Determination of aminoglycoside antibiotics: Current status and future trends

Glinka, Marta; Wojnowski, W.; Wasik, Andrzej

doi:10.1016/j.trac.2020.116034

Cited by 69 publications

(28 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aminoglycoside antibiotics (AGs) are a class of broad-spectrum antibiotics whose molecules are composed of an aminocyclitol and one or more amino sugar molecules (d-glucosamine, d-kanosamine) connected by glucoside bonds (Figure 1) [1,2]. They are characterized by high polarity and hydrophilicity (logP values in the range from −4 to −9), and are very soluble in water, slightly soluble in methanol, and insoluble in non-polar organic solvents [3].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Luan

Wang

et al. 2020

Antibiotics

View full text Add to dashboard Cite

Antibiotic abuse is becoming increasingly serious and the potential for harm to human health and the environment has aroused widespread social concern. Aminoglycoside antibiotics (AGs) are broad-spectrum antibiotics that have been widely used in clinical and animal medicine. Consequently, their residues are commonly found in animal-derived food items and the environment. A simple, rapid, and sensitive detection method for on-site screening and detection of AGs is urgently required. In recent years, with the development of molecular detection technology, nucleic acid aptamers have been successfully used as recognition molecules for the identification and detection of AGs in food and the environment. These aptamers have high affinities, selectivities, and specificities, are inexpensive, and can be produced with small batch-to-batch differences. This paper reviews the applications of aptamers for AG detection in colorimetric, fluorescent, chemiluminescent, surface plasmon resonance, and electrochemical sensors for the analysis in food and environmental samples. This study provides useful references for future research.

show abstract

Section: Introductionmentioning

confidence: 99%

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Luan

Wang

et al. 2020

Antibiotics

View full text Add to dashboard Cite

show abstract

“…The antimicrobial molecule and the mechanism of action can also play a role in the action of antimicrobials upon biofilms. Therefore, the penetration of amikacin in biofilms may be difficult since aminoglycosides are large polar molecules [63]. Our results also show the failure of amikacin and tetracycline to eradicate biofilms is completely independent of any staphylococci species or origin.…”

Section: Effect Of Antimicrobials On 24 H-old Biofilmsmentioning

confidence: 64%

Exploring the Biofilm Formation Capacity in S. pseudintermedius and Coagulase-Negative Staphylococci Species

et al. 2022

View full text Add to dashboard Cite

The ability of biofilm formation seems to play an important role in the virulence of staphylococci. However, studies reporting biofilm formation of coagulase-negative staphylococci isolated from animals are still very scarce. Thus, we aimed to evaluate the biofilm-forming capacity of CoNS and S. pseudintermedius isolated from several animal species and to investigate the effect of conventional antimicrobials on biofilm reduction. A total of 35 S. pseudintermedius and 192 CoNS were included. Biofilm formation was accessed by the microtiter plate assay and the biofilms were stained by crystal violet. Association between biofilm formation and staphylococci species and antimicrobial resistance was also performed. Biofilm susceptibility testing was performed with tetracycline and amikacin at the minimum inhibitory concentration (MIC) and 10 × MIC. The metabolic activity of the biofilm cells after antimicrobial treatment was accessed by the XTT assay. All isolates formed biofilm, with S. urealyticus producing the most biofilm biomass and S. pseudintermedius producing the least biomass. There was a positive association between biofilm formation and multidrug resistance as well as resistance to individual antimicrobials. Neither tetracycline nor amikacin were able to eradicate the biofilm, not even at the highest concentration used. This study provides new insights into biofilm formation and the effects of antimicrobials on CoNS species.

show abstract

“…Indeed, as noted by Reemtsma et al [8], this kind of very polar molecules requires specific analytical tools which do not currently exist and which need to be developed. Analysis of AGs are more frequent in food-related samples as reported by Glinka et al [9] such as meat [10][11][12], milk [12,13] or honey [14][15][16][17][18]. Maximum residues limits are defined by food regulations and analytical method performances are set to respect these values.…”

Section: Introductionmentioning

confidence: 99%

Aminoglycosides analysis optimization using ion pairing liquid chromatography coupled to tandem mass spectrometry and application on wastewater samples

Guironnet

Sanchez-Cid

Vogel

et al. 2021

Journal of Chromatography A

View full text Add to dashboard Cite

Determination of aminoglycoside antibiotics: Current status and future trends

Cited by 69 publications

References 89 publications

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Exploring the Biofilm Formation Capacity in S. pseudintermedius and Coagulase-Negative Staphylococci Species

Aminoglycosides analysis optimization using ion pairing liquid chromatography coupled to tandem mass spectrometry and application on wastewater samples

Contact Info

Product

Resources

About