Determination of 5-Hydroxyindole Acetic Acid by Electrochemical Methods with an Oxidized Glassy Carbon Electrode

Liu, Shuangyan; Chen, Yongmei; Wan, Pingyu; Zhou, Chen; Zhang, Sheng; Mo, Hengliang

doi:10.1016/j.electacta.2016.09.001

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…The results indicate that the redox behavior of the CBL derivative on e-GCE CP−CV is an adsorption-controlled process. 39 It is a further verified previous deduction that 1-naphthol was transformed to 1,4-naphthoquinone during regulation III, so as to adsorb on the surface of the electrode before electroreduction from −0.1 to −0.25 V. In addition, the DPV curves and calibration plot of reduction potential against varying pH values in Figure 6c,d Therefore, the slope of 0.057 V/pH is close to the theoretical value of 0.0592 V/pH, suggesting that the number of protons involved is equal to electrons, so the electrochemical process of the CBL derivative on e-GCE CP−CV is a 2H + /2e − Nernstian response. As demonstrated above, the whole reaction from CBL to 1,4-naphthylenediol is shown as Scheme 2.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl

Zhang

Yang

et al. 2023

Anal. Chem.

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Specific and sensitive sensing of most pesticide residues relies on enzymes such as acetylcholinesterase and advanced materials, which need to be loaded on the surface of working electrodes, leading to instability, uneven surface, tedious process, and high cost. Meanwhile, employing certain potential or current in electrolyte solution could also modify the surface in situ and overcome these drawbacks. However, this method is only regarded as electrochemical activation widely applied in the pretreatment of electrodes. In this paper, by means of regulating the electrochemical technique and its parameters, we prepared a proper sensing interface and derivatized the carbaryl (a carbamate pesticide) hydrolyzed form (1-naphthol) to enhance sensing by 100 times within several minutes. After regulation I by chronopotentiometry with 0.2 mA for 20 s or chronoamperometry with 2 V for 10 s, abundant oxygen-containing groups form and the ordered carbon structure is destroyed. Sweeping from −0.5 to 0.9 V through cyclic voltammetry for only one segment, following regulation II, the composition of oxygen-containing groups changes and the disordered structure is alleviated. Finally, on the constructed sensing interface, test by regulation III through differential pulse voltammetry from 0.8 to −0.4 V, resulting in derivatization of 1-naphthol during 0.8–0 V, followed by electroreduction of the derivative at around −0.17 V. Compared with the electro-oxidation peak at 0.5 V in previous reports, it is essential to improve specificity, even toward several other carbamate pesticides with similar structures. Hence, the in situ electrochemical regulation strategy has demonstrated great potential for effective sensing of electroactive molecules.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl

Zhang

Yang

et al. 2023

Anal. Chem.

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“…(Table S3). The concentrations in healthy people are 0.5–1.4 μM for 5-HT in the blood plasma and 16–94 μM for 5-HIAA in the urine, while the critical values for carcinoid tumor patients are about 1.9 and 126 μM for 5-HT and 5-HIAA, respectively. , Because of the lower LODs than the danger values for carcinoid tumor patients, Zn-MOF 1 can quantitatively indicate the level of 5-HT and 5-HIAA.…”

Section: Resultsmentioning

confidence: 99%

Tetraphenylpyrazine-Based Luminescent Metal–Organic Framework for Chemical Sensing of Carcinoids Biomarkers

Ying

Chen

et al. 2021

ACS Appl. Mater. Interfaces

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A new non-interpenetrated three-dimensional (3D) pillared-layered TPP-based LMOF [Zn3(TPyTPP)0.5(BDC)3]·8DMF (denoted as Zn-MOF 1) was successfully prepared (TPyTPP = tetrakis(4-(pyridin-4-yl)phenyl)pyrazine and H2BDC = 1,4-benzenedicarboxylic acid). Zn-MOF 1 was characterized by single-crystal X-ray diffraction, PXRD, IR, N2 adsorption, thermogravimetric analysis, and luminescent spectrum. Impressively, luminescent sensing studies reveal that activated Zn-MOF 1 not only displays excellent luminescence-quenching efficiency with the values of high K sv and low LODs toward 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, but also possesses outstanding sensing characteristics in terms of fast response, high sensitivity, and specific selectivity. Zn-MOF 1 performs as efficient sensing of carcinoid biomarkers to provide a fresh detection platform for the diagnosis of carcinoids. In addition, the sensing mechanism was also explored on the basis of ultraviolet–visible (UV–vis) absorption, DFT calculations, and structural analysis.

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“…[ 1–4 ] Generally, the clinically relevant concentration variations of most disease markers in biological samples are very small, which spans even less than an order of magnitude between healthy people and patients. [ 5–7 ] For example, vanillylmandelic acid (VMA), which serves as a clinical indicator for pheochromocytoma (PHEO, a neuroendocrine tumor arising from the chromaffin cells of the adrenal medulla), is produced as 1.0–2.9 × 10 −5 mol L −1 by normal physiological process in healthy people, and only has a threefold increase during the pathological process of PHEO. [ 8,9 ] Such tiny concentration changes are very hard to be precisely distinguished and easy to bring in false‐positive/negative diagnostic results.…”

Section: Methodsmentioning

confidence: 99%

Structure Engineering of a Lanthanide‐Based Metal–Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

Hao

Niu

et al. 2020

Advanced Materials

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Exploring innovative technologies to precisely quantify biomolecules is crucial but remains a great challenge for disease diagnosis. Unfortunately, the humoral concentrations of most biotargets generally vary within rather limited scopes between normal and pathological states, while most literature‐reported biosensors can detect large spans of targets concentrations, but are less sensitive to small concentration changes, which consequently make them mostly unsatisfactory or even unreliable in distinguishing positives from negatives. Herein, a novel strategy of precisely quantifying the small concentration changes of a certain biotarget by editing the dynamic ranges and sensitivities of a lanthanide‐based metal–organic framework (Eu‐ZnMOF) biosensor is reported. By elaborately tailoring the biosensor's structure and surface areas, the tunable Eu‐ZnMOF is developed with remarkably enhanced response slope within the “optimized useful detection window,” enabling it to serve as a powerful signal amplifier (87.2‐fold increase) for discriminating the small concentration variation of urinary vanillylmandelic acid (an early pathological signature of pheochromocytoma) within only three times between healthy and diseased subjects. This study provides a facile approach to edit the biosensors' performances through structure engineering, and exhibits promising perspectives for future clinical application in the non‐invasive and accurate diagnosis of severe diseases.

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Determination of 5-Hydroxyindole Acetic Acid by Electrochemical Methods with an Oxidized Glassy Carbon Electrode

Cited by 16 publications

References 29 publications

Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl

Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl

Tetraphenylpyrazine-Based Luminescent Metal–Organic Framework for Chemical Sensing of Carcinoids Biomarkers

Structure Engineering of a Lanthanide‐Based Metal–Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

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