Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

Palacios, Cristina; Gil, Karen M.; Pérez, Cynthia M.; Joshipura, Kaumudi

doi:10.1159/000335282

Cited by 31 publications

(23 citation statements)

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“…These findings are similar to those of a recent study of a convenience sample of 98 obese and overweight Puerto Rican adults without asthma, of whom 45% had vitamin D levels less than 30 ng/ml (28). The estimated prevalence of vitamin D insufficiency in children with asthma in Puerto Rico (a Caribbean island) is thus markedly higher than that reported for children with asthma living in Costa Rica (a Central American nation, 28%), and underscores the potential significance of vitamin D insufficiency on asthma morbidity in residents of areas with year-round sun exposure or near the Equator.…”

Section: Discussionsupporting

confidence: 89%

Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children

Brehm

Acosta‐Pérez

Klei³

et al. 2012

Am J Respir Crit Care Med

200

168

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Rationale: Vitamin D insufficiency (a serum 25(OH)D ,30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin D and asthma in Puerto Ricans. Objectives: To examine whether vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, and time outdoors. Methods: A cross-sectional study was conducted of 560 children ages 6-14 years with (n ¼ 287) and without (n ¼ 273) asthma in San Juan, Puerto Rico. We measured plasma vitamin D and estimated the percentage of African racial ancestry among participants using genomewide genotypic data. We tested whether vitamin D insufficiency is associated with severe asthma exacerbations, lung function, or atopy (greater than or equal to one positive IgE to allergens) using logistic or linear regression. Multivariate models were adjusted for African ancestry, time outdoors, atopy, and other covariates. Measurements and Main Results: Vitamin D insufficiency was common in children with (44%) and without (47%) asthma. In multivariate analyses, vitamin D insufficiency was associated with higher odds of greater than or equal to one severe asthma exacerbation in the prior year (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.5-4.9; P ¼ 0.001) and atopy, and a lower FEV 1 /FVC in cases. After stratification by atopy, the magnitude of the association between vitamin D insufficiency and severe exacerbations was greater in nonatopic (OR, 6.2; 95% CI, 2-21.6; P ¼ 0.002) than in atopic (OR, 2; 95% CI, 1-4.1; P ¼ 0.04) cases. Conclusions: Vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, or markers of disease severity or control.Keywords: vitamin D; asthma exacerbations; Puerto Ricans; childhood Vitamin D insufficiency (a serum level of 25(OH)D ,30 ng/ml) is common among children in the United States mainland. For example, a nationwide study of 2,759 U.S. children ages 6-11 years found vitamin D insufficiency in approximately 62% of nonHispanic whites, approximately 86% of Hispanics, and approximately 96% of non-Hispanic blacks (1). Vitamin D insufficiency has been associated with increased asthma morbidity, particularly severe disease exacerbations, in observational studies of children of school age in Costa Rica (2) and North America (3).Although current evidence from observational (2-5) and experimental studies (6-9) suggests that vitamin D insufficiency leads to severe asthma exacerbations or increased asthma morbidity in childhood (10), no study of vitamin D and asthma morbidity has accounted for objectively assessed racial ancestry and time spent outdoors. This is critical to exclude whether vitamin D insufficiency is associated with severe asthma exacerbations or asthma morbidity through "reverse causation" (e.g., more severe asthma leading to reduced time outdoors and thus decreased exposure to sunlight ...

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Section: Discussionsupporting

confidence: 89%

Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children

Brehm

Acosta‐Pérez

Klei³

et al. 2012

Am J Respir Crit Care Med

200

168

View full text Add to dashboard Cite

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“…The present study showed that higher BMI is associated with lower basal 25OHD in the sample as a whole. This is consistent with the reported in the literature negative association between 25OHD levels and obesity [59][60][61][62][63][64][65][66]. This effect was not evident for each gender group; this may be due to a small sample size in each group.…”

Section: Vitamin D Deficiency and Night Shift Work O R I G I N A L P supporting

confidence: 92%

Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect

Alefishat¹,

Farha²

2016

Int J Occup Med Environ Health

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Objectives: To assess the association between night work and 25-hydroxy vitamin D (25OHD) levels, and to evaluate effect of potential risk factors on 25OHD levels. Material and Methods: A total of 140 adult Jordanian employees were recruited. Demographic, lifestyle and working patterns data were documented through a well-structured questionnaire. Vitamin D status was assessed by measuring circulating concentrations of 25OHD. Results: Mean 25OHD level was 23.8 ng/ml. No significant difference was found in 25OHD levels between the summer and winter (p = 0.46), or between males and females (p = 0.35). The female night workers had significantly lower serum 25OHD levels compared to the female day workers (p = 0.01). No significant difference in serum 25OHD levels was found between the night and day male workers (p = 0.25). The number of night shifts/month was negatively correlated with 25OHD levels in both the males and females (p = 0.01 and p = 0.007, respectively). Age was positively correlated with 25OHD levels in both the males and females (p = 0.02 and p = 0.001, respectively). Body mass index was negatively associated with 25OHD levels in the whole sample (p = 0.03), but not within each gender group (p = 0.21 for the males and p = 0.09 for the females). Smoking had no significant association with 25OHD levels (p = 0.99 for the males and p = 0.22 for the females). Conclusions: Our results suggest that women working night shifts are at higher risk of 25OHD deficiency, and, consequently, of other health problems linked to 25OHD deficiency. Int J Occup Med Environ Health 2016;29(5):859-870

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“…Although the island of Puerto Rico (PR) is located in a tropical region, to our knowledge there are only two recently published studies addressing vitamin D levels in Puerto Ricans. 29–30 The first 29 was a cross-sectional study consisting of 1,292 Puerto Rican adults (379 men and 913 women, ranging in age from 45 to 75 years) and showed geometric means for plasma 25(OH)D concentrations of 15.8±1.5 ng/ml for men and 16.0±1.5 ng/ml for women. According to these results, 68.6% of the participating men and 65.5% of the participating women were deficient (cutoff of <20 ng/ml).…”

mentioning

confidence: 99%

Importance of Vitamin D and Vitamin D levels Status in Puerto Ricans

Suarez-Martinez¹,

Pérez²,

Cruz³

et al. 2013

hpu

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There is growing and compelling evidence demonstrating the extra-skeletal role of vitamin D and the importance of maintaining adequate levels of this nutrient. Currently, there is very limited information available on the vitamin D status in children and adults in underserved groups, including Puerto Ricans. We assessed the vitamin D status of 4,090 Puerto Ricans living in six geographical regions in the island. Only 31.5% of the studied population had sufficient vitamin D levels (>30 ng/ml). The 18–39 year age group and the females showed inadequate (<30 ng/ml) levels of vitamin D (76.9% and 69.8%, respectively). Participants aged 60 or older showed the highest mean values of serum 25(OH)D (28.8 ng/ ml) and the highest percentage (37.1%) of suffi cient levels (>30 ng/ml). Future studies are certainly warranted to understand the prevalence of vitamin D deficiency and influencing factors (including obesity) in Puerto Ricans.

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Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

Cited by 31 publications

References 100 publications

Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children

Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children

Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect

Importance of Vitamin D and Vitamin D levels Status in Puerto Ricans

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