In this paper, the solubility of clotrimazole, an antifungal drug, in 10 alcohols (n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, n-pentanol, iso-pentanol, n-hexanol, n-heptanol, and n-octanol) and 6 esters (methyl acetate, ethyl acetate, npropyl acetate, n-butyl acetate, isopropyl acetate, and methyl propionate) was experimentally determined using a laser dynamic solubility-monitoring device in a temperature range of 283.15 to 323.15 K at atmospheric pressure. The functions of solubility versus temperature were regressed using three semi-empirical models (modified Apelblat, three-parameter van't Hoff, and λh) and two activity coefficient models (Wilson and NRTL). The results show that all the five models can be used to correlate the solubility of clotrimazole with temperature in these solvents satisfactorily. Furthermore, the thermodynamic mixing properties (Δ mix G, Δ mix H, Δ mix S, ln(γ 1 ∞ ), and H 1 E, ∞ ) were evaluated using the measured solubility values and Wilson model parameters.

In this paper, the solubility of artesunate, a drug for the treatment of malaria, was determined by a laser dynamic method in 13 pure solvents (including seven alcohols and six esters) in the temperature range from 283.15 to 323.15 K under a pressure of 101.3 KPa. The solubility of artesunate in the 13 pure solvents increases with increasing temperature and follows the order: ethanol > amyl alcohol > propanol > methyl propionate > ethyl acetate > butanol > isopropanol > isobutanol ≈ isoamyl alcohol > propyl acetate > butyl acetate > isopropyl acetate > amyl acetate. Three semi-empirical models (modified Apelblat, three-parameter Van’t Hoff, and λh model) and two activity coefficient models (Wilson and NRTL) have been used to correlate the experimental data. Moreover, the mixing thermodynamic properties (Δmix G, Δmix S, and Δmix H) of solutions have been estimated using the solubility data and the regressed Wilson model parameters.

In this paper, the solubility of terbinafine hydrochloride in 13 mono-solvents was measured in the temperature range from 283.15 K to 323.15 K at ambient pressure with the assistance of a laser-based dynamic solubility-monitoring device. It was concluded that the solubility of terbinafine hydrochloride in these mono-solvents increases with rising temperature. At 323.15 K, the molar solubility shows the following order: cyclohexanol (7.739 × 10 −2 ) > n-propyl alcohol (7.351 × 10 −2 ) > n-amyl alcohol (6.967 × 10 −2 ) > iso-butanol (6.932 × 10 −2 ) > n-butanol (6.850 × 10 −2 ) ≈ ethanol (6.778 × 10 −2 ) > isoamyl alcohol (4.926 × 10 −2 ) >1hexanol (4.689 × 10 −2 ) > dimethyl sulfoxide (4.010 × 10 −2 ) > sec-butanol (2.878 × 10 −2 ) > isopropyl alcohol (2.452 × 10 −2 ) > isooctyl alcohol (2.211 × 10 −2 ) > acetonitrile (0.532 × 10 −2 ). Subsequently, the relationship between the solubility of terbinafine hydrochloride and temperature was correlated by six models (Apelblat, van't Hoff, λh, Wilson, NRTL, and Jouyban models), and the mixing thermodynamic properties of the solutions were evaluated with the solubility and the parameters simulated by the Wilson model. In addition, the solvent effect on the solubility of terbinafine hydrochloride was discussed based on the Kamlet−Abboud− Taft linear solvation energy relationships.

Bifonazole is a derivative of imidazoles with a wide antibacterial spectrum and is widely used for treating various fungi infections. However, in the open literature, the solubility data of bifonazole are rarely reported. Considering the importance of the solubility of bifonazole in its manufacture and applications, the solubility of bifonazole in 8 alcohols and 4 n-alkyl acetates as well as acetonitrile and N, N-dimethylformamide in the temperatures ranging from 283.15 to 323.15 K has been measured with the assistance of a dynamic laser solubility monitoring device in this paper. The measured solubility of bifonazole follows the order of DMF > alcohols > esters > acetonitrile. The relationship between the solubility of bifonazole and temperature was correlated using three semi-empirical and two activity coefficient solubility models. In addition, the thermodynamic mixing properties (Δmix G, Δmix H, Δmix S, γ1 ∞, and H 1 E, ∞) of the bifonazole solutions were evaluated in terms of experimental data and Wilson model parameters.