Determination of adropin, body mass index and other biochemical parameters in Iraqi type II diabetic patients

Abstract

Evidence suggests a hormone peptide named adropin, is involved in lipid metabolism, insulin resistance, and obesity. However, its role in pathogenesis of type 2 diabetes mellitus (T2DM) is still unclear in humans. Therefore, we investigated whether adropin levels are altered in T2DM patients, and evaluated its association with diabetes- related parameters. Samples which collected from 180 subjects were divided into case group [n = 90] and control groups [n = 90]. The mean age was [43.17 ±11.13] years. Men (n=81) and femanl (n=99) were participated in case-control study. Serum adropin levels were determined by ELISA. The mean serum adropin level was significantly higher [P<0.01] in the control group compared to case group [6.9±1.3 vs. 5.8±1.2] respectively. The result shown there was a significant difference [P-value<0.001] between body mass index and adropin. adropin with high significant negative correlation [P-value<0.001] between adropin and body mass index, fasting blood sugar, glycated hemoglobin, insulin, and homeostatic model assessment for insulin resistance also a significant negative correlation was found between the adropin and low-density lipoprotein, triglyceride, very low-density lipoprotein and no significant with cholesterol, high-density lipoprotein.

The Association between Serum Adropin Level and Metabolic Complications of Type 2 Diabetes Mellitus

“…These results corroborated our observation that there is an inverse correlation between serum adropin levels and body mass index. The results were replicated in both in vivo and in vitro investigations (20)(21)(22)(23) .…”

Impact of diabetes mellitus on serum irisin level and other biochemical parameters

“…Although T2DM can occur at any age, it is the most common form of diabetes and often develops in adulthood. People who have T2DM exhibit resistance to the effects of the hormone insulin, which the pancreas normally secretes to regulate blood sugar levels (1). Due to this resistance, the cells of the body do not respond to insulin as well as they should, preventing glucose from entering the cells where it may be used as energy (2).…”

“…Due to this resistance, the cells of the body do not respond to insulin as well as they should, preventing glucose from entering the cells where it may be used as energy (2). As a result, there is an accumulation of glucose in the bloodstream, which raises blood sugar levels (1). Since T2DM is a metabolic condition that affects more than 400 million individuals globally, it is regarded as a complicated and multifaceted disease (3).…”