Determination of Adhesion and Colonisation Intensity of Staphylococcus epidermidis and Pseudomonas aeruginosa on the Surface of Originally Synthesised Biomaterials in vitro and in vivo Studies, and Their Impact on Inflammatory Cytokine Expression in Tissues. Summary of the Doctoral Thesis

Abstract

Abbreviations………………………………………………………………………… INTRODUCTION…………………………………………………………………… 1. MATERIAL AND METODS……………………………………………………... 1.1. Biomaterials used in study………………………………………………. 1.2. Microorganims used in the study………………………………………... 1.3. Determining microorganism adhesion in vitro………………………….. 1.4. Determining microorganism colonisation in vitro………………………. 1.5. Determining microorganism colonisation in vivo……………………….. 1.6. Inflammatory cytokine expression determination in vivo……………….. 1.7. Statistics methods……………………………………………………….. 2. RESULTS……………………………………………………………………….…. 2.1. Glass ceramic biomaterialsin vitro and in vivo examination…………. 2.1.1. Bacterial adhesion in vitro on glass ceremic biomaterials…..... 14 2.1.2. Bacterial colonisation in vitro on glass ceramic biomaterials… 2.1.3. Glass ceramic biomaterial examination results with scanning electron microscope…………………………………………… 2.1.4. Glass ceramic biomaterial colonisation in vivo……………….. 2.1.5. Glass ceramic biomaterial immunohistochemical study findings………………………………………………………... 2.2. Examination of bacterial adhesion and colonisation on Titanium Dioxide and Hydroxyapatite composite materials………………………. 2.3. Intensity of bacterial adhesion and colonisation in vitro on the surface of synthetic calcium phosphate biomaterials…………………………….. 2.4. Intensity of bacterial adhesion and colonisation in vitro on the surface of hydroxyapatites and silver containing biomaterials…………………...