Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study

Glynn, Anders; Aune, Marie; Darnerud, Per Ola; Cnattingius, Sven; Bjerselius, Rickard; Becker, Wulf; Lignell, Sanna

doi:10.1186/1476-069x-6-2

Cited by 107 publications

(87 citation statements)

References 30 publications

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“…Older age predicted higher serum PCB levels. This is consistent with what other researchers have noted as indicative of the accumulation of exposure (Furberg et al, 2002) and/or a cohort effect whereby younger women have less exposure to PCB because of decreasing PCB use and levels in the environment (Glynn et al, 2007). Lopez-Carrillo et al (2001) found that breast-feeding is a route for the excretion of metabolites and that 1-2 years of lactation could reduce DDE serum levels in mothers by 50%.…”

Section: Discussionsupporting

confidence: 78%

“…In our study, the number of total months that a woman had breast-fed her children was also inversely associated with serum PCB levels, consistent with this route as an efficient means of excretion from the mother but a substantial source of exposure for the infant. Some studies have found an inverse association between pre-pregnancy BMI and serum PCB levels in pregnant women (James et al, 2002;Glynn et al, 2007). Glynn et al (2007) attribute this to a dilution effect associated with the rapid weight gain during pregnancy, which might be greater in those with high BMI to begin with.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have found an inverse association between pre-pregnancy BMI and serum PCB levels in pregnant women (James et al, 2002;Glynn et al, 2007). Glynn et al (2007) attribute this to a dilution effect associated with the rapid weight gain during pregnancy, which might be greater in those with high BMI to begin with. Furberg et al (2002) found a positive association between serum concentration of PCB and BMI in middle-aged women.…”

Section: Discussionmentioning

confidence: 99%

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Serum PCB concentrations in relation to locally produced food items in eastern Slovakia

Sonneborn

Park

Babinská

et al. 2008

J Expo Sci Environ Epidemiol

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Ingestion has been a primary route of PCB exposure for people, especially those not working directly in industrial settings. During 2002During -2004 were recruited at delivery from two districts in eastern Slovakia: Michalovce with high PCB contamination from a chemical manufacturing plant, and Svidnik located 70 km to the northwest, having lower environmental levels of PCBs. Concentrations of 15 PCB congeners were measured in maternal serum using high-resolution gas chromatography with electron capture detection. A food frequency questionnaire was developed and validated at the Research Institute of Nutrition and School of Medicine in Bratislava, Slovakia. The questionnaire was comprised of 88 food items representative of the national dietary habits and designed to ascertain (1) the source of food items as reported by the women (locally produced or purchased from a retail outlet) and (2) quantities consumed of high-fat food categories representative of the national dietary habits. Our primary goal was to identify specific food sources, either locally produced or purchased from retail stores, that might predict serum concentrations of PCBs. We used multiple linear regression to examine the relationship of dietary fats to lipid-adjusted serum PCB levels in 948 adult women (Michalovce N ¼ 662, Svidnik N ¼ 284) who had recently given birth. We adjusted for residential district, age, body mass index, education and duration of previous lactation. Consumption of fat from locally produced foods was significantly associated with higher levels of lipid-adjusted serum PCB (b ¼ 0.06, P ¼ 0.007). Fat from foods purchased in retail outlets showed no significant association (b ¼ À0.02, P ¼ 0.36). There was no interaction between district and diet in predicting serum PCB levels. Comparing women in Michalovce consuming 20 g of fat per day from local sources with those consuming 1 g of fat per day from local sources, lipidadjusted serum concentrations were predicted to be higher by 81 ng/g lipid or 14.8% 630 ng/g lipid versus 549 ng/g lipid.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum PCB concentrations in relation to locally produced food items in eastern Slovakia

Sonneborn

Park

Babinská

et al. 2008

J Expo Sci Environ Epidemiol

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“…Huisman et al (1995) indicated this as one of the reasons why food intake explained only a small fraction of the variance of cord blood PCB and dioxin levels in 355 women. Recently, Glynn et al (2007) found OC levels measured in Swedish pregnant women, were indeed influenced by fatty fish consumption years before pregnancy, namely during adolescence. We noticed that significantly more residents from rural areas reported consumption of local diary products (25%) and of locally produced animal fat (41%) compared with the whole population (respectively 13% and 17%).…”

Section: Determinants Of Pollutant Levels In Cord Bloodmentioning

confidence: 98%

Organochlorine and heavy metals in newborns: Results from the Flemish Environment and Health Survey (FLEHS 2002–2006)

Koppen

Hond

Nelen

et al. 2009

Environment International

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a b s t r a c t a r t i c l e i n f oTo collect regional information on internal levels of pollutants in humans in Flanders, 1196 mother-child pairs were systematically recruited in 2002-2003 via 25 maternities across Flanders. Cd, Pb, PCB congeners 118, 170, 138, 153 and 180, p,p′-DDE -a key metabolite of DDT-and hexachlorobenzene (HCB) were measured in cord blood or plasma. Cd was detected in 64% of the samples (geometric mean 0.21 µg/L cord blood). p,p′-DDE (110 ng/g plasma lipids) and Pb (14.7 µg/L blood), were measurable in nearly all samples. The individual PCB congeners could be detected in 40 to 81% of the newborns (138 + 153 + 180 = 64.4 ng/g plasma lipids). HCB (18.9 ng/g plasma lipids) and dioxin-like compounds measured by DR-CALUX® (23 pg CALUX-TEQ/g lipids) were above detection limit in more than 75% of the samples. Age and smoking habits of the mothers, did not influence the cord blood Pb and Cd levels. The organochlorines increased 4 to 9% per year of the mother's age (partial R 2 = 0.05 to 0.22). Mothers had 2.6% less PCBs in cord blood (partial R 2 = 0.02) for each unit increase in pre-pregnancy BMI. Season of delivery, breastfeeding previous children or consumption of local dairy products, were minor determinants. Up to 20% of the variability in organochlorine concentrations was explained by residence area. It was concluded that the place of birth in Flanders is an important determinant of the load of pollutants measured at the start of life. This underlines the validity of human biomonitoring on (relatively) small geographical scale.

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“…Age was a significant determinant of serum concentration of chlorinated pesticides in this study. Glynn et al (2007) also reported another serum concentration of the general Swedish population (Glynn et al, 2007). The serum of 323 pregnant primiparous women living in Uppsala county (age 18-41 years) sampled in 1996-1999.…”

Section: Levels In the European Population 441 Swedenmentioning

confidence: 99%

Organochlorine Pesticides in Human Serum

Kang¹,

Chang²

2011

Pesticides - Strategies for Pesticides Analysis

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Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study

Cited by 107 publications

References 30 publications

Serum PCB concentrations in relation to locally produced food items in eastern Slovakia

Serum PCB concentrations in relation to locally produced food items in eastern Slovakia

Organochlorine and heavy metals in newborns: Results from the Flemish Environment and Health Survey (FLEHS 2002–2006)

Organochlorine Pesticides in Human Serum

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