Determination and Simulation of the Solubility of Bifonazole in 14 Pure Solvents at 283.15–323.15 K

Abstract

Bifonazole is a derivative of imidazoles with a wide antibacterial spectrum and is widely used for treating various fungi infections. However, in the open literature, the solubility data of bifonazole are rarely reported. Considering the importance of the solubility of bifonazole in its manufacture and applications, the solubility of bifonazole in 8 alcohols and 4 n-alkyl acetates as well as acetonitrile and N, N-dimethylformamide in the temperatures ranging from 283.15 to 323.15 K has been measured with the assistance of a dynamic laser solubility monitoring device in this paper. The measured solubility of bifonazole follows the order of DMF > alcohols > esters > acetonitrile. The relationship between the solubility of bifonazole and temperature was correlated using three semi-empirical and two activity coefficient solubility models. In addition, the thermodynamic mixing properties (Δmix G, Δmix H, Δmix S, γ1 ∞, and H 1 E, ∞) of the bifonazole solutions were evaluated in terms of experimental data and Wilson model parameters.

Measurements and Correlation of Timolol Maleate Solubility in Biobased Neat and Binary Solvent Mixtures

“…The semiempirical Yaws equation (eq ), first proposed by Yaws to correlate the solubility of hydrocarbons in water, has been widely applied to correlate the solubility of various solutes in monosolvents − and binary solvent mixtures ln nobreak0em0.25em⁡ x 1 = A 2 + B 2 T + C 2 T 2 …”