Determination of aliphatic amines by gas and high-performance liquid chromatography

Analytical Aspects of Amino, Quaternary Ammonium, Nitro, Nitroso and Related Functional Groups

“…Determination of trimethylamine oxide by HPLC with a pulsed amperometric detector was problematic 136 .…”

Determination of aliphatic amines by high-performance liquid chromatography-amperometric detection after derivatization with naphthalene-2,3-dicarboxaldehyde

“…Multiple extraction and sample enrichment are required to achieve good analyte recoveries. In addition, aliphatic amines lack native sensitivity to common LC detectors such as UV, fluorescence and electrochemical [24,25].…”

A fast method for the quantification of methylamine in fermentation broths by gas chromatography

“…Analysis by liquid chromatography usually takes much longer than by gas chromatography and a derivatisation step is normally required for detection. Analysis by gas chromatography is quicker, but unless derivatised such amines can only be analysed when packed or thickly coated columns are used [8][9][10]. Derivatisation also reduces the tendency for peak tailing and memory effects that are otherwise often observed in the case of small amines due to the pronounced hydrophilicity and hydrogen-bounding tendency of these strongly basic substances [11,12].…”