. There was no significant difference between frequency of gastric varices and H. pylori infection in the pre-EIS and post-EIS groups. We conclude that PHG is common in children with EHPVO; its frequency, extent, and severity increase after esophageal variceal obliteration by EIS, and H. pylori infection does not play any role in its development.

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Determinants of portal hypertensive gastropathy reconsidered

Cited by 2 publications

References 3 publications

Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

Portal Hypertensive Gastropathy in Children with Extrahepatic Portal Venous Obstruction: Role of Variceal Obliteration by Endoscopic Sclerotherapy and Helicobacter pylori Infection

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