Determination and Correlation of the Solubility of <scp>l</scp>-Fucose in Four Binary Solvent Systems at the Temperature Range from 288.15 to 308.15 K

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The mole fraction solubility data of N-acetyl-dl-methionine in 16 pure solvents at T = 283.15–323.15 K were measured using the static gravimetric method under a pressure of 98.8 kPa. The polymorphism of N-acetyl-dl-methionine was studied by X-ray powder diffraction analysis, and the results show that there may exist two polymorphs in the studied solid–liquid equilibrium systems. The solubility increased with increasing temperature, and the largest solubility value was obtained in methanol, followed by ethanol > n-propanol > isopropanol > n-butanol > sec-butanol > isobutanol > n-pentanol > acetone > 2-butanone > water > methyl acetate > ethyl acetate > dichloromethane (except for 1,4-dioxane and acetonitrile, which intersect with other solvents). The above solubility behavior is affected by the mutual constraints of polarity, hydrogen bonding, cohesive energy density, viscosity, and molecular structure. In addition, the KAT-LSER model was applied to analyze solute–solvent and solvent–solvent intermolecular interactions. To mathematically represent the measured solubility data, the modified Apelblat model and Yaws model were employed. The average relative deviation (ARD), root-mean-square deviation (RMSD), Akaike information criterion (AIC), and Akaike values of each model were calculated to evaluate the fitting outcomes.

Section: Methodsmentioning

confidence: 90%

Solubility Behavior and Polymorphism of N-Acetyl-dl-methionine in 16 Individual Solvents from 283.15 to 323.15 K

Huang

Qiu

et al. 2021

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“…All the chemicals were used without any further treatment. A static gravimetric method, − was used for determining the solubility of l -thioproline in the selected solvent systems. The detailed experimental procedures are described in the Supporting Information file.…”

Section: Methodsmentioning

confidence: 99%

“…The crystal form of the raw l -thioproline and equilibrated solids in different solvents were identified by the powder X-ray diffraction (PXRD), which was carried out on the X-ray diffractometer (PANalytical B.V. X’Pert PRO MPD, Netherlands) with Cu Kα radiation (1.5406 Å) at a scanning rate of 10°/min. The voltage and current of the tube were set as 40 kV and 150 mA, respectively, and the tested range was from 5 to 60 ° (2θ degree).The details for preparing the samples is the same as that in our previous works. , …”

Section: Methodsmentioning

confidence: 99%

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Solid–Liquid Equilibrium of l-Thioproline in Nine Neat Solvents and Water + Acetonitrile Binary Solvent System from 283.15 to 323.15 K: Solubility Determination and Data Modeling

Qiu

Wang

et al. 2021

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The data on the solubility of L-thioproline in a mole fraction scale in nine individual solvents (water, methanol, ethanol, isopropanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and 1,4-dioxane) and one binary solvent mixture of water + acetonitrile was measured by a static gravimetric method from 283.15 to 333.15 K. Whether or not a neat or binary solvent system is used, the solubility is nonlinearly positively correlated with the experimental temperatures. At a given temperature, the solubility presents an order of water > acetone ≈ 1,4-dioxane > dichloromethane ≈ ethanol ≈ ethyl acetate > methanol > isopropanol > acetonitrile, which is a result of the multiple influences of many factors related to intermolecular interactions. Four thermodynamic models, including the modified Apelblat, Yaws, Jouyban−Acree, and Apelblat−Jouyban−Acree models were employed for correlating the solubility data, and the results show a satisfactory fitting effect for each model.

“…The temperature dependence of the solubility was correlated by a modified Apelblat equation (eq ), which is derived from the van’t Hoff isochore by assuming that the apparent partial molar enthalpy of the solute is a linear function of temperature. − x is the molar solubility of lanosterol in the solvent, and A , B , and C are fitting parameters.…”

Section: Data Correlationmentioning

confidence: 99%

Solubility of Lanosterol in Organic Solvents and in Water–Alcohol Mixtures at 101.8 kPa

Forciniti

2020

Lanosterol is a sterol derivative whose physicochemical properties are poorly understood. Pure lanosterol (>95%) was isolated from a crude product (54.6%) by a newly developed C18 reverse-phase high-performance liquid chromatography (HPLC) method. Purity and structure were confirmed by gas chromatography–mass spectrometry (GC–MS). The melting temperature and fusion enthalpy were determined to be 408.27 K and 23.61 kJ/mol, respectively. The solubility of lanosterol was measured in methanol, ethanol, isopropanol, n-propanol, acetonitrile, acetone, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ethyl acetate, water, water–methanol, water–isopropanol, and water–ethanol binary systems using a static equilibrium setup from 277.09 to 338.78 K. The solid phases were characterized by X-ray diffraction and by scanning differential calorimetry. The solubility of lanosterol increases with an increase in temperature. The mole fraction of lanosterol in organic solvents has a minimum of 3.0 × 10–5 in methanol at 277.78 K and a maximum of 0.0048 in n-propanol at 318.93 K. The solubilities of lanosterol in organic solvents were correlated by the modified Apelblat equation and by the Wilson, NRTL, and UNIQUAC models. Furthermore, the binary water–alcohol systems were correlated by the Apelblat–Jouyban–Acree and the van’t Hoff–Jouyban–Acree models.