Determinants of spirometric abnormalities among silicotic patients in Hong Kong

Leung, Chi Chiu; Chang, Kwok Chiu; Law, Wing Sze; Yew, Wing Wai; Tam, Cheuk Ming; Chan, Chi Kuen; Wong, M

doi:10.1093/occmed/kqi107

Cited by 21 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, a history of TB was also associated with COPD. Previous studies from Africa and Asia have consistently shown a positive association between pulmonary TB and airflow obstruction 28–34 . Results from the PLATINO study in Latin America showed that subjects with a history of TB were more than twice as likely to present with airflow obstruction than those without TB, even after adjustment for confounding by age, gender, smoking and environmental exposures.…”

Section: Discussionmentioning

confidence: 92%

Burden of obstructive lung disease in a rural setting in the Philippines

Idolor¹,

Guia

Francisco

et al. 2011

Respirology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 92%

Burden of obstructive lung disease in a rural setting in the Philippines

Idolor¹,

Guia

Francisco

et al. 2011

Respirology

View full text Add to dashboard Cite

show abstract

“…Patients with previous pulmonary TB were more likely to suffer from acute exacerbation of COPD than those who did not have pulmonary TB (15). In silicosis patients, history of TB is an independent predictor of airflow obstruction (16). The bronchodilator response of patients with a tuberculous-destroyed lung is lower than that of patients with COPD (17).…”

Section: Discussionmentioning

confidence: 99%

The Risk of Obstructive Lung Disease by Previous Pulmonary Tuberculosis in a Country with Intermediate Burden of Tuberculosis

Lee

Kim

et al. 2011

J Korean Med Sci

View full text Add to dashboard Cite

We evaluated the effects of previous pulmonary tuberculosis (TB) on the risk of obstructive lung disease. We analyzed population-based, the Second Korea National Health and Nutrition Examination Survey 2001. Participants underwent chest X-rays (CXR) and spirometry, and qualified radiologists interpreted the presence of TB lesion independently. A total of 3,687 underwent acceptable spirometry and CXR. Two hundreds and ninty four subjects had evidence of previous TB on CXR with no subjects having evidence of active disease. Evidence of previous TB on CXR were independently associated with airflow obstruction (adjusted odds ratios [OR] = 2.56 [95% CI 1.84-3.56]) after adjustment for sex, age and smoking history. Previous TB was still a risk factor (adjusted OR = 3.13 [95% CI 1.86-5.29]) with exclusion of ever smokers or subjects with advanced lesion on CXR. Among never-smokers, the proportion of subjects with previous TB on CXR increased as obstructive lung disease became more severe. Previous TB is an independent risk factor for obstructive lung disease, even if the lesion is minimal and TB can be an important cause of obstructive lung disease in never-smokers. Effort on prevention and control of TB is crucial in reduction of obstructive lung disease, especially in countries with more than intermediate burden of TB.

show abstract

“…Tuberculosis is an important cause of morbidity and mortality among silicotic patients [5] and both smoking and tuberculosis are independently associated with lung function impairment [28]. Smoking cessation is, therefore, expected to have major impact on the quality of life for patients suffering from this largely irreversible disease.…”

Section: Discussionmentioning

confidence: 99%

Smoking and tuberculosis among silicotic patients

Leung¹,

Yew²,

Law³

et al. 2006

Eur Respir J

View full text Add to dashboard Cite

The aim of the present study was to investigate the relationship between smoking and tuberculosis (TB) among high-risk silicotic patients in Hong Kong.A cohort of 435 silicotic patients tuberculin tested from 1995-2002 was prospectively followedup until the end of 2005. Baseline characteristics were analysed with respect to positive tuberculin reaction (o10 mm) at baseline and subsequent development of TB.Smoking, alcohol use and body mass index were independent predictors of positive tuberculin reaction at baseline in multiple logistic regression analysis. Total cigarette pack-yrs did not demonstrate any significant effect. The annual incidences of TB were 1,841, 2,294 and 4,181 per 100,000 for never-, ex-and current smokers, respectively. On Cox proportional hazard analysis, current smokers have a significantly higher risk of TB than other silicotic patients (adjusted hazard ratio (95% confidence interval (CI)): 1.96 (1.14-3.35)) after controlling for age, alcohol use, tuberculin status, treatment for latent TB infection and other relevant background/disease factors. A significant dose-response relationship was also observed with the daily number of cigarettes currently smoked. Smoking cessation may reduce 32.4% (95% CI: 6.5-54.0) of the risk.Smoking increases the risk of both tuberculosis infection and subsequent development of the disease among silicotic patients.

show abstract

Determinants of spirometric abnormalities among silicotic patients in Hong Kong

Abstract: In an occupational compensation setting, disease indices and history of tuberculosis are independent predictors of both airflow obstruction and reduced vital capacity for silicotic patients.

Cited by 21 publications

References 0 publications

Burden of obstructive lung disease in a rural setting in the Philippines

Burden of obstructive lung disease in a rural setting in the Philippines

The Risk of Obstructive Lung Disease by Previous Pulmonary Tuberculosis in a Country with Intermediate Burden of Tuberculosis

Smoking and tuberculosis among silicotic patients

Contact Info

Product

Resources

About