Determination and Correlation of the Solubility of l -Cysteine in Several Pure and Binary Solvent Systems

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The mole fraction solubility data of N-acetyl-l-proline in 16 neat solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, n-pentanol, acetone, 2-butanone, acetonitrile, dichloromethane, methyl acetate, ethyl acetate, and 1,4-dioxane) covering a temperature range of 283.15–323.15 K were measured by the static gravimetric method. The polymorphism of N-acetyl-l-proline was investigated by the powder X-ray diffraction test and the patterns show that there are two polymorphs within the studied solid–liquid equilibrium systems. The increasing temperature shows a positive effect on N-acetyl-l-proline solubility in all of the solvents and the largest increasing rate is observed in acetonitrile with an increase of 16-fold. The solubility behavior was found to be influenced by five factors including polarity, hydrogen bonding, solvent–solvent interactions, molecular construction, and viscosity. Two thermodynamic models, i.e., the modified Apelblat model and the Yaws model, were used for the correlation of solubility data. To evaluate the fitting results, the average relative deviation (ARD) and root-mean-square deviation (RMSD), as well as the Akaike information criterion (AIC) and Akaike weights, were computed for each model.

Section: Experimental Sectionsupporting

confidence: 61%

Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K

Huang

Qiu

et al. 2021

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“…All chemicals were used in the experiments as received without further processing. The solubility data of l -arginine l -pyroglutamate in different solvent systems were determined by the static gravimetric method, which has been described and verified in our previous studies. − The method mainly includes three steps: solid–liquid equilibrium, solid–liquid phase separation, and supernatant analysis. The detailed process for solubility determination is given in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Solubility Behavior and Polymorphism of l-Arginine l-Pyroglutamate in Nine Pure Solvents and a Binary Water + Ethanol System

Han

Liu

et al. 2021

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The solubility data of L-arginine L-pyroglutamate were determined by the static gravimetric method from 283.15 to 323.15 K in nine pure solvents (water, methanol, ethanol, isopropanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and n-hexane) and a water + ethanol binary solvent system. According to experimental results, solubility was positively correlated with temperature. In the selected solvent systems, three different polymorphs denoted as α-form, β-form, and γ-form were found. In addition, from the data analysis results, the polarity, hydrogen bonding, Hildebrand solubility parameters, and the molecular structure affected the dissolution equilibrium. Two thermodynamic models including the modified Apelblat model and the Yaws model were used to correlate the solubility data. Meanwhile, these models were evaluated by the Akaike information criterion method.

“…These samples were scanned at a rate of 10°/min with scanning angles (2θ) ranging from 5 to 60°, and the working current and voltage were 150 mA and 40 kV respectively. The sample preparation process involved can be found in our previous studies. − The XRPD spectra are shown in Figure graphically.…”

Section: Experimental Sectionmentioning

confidence: 99%

Measurement and Correlation for Solubility of Myo-inositol in Five Pure and Four Binary Solvent Systems

Guo

Huang

et al. 2021

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The equilibrium solubilities of myo-inositol in five monosolvents (water, methanol, ethanol, isopropanol, acetone) and four binary solvent systems (water + methanol, water + ethanol, water + isopropanol, water + acetone) were determined using the static gravimetric method from 283.15 to 323.15 K under the ambient pressure of 98.8 kPa. The KAT-LSER model was used to perform the multiple linear regression analysis on mixed solvent systems to reveal the solvent effect on solubility. The Hansen solubility parameter was employed to reveal the solubility behavior of myo-inositol. Three thermodynamic models, including the modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models, were employed for fitting the solubility data.