Determination and modeling of the solubility of (limonin in methanol or acetone+water) binary solvent mixtures at T=283.2K to 318.2K

Fan, Jie; Zheng, Bing; Liao, Dongmei; Yu, Jiaxin; Cao, Yijun; Zhang, Xuehong; Zhu, Jianqing

doi:10.1016/j.jct.2016.03.037

Cited by 29 publications

(16 citation statements)

References 43 publications

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“…where B 0 , B 1 , B 2 , B 3 , and B 4 are the equation constants and regressed from solubility data by nonlinear least-squares method. 30,31 Apel−JA Equation. The Jouyban−Acree equation describes the effects of both solvent composition and temperature on solubility in binary mixed solvent systems, defined as follows:…”

Section: Resultsmentioning

confidence: 99%

“…The (CNIBS)/Redlich–Kister equation, proposed by Acree et al, expresses the correlation between the mole fraction solubility and solvent composition in binary solvent mixtures at a given temperature by where x 1 is the mole fraction solubility of INH; x 2 and x 3 are the solute-free mole fraction of alcohol and water, respectively, satisfying x 2 + x 3 = 1; X 2 and X 3 represent the saturated solubility of INH in corresponding pure solvents, and S i denotes the equation parameter . For a binary solvent mixture, N = 2, eq can be simplified as Equation can be further simplified as where B 0 , B 1 , B 2 , B 3 , and B 4 are the equation constants and regressed from solubility data by nonlinear least-squares method. , …”

Section: Resultsmentioning

confidence: 99%

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Solubility and Data Correlation of Isoniazid in Different Pure and Binary Mixed Solvent Systems from 283.15 K to 323.15 K

et al. 2018

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The solubility of isoniazid (INH) in eight pure solvents (water, methanol, ethanol, n-propanol, isopropyl alcohol, DMF, ethyl acetate, and acetonitrile) and three binary solvent mixtures of methanol–water, ethanol–water, and isopropyl alcohol–water were experimentally determined by gravimetric method at temperatures ranging from (283.15 to 323.15) K. Expectedly, the solubility displays temperature dependence, and the most remarkable change was found in water. In all three binary solvent mixtures, INH solubility bears a maximum at 0.2–0.4 mole fraction of alcohols, and the maximum solubility values were found varying with temperature. The experimental solubility data were well correlated by the modified Apelblat, van’t Hoff, CNIBS/R–K, and Apel–JA equations. Among these models, the modified Apelblat model produces the best fitting results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Solubility and Data Correlation of Isoniazid in Different Pure and Binary Mixed Solvent Systems from 283.15 K to 323.15 K

et al. 2018

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“…The solubility was measured according to our previous work . First, an excess solid solute (OA or UA) was added into a vial with about 15.0 mL solvent, which was stoppered and sealed up with tape to prevent the solvent from escaping.…”

Section: Methodsmentioning

confidence: 99%

“…The solubility was measured according to our previous work. 16 First, an excess solid solute (OA or UA) was added into a vial with about 15.0 mL solvent, which was stoppered and sealed up with tape to prevent the solvent from escaping. Second, the vial was placed in a low temperature thermostatic reaction bath (type DFY5/40, Gongyi Yuhua Instrument Co., Ltd., China) with an uncertainty of ±0.1 K. The solution in the vial was stirred by an electric magnetic stirrer for about 48 h to make sure of the achievement of equilibrium, and then stood for another 12 h to obtain a upper clear saturated solution.…”

Section: Introductionmentioning

confidence: 99%

Determination and Modeling of the Solubilities of Oleanolic Acid and Ursolic Acid in Ethanol + Sodium Hydroxide + Water Mixed Solvents from T = 283.2 to 323.2 K

et al. 2017

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The solubilities of oleanolic acid (OA) and ursolic acid (UA) in ethanol + sodium hydroxide + water mixed solvents were measured at different temperatures (283.2, 298.2, 293.2, 298.2, 303.2, 308.2, 313.2, 318.2, and 323.2 K). The solubility of OA in the mixed solvents increased with temperature. However, the solubility of UA in the mixed solvents first increased with temperature, and then decreased with temperature. The solubilities of both OA and UA increased with the initial mole fraction of ethanol in the mixed solvents. The addition of NaOH could improve the solubilities of OA and UA in the aqueous ethanol solution. The solubility of OA was correlated with temperature by the van’t Hoff model, the modified Apelblat model and the λh model, and the results indicated that the λh model had better correlation. The solubility of UA was correlated with temperature only by an empirical cubic equation.

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“…The solubility of limonin was reported only in some aqueous media 11 and several organic solvents and buffer solutions at 310.15 K. 12 In our previous work we also have reported the solubility of limonin in acetone + water mixtures at various temperatures. 13 However, the solubility of limonin at various temperatures in the eight organic solvents (listed in Table 1) and ethyl acetate + 2propanol mixtures has not been systematically studied. These solvents are common and widely used to dissolve and separate chemicals in pharmaceutical and chemical industry.…”

Section: Introductionmentioning

confidence: 99%

Determination and Thermodynamic Analysis of the Solubility of Limonin in Eight Organic Solvents and Ethyl Acetate + 2-Propanol Binary Solvents from 283.2 to 323.2 K

Fan

Yuan

et al. 2018

J. Chem. Eng. Data

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In the present study, the solubility of limonin in eight organic solvents and a binary solvent system (ethyl acetate + 2-propanol) was determined by the high-performance liquid chromatography analysis method within the temperature range from 283.2 to 323.2 K. The results showed that the solubility of limonin increased with temperature in the eight pure solvents and the binary solvent mixtures. In the binary solvent system ethyl acetate + 2-propanol, the solubility decreased with the initial mole fraction of ethyl acetate. The experimental solubility of limonin was well correlated with temperature by the simplified thermodynamic equation, modified Apelblat equation, λh equation, and NRTL equation. Furthermore, the solubility of limonin in the binary solvent mixtures was correlated with both temperature and initial solvent composition of the binary solvent mixtures by the Jouyban−Acree model, van't Hoff−Jouyban−Acree model, modified Apelblat−Jouyban−Acree model, Ma model, Sun model, and NRTL model. Finally, the thermodynamic properties of the mixing process, including mixing Gibbs energy, mixing enthalpy, and mixing entropy, were also calculated.

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Determination and modeling of the solubility of (limonin in methanol or acetone+water) binary solvent mixtures at T=283.2K to 318.2K

Cited by 29 publications

References 43 publications

Solubility and Data Correlation of Isoniazid in Different Pure and Binary Mixed Solvent Systems from 283.15 K to 323.15 K

Solubility and Data Correlation of Isoniazid in Different Pure and Binary Mixed Solvent Systems from 283.15 K to 323.15 K

Determination and Modeling of the Solubilities of Oleanolic Acid and Ursolic Acid in Ethanol + Sodium Hydroxide + Water Mixed Solvents from T = 283.2 to 323.2 K

Determination and Thermodynamic Analysis of the Solubility of Limonin in Eight Organic Solvents and Ethyl Acetate + 2-Propanol Binary Solvents from 283.2 to 323.2 K

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