Determination and Modeling of Artesunate Solubility in 13 Pure Solvents at 283.15–323.15 K

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In this paper, the solubility of terbinafine hydrochloride in 13 mono-solvents was measured in the temperature range from 283.15 K to 323.15 K at ambient pressure with the assistance of a laser-based dynamic solubility-monitoring device. It was concluded that the solubility of terbinafine hydrochloride in these mono-solvents increases with rising temperature. At 323.15 K, the molar solubility shows the following order: cyclohexanol (7.739 × 10 −2 ) > n-propyl alcohol (7.351 × 10 −2 ) > n-amyl alcohol (6.967 × 10 −2 ) > iso-butanol (6.932 × 10 −2 ) > n-butanol (6.850 × 10 −2 ) ≈ ethanol (6.778 × 10 −2 ) > isoamyl alcohol (4.926 × 10 −2 ) >1hexanol (4.689 × 10 −2 ) > dimethyl sulfoxide (4.010 × 10 −2 ) > sec-butanol (2.878 × 10 −2 ) > isopropyl alcohol (2.452 × 10 −2 ) > isooctyl alcohol (2.211 × 10 −2 ) > acetonitrile (0.532 × 10 −2 ). Subsequently, the relationship between the solubility of terbinafine hydrochloride and temperature was correlated by six models (Apelblat, van't Hoff, λh, Wilson, NRTL, and Jouyban models), and the mixing thermodynamic properties of the solutions were evaluated with the solubility and the parameters simulated by the Wilson model. In addition, the solvent effect on the solubility of terbinafine hydrochloride was discussed based on the Kamlet−Abboud− Taft linear solvation energy relationships.

Section: Resultssupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Powder X-ray Diffraction Analysismentioning

confidence: 99%

Section: Powder X-ray Diffraction Analysismentioning

confidence: 99%

Section: Powder X-ray Diffraction Analysismentioning

confidence: 99%

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Solubility Determination and Thermodynamic Correlation for Terbinafine Hydrochloride in Several Mono-solvents from 283.15 to 323.15 K

Yang

Wang

et al. 2023

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Determination and Simulation of the Solubility of Bifonazole in 14 Pure Solvents at 283.15–323.15 K

Wang

Yang

et al. 2023

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Bifonazole is a derivative of imidazoles with a wide antibacterial spectrum and is widely used for treating various fungi infections. However, in the open literature, the solubility data of bifonazole are rarely reported. Considering the importance of the solubility of bifonazole in its manufacture and applications, the solubility of bifonazole in 8 alcohols and 4 n-alkyl acetates as well as acetonitrile and N, N-dimethylformamide in the temperatures ranging from 283.15 to 323.15 K has been measured with the assistance of a dynamic laser solubility monitoring device in this paper. The measured solubility of bifonazole follows the order of DMF > alcohols > esters > acetonitrile. The relationship between the solubility of bifonazole and temperature was correlated using three semi-empirical and two activity coefficient solubility models. In addition, the thermodynamic mixing properties (Δmix G, Δmix H, Δmix S, γ1 ∞, and H 1 E, ∞) of the bifonazole solutions were evaluated in terms of experimental data and Wilson model parameters.

Determination and Thermodynamic Model of the Solubility of Levodropropizine in 13 Pure Solvents at 283.15–323.15 K

Dong,

Wang,

et al. 2023

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In this paper, the solubility of levodropropizine, an important cough suppressant drug, in 13 pure solvents (including 8 alcohol solvents and 5 acetate solvents) was studied with the aid of a laser dynamic solubility-monitor device at a temperature from 283.15 to 323.15 K and atmosphere pressure. In the measured temperature range, the solubility of LVDP increases with increasing temperature and follows the following order: iso-butanol > iso-pentanol > n-hexanol ≈ n-heptanol > n-pentanol > npropanol > n-butanol > iso-propanol > ethyl acetate > n-propyl acetate > n-butyl acetate > n-pentyl acetate > iso-propyl acetate. Three semiempirical models (modified Apelblat, three-parameter van't-Hoff, and λh) and two activity coefficient models (Wilson and NRTL) were used to correlate solubility of LVDP as a function of temperature and the mixing thermodynamic properties of the 13 solutions were evaluated based on measured solubility and the parameter values of Wilson's model.