Determination of 8:2 fluorotelomer alcohol in animal plasma and tissues by gas chromatography–mass spectrometry

Biotransformation of 8:2 fluorotelomer alcohol by recombinant human cytochrome P450s, human liver microsomes and human liver cytosol

“…All samples were monitored in the electron impact (EI) ionization mode. 38 Compound separation and quantication were performed on an HP-5MS column (30 m  0.25 mm i.d., 0.25 mm lm thickness, Agilent Company) using helium as the carrier gas. Samples (2 mL) were introduced into the capillary inlet (injector temperature 225 C).…”

Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic–pituitary–gonadal (HPG) axis of zebrafish

“…The synthetic process of FTOHs usually produces a mixture with different carbon chain length FTOHs, such as 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluoro-decan-1-ol (8:2 FTOH) (Szostek and Prickett, 2004). FTOHs are known as volatile chemicals that are capable of long-range atmospheric transport and have been shown in atmosphere (Jahnke et al, 2007;Shoeib et al, 2006;Stock et al, 2004).…”

Application of Gas Chromatography to Determination of Total Organic Fluorine after Defluorination of Perfluorooctanoic Acid as a Model Compound

“…Without derivatization the GC was employed with chemical ionization in the determination of perfluorooctane sulfonate (PFOS) precursors and fluorotelomer alcohols, 17 while with electron impact ionization in the determination of 8:2 telomer alcohol in animal plasma and tissues. 18 Then with an appropriate derivatization and chemical ionization the GC/MS was used in the determination of PFCAs in aqueous matrices, 19 and sediments, 20 and also in isolating isomers of perfluorocarboxylates in polar bears. 21 Recently in our research group we have developed a HPLC method as mentioned above for the determination of TOF, based on the transformation of fluoride into TPSiF.…”