Determination of a new oral cephalosporin, S-1090, in human plasma and urine by direct injection high-performance liquid chromatography with ultraviolet detection and column switching

Fujitomo, H; Nagaoka, Tadayoshi; Nishino, Ikuko; Umeda, Tsuneji

doi:10.1016/s0378-4347(99)00093-6

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…S-1090 presents peak plasma levels higher than those of cefdinir. After 100 mg dose, C max was 2.52 µg/ml in fasting subjects and 2.93 µg/ml in non-fasting volunteers [41]. In another study, single oral doses of 50, 75, 100 and 200 mg were administered to healthy human volunteers after a meal.…”

Section: Pharmacokineticsmentioning

confidence: 98%

Novel oral cephalosporins

Cazzola

2000

Expert Opinion on Investigational Drugs

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The therapeutic use of oral cephalosporins to treat infectious diseases continues to challenge clinicians; many attempts have been made over recent years to improve the efficacy and spectrum of these anti-infectives. Many oral cephalosporins are in development and include cefdinir, cefprozil, cefetamet pivoxil, cefcapene pivoxil, cefcanel daloxate hydrochloride in Phase II trials, S-1090 in Phase III trials and the novel compounds E1100, E1101 and BRL-57347. Differences between these drugs are sometimes subtle and the improvement over existing compounds modest, although recent cephalosporins have shown greater activity against Gram-negative bacterial infections. A better knowledge of the pharmacodynamic and pharmacokinetic interrelationships of existing oral cephalosporins is demanded for a more rational use of these compounds and to avoid the subsequent development of resistance. Perhaps with such an approach, the perceived need for new cephalosporins will diminish.

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Section: Pharmacokineticsmentioning

confidence: 98%

Novel oral cephalosporins

Cazzola

2000

Expert Opinion on Investigational Drugs

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“…The concentration of the CPC residues in the compost was analyzed according to the following procedure [17,18]: 2 g of fresh sample was extracted by using a mixture of 15 ml acetonitrile, 10 ml acetonitrile saturated n-hexane and 5 g anhydrous sodium sulfate. After vortexing for 3 min and ultrasonic treatment for 15 min, the mixture was centrifuged at 6000 rpm for 5 min.…”

Section: Measurement Of Cpcmentioning

confidence: 99%

Feasibility study of recycling cephalosporin C fermentation dregs using co-composting process with activated sludge as co-substrate

Chen

Wang

Wen

et al. 2016

Environmental Technology

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Composting is a potential alternative for cephalosporin C fermentation dregs (CCFDs) compared with incineration process or landfill because of its advantage of recovering nutrients. In this research, CCFDs and activated sludge (AS) were co-composted to analyze the feasibility of recycling the nutrients in CCFDs. A pilot-scale aerobic composting system with an auto-control system was used in this research, and the maturity and security of the compost product were evaluated. The temperature of the composting mixtures was maintained above 55°C for more than 3 days during the composting, indicating that co-composting of CCFDs and AS could reach the compost maturity standard, and the seeds germination index (GI) increased from 17.61% to 68.93% by the end of the composting process (28 days). However, the degradation rate of cephalosporin C (CPC) was only 6.58% during the composting process. Monitoring the quality of antibiotic resistance genes (ARGs) in the composts showed that the log copy of blaTEM in the composts increased from 2.15 in the initial phase to 6.37 after 28 days. Long-term investigation of CPC degradation and ARGs variation was conducted for the composts; CPC could still be detected after the maturity phases. A removal efficiency of 49.10% could be achieved in 110 days, while the log copy of ARGs increased to 7.93. Although a higher GI value (>80.00%) was observed, the risk of recycling the CCFDs compost product into land is still high.

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“…An internal-surface reversed-phase precolumn was applied for plasma assay, while two precolumn packed with cyano and phenyl bonded silica were effective for urine samples. 8 The analyte fraction transferred from the precolumn was finally separated on an octadecyl analytical column. Three precolumns with different bonded silica, connected in the order C 8 , silica-CN and silica-phenyl were included in a fully automated HPLC system for hydroxybenzeno[a]pyrene determination.…”

Section: On-line Coupling Of Spe With Hplcmentioning

confidence: 99%

“…Immunosorbents and molecular imprinted materials, which are based on molecular recognition, also allow achieving isolation and preconcentration in a single step. On-line SPE sample processing is very well suited for analysis of biological fluids such as urine [7][8][9][10]15,[20][21][22][23][25][26][27]30,31,37,39,[44][45][46]59,[94][95][96][97][98][99]102 and plasma. 7,8,15,16,18,20,22,33,36,37,56,57,69,[70][71][72][73]94,96,100 The determination of various pharmaceutics and drugs of this kind of matrices is required for pharmacokinetic and bioavailability studies 7,8,15,16, 30,38, 45,56, …”

Section: Application To Real Samplesmentioning

confidence: 99%