Determinants of uterine aging: lessons from rodent models

Kong, Shuangbo; Zhang, Shuang; Chen, YongJie; Wang, Weixiang; Wang, BingYan; Chen, Qi; Duan, Enkui; Wang, Haibin

doi:10.1007/s11427-012-4356-1

Cited by 24 publications

(24 citation statements)

References 79 publications

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“…It has been observed in animal models that elasticity and tonicity of uterine tissues are gradually reduced as the female ages and this change is directly related with the increase of collagen protein content in uterine tissue; likewise, it is know that ES stimulate collagen deposits throughout the reproductive life of the female (Mulholland & Jones, 1993;Kong et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Histometric Parameters of Uterus and Vagina in Breeder Female Rabbits on the Day After Weaning According to the Ordinal Number of Parturitions

et al. 2014

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SUMMARY:The objective of this study was to establish in New Zealand female rabbits, the effect of ordinal number of parturitions on some histological parameters on the day after weaning. Tissue fragments of uterus and vagina were obtained from females of first, second and third parturitions and were processed imbedding them in paraffin in order to do histological cuts. In eight microscope fields captured by a camera connected to an optic microscope, the lumen and glandular endometrial epithelium height, as well as the thickness of vaginal and myometrium epithelium thickness were measured. From the results that were obtained it was concluded that there are significant differences (p<0.05) in histological parameters evaluated in uterus and vagina between does of different parturitions, which indicates that the number of parturitions has an effect on histometric characteristics of genital tract organs in breeder female rabbits.

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Section: Discussionmentioning

confidence: 99%

Histometric Parameters of Uterus and Vagina in Breeder Female Rabbits on the Day After Weaning According to the Ordinal Number of Parturitions

et al. 2014

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“…; Kong et al . ). Increased rates of resorption of conceptuses and intrauterine fetal deaths, as well as stillbirth rates, have also been reported in ageing rodents (Talbert, ; Holinka et al .…”

Section: Discussionmentioning

confidence: 97%

Effect of reproductive ageing on pregnant mouse uterus and cervix

Patel

Moffatt

Mourmoura

et al. 2017

The Journal of Physiology

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Key points Older pregnant women have a greater risk of operative delivery, still birth and post‐term induction.This suggests that maternal age can influence the timing of birth and processes of parturition.We have found that increasing maternal age in C57BL/6J mice is associated with prolongation of gestation and length of labour.Older pregnant mice also had delayed progesterone withdrawal and impaired myometrial function.Uterine ageing and labour dysfunction should be investigated further in older primigravid women. AbstractAdvanced maternal age (≥35 years) is associated with increased rates of operative delivery, stillbirth and post‐term labour induction. The physiological causes remain uncertain, although impaired myometrial function has been implicated. To investigate the hypothesis that maternal age directly influences successful parturition, we assessed the timing of birth and fetal outcome in pregnant C57BL/6J mice at 3 months (young) and 5 months (intermediate) vs. 8 months (older) of age using infrared video recording. Serum progesterone profiles, myometrium and cervix function, and mitochondrial electron transport chain complex enzymatic activities were also examined. Older pregnant mice had a longer mean gestation and labour duration (P < 0.001), as well as reduced litter size (P < 0.01) vs. 3‐month‐old mice. Older mice did not exhibit the same decline in serum progesterone concentrations as younger mice. Cervical tissues from older mice were more distensible than younger mice (P < 0.05). Oxytocin receptor and connexin‐43 mRNA expression were reduced in the myometrium from 8‐month‐old vs. 3‐month‐old mice (P < 0.05 and P < 0.01 respectively) in tandem with more frequent but shorter duration spontaneous myometrial contractions (P < 0.05) and an attenuated contractile response to oxytocin. Myometrial mitochondrial copy number was reduced in older mice, although there were no age‐induced changes to the enzymatic activities of the mitochondrial electron transport chain complexes. In conclusion, 8‐month‐old mice provide a useful model of reproductive ageing. The present study has identified potential causes of labour dysfunction amenable to investigation in older primigravid women.

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“…The immune system undergoes considerable maturation (Rothkötter et al, 2002); gonadal steroid and other hormonal systems become more active (Nugent et al, 2012); changes occur in brain stem-spinal cord connections, which influence pain processing (Hathway et al, 2009); and the gastrointestinal system matures, influencing digestion and absorption of nutrients (Klein, 1986). For example, aging is associated with diminished immune function (Chinn et al, 2012;Molano et al, 2012); joint mobility declines due to loss of viscoelasticity in the chondrocytes (Duan et al, 2012); the ability to detect and eliminate cancerous cells diminishes (de Magalhães, 2013); and reproductive function declines (Kong et al, 2012). These developmental changes can profoundly impact research results.…”

Section: B Agementioning

confidence: 99%