Determination of Airborne Polycyclic Aromatic Hydrocarbons by HPLC Using SPE-Type Collection Device

Ueta, Ikuo; Sekiguchi, Naho; Fujimura, Kazuma; Yoshimura, Tomotaka; Narukami, Shoji; Mochizuki, Suguru; Sasaki, Tomohiro; Kuwabara, Tetsuo; Maeda, Tsuneaki

doi:10.15583/jpchrom.2018.013

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…Our research group has developed a solid-phase extraction (SPE)-type collection device for the extraction of gaseous semi-volatile organic compounds, such as polycyclic aromatic hydrocarbons [17][18][19] and phthalate esters 20,21 in air samples. The SPE-type collection device was prepared by packing a styrene-divinylbenzene polymer particle of Sunpak-H into a glass cartridge.…”

Section: Analytical Sciencesmentioning

confidence: 99%

Extraction of Volatile Anticancer Drugs in Air Using a Solid-Phase Extraction Type Device Followed by Gas Chromatography–Mass Spectrometric Analysis

et al. 2020

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Ifosfamide (IF), cyclophosphamide (CP), and bendamustine (BD) are widely used anticancer drugs. These drugs have slight volatility; therefore, medical staff exposure is of concern in the medical field.However, accurate and quantitative detection method of these volatile drugs in air has not been reported. In this study, we developed the quantitative extraction and detection method of these volatile anticancer drugs in air. For the extraction of analytes, a solid-phase extraction type collection device packed with styrene-divinylbenzene polymer particles was used. The extracted analytes were quantitatively eluted with 5 mL ethanol, and the solution was concentrated to 100 µL with nitrogen purging. The analytes were analyzed using gas chromatography-mass spectrometry (GC-MS). The limit of detection of the proposed method for IF and CP were 0.017 and 0.033 ng L -1 , respectively in air at air sampling volume of 300 L. IF and CP showed slight volatility, whereas BD was not detected in GC-MS due to its lower volatility. The spiked recoveries of IF and CP in the proposed method were within the range of 95.5 to 101%. Finally, the proposed method was applied to determine the exposure of IF and CP during the dispensing of CP within a hospital dispensary room. The investigated volatile anticancer drugs were not detected in real air samples, indicating that the protection measures employed are sufficient.

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Section: Analytical Sciencesmentioning

confidence: 99%

Extraction of Volatile Anticancer Drugs in Air Using a Solid-Phase Extraction Type Device Followed by Gas Chromatography–Mass Spectrometric Analysis

et al. 2020

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“…We previously developed a solid-phase extraction (SPE)-type extraction device for collecting of volatile organic compounds (VOCs) in air samples [5,6]. The extraction device comprises a glass cartridge containing a particulate extraction medium (polymer particle of styrene-divinylbenzene (Sty-DVB)), and the extracted VOCs were eluted by passing a small amount of organic solvent through them.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Volatility of Bendamustine Using Solid Phase Extraction-Type Extraction Device

et al. 2022

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Bendamustine (BD), a volatile anti-cancer drug in Japan, was quantitatively evaluated using solid phase extraction (SPE)-type extraction device designed for the adsorption of gaseous semi-volatile organic compounds. First, the stability of BD was tested in various conditions, including solvent, temperature, and contact with oxygen. Then, the BD standard solution was spiked on filter paper, and the SPE-type extraction device was connected to the filter downstream. The filter and extraction device were then used to collect clean air. The actual volatility of BD was determined in high-performance liquid chromatography. Even after 24 h of air sampling at 7 L/min (10,080 L), the results demonstrated that BD evaporation was not confirmed. Furthermore, BD evaporation was not confirmed in a 7,000 L air sampling volume of heated air at 50°C. The volatility properties of n-alkanes of C 26 H 54 , C 28 H 58 , and C 30 H 62 in these air sampling conditions were compared. The results show that BD is not volatile at room temperature.

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“…Also high performed liquid chromatographs (HPLC method) are widely applied in these investigations (e.g., [20][21][22]). However, it is often not cost effective to apply these methods routinely to large numbers of samples.…”

Section: Introductionmentioning

confidence: 99%

The Use of Synchronous Fluorescence Technique in Environmental Investigations of Polycyclic Aromatic Hydrocarbons in Airborne Particulate Matter from an Industrial Region in Poland

Matuszewska¹,

Czaja²

2021

Environmental Emissions

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The applicability of the fluorescence techniques to identify the polycyclic aromatic hydrocarbons (PAHs) in environmental samples is presented. The technique of synchronous fluorescence enabled the identification of the PAHs series containing 2-6 condensed rings in urban airborne particulate matter from Upper Silesia industrial region in Poland. The results obtained by synchronous and conventional fluorescence measurements have been confirmed by those from gas chromatography-mass spectrometry. As the air sample was taken in summer season, the main source of pollution by PAHs component seems to be transport-the exhaust gases from motor vehicles.

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Determination of Airborne Polycyclic Aromatic Hydrocarbons by HPLC Using SPE-Type Collection Device

Cited by 8 publications

References 13 publications

Extraction of Volatile Anticancer Drugs in Air Using a Solid-Phase Extraction Type Device Followed by Gas Chromatography–Mass Spectrometric Analysis

Extraction of Volatile Anticancer Drugs in Air Using a Solid-Phase Extraction Type Device Followed by Gas Chromatography–Mass Spectrometric Analysis

Evaluation of Volatility of Bendamustine Using Solid Phase Extraction-Type Extraction Device

The Use of Synchronous Fluorescence Technique in Environmental Investigations of Polycyclic Aromatic Hydrocarbons in Airborne Particulate Matter from an Industrial Region in Poland

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