Determination of amlodipine and atorvastatin mixture by different spectrophotometric methods with or without regression equations

Magdy, Ragaa; Hemdan, A.; Fares, Nermine V.; Farouk, Maha

doi:10.1016/j.saa.2018.11.014

Cited by 23 publications

(8 citation statements)

References 22 publications

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“…Treatment of cardiovascular disease typically involves the use of a combination of medications, each of which contributes a unique mechanism of action to the overall treatment plan to accomplish olmesartan medoxomil (OML, Figure 1). It is an antihypertensive drug that belongs to the angiotensin II receptor blocker class of drugs [1]. Vascular constriction and tightening are consequences of angiotensin II.…”

Section: Introductionmentioning

confidence: 99%

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

Batakoushy,

Nasr,

Soliman

et al. 2023

Luminescence

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The present research has established a quick and highly sensitive second‐derivative synchronous fluorometric technique for the simultaneous quantification of a binary mixture of olmesartan medoxomil and rosuvastatin calcium. Simultaneously, the suggested approach was used to detect the synchronous fluorescence intensity of the cited drugs at Δ λ = 80 nm in ethanol to determine the concentrations of olmesartan medoxomil and rosuvastatin calcium at 265 and 240 nm, respectively. Various experimental conditions were tested, and each variable was analyzed and optimized. The calibration graphs were shown to be linear within ranges of 0.1–2.0 and 0.5–6.0 μg ml−1 for each drug concentration, respectively. The newly developed Green Solvents Selecting Tool (GSST) was utilized to assess the solvent's sustainability. Furthermore, the proposed method was found to be environmentally friendly after being evaluated with three different tools [the Green Analytical Procedure Index (GAPI), the Analytical Greenness Metric (AGREE), and the Analytical Eco‐Scale with Eco‐score equal to 95]. The whiteness qualities were also studied using the Red–Green–Blue (RGB12) model, which was recently designed and showed a high score equal to 92.9. The proposed method’s good findings, as well as its ongoing sustainability, simplicity, and economy, stimulate its application in QC laboratories.

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Section: Introductionmentioning

confidence: 99%

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

Batakoushy,

Nasr,

Soliman

et al. 2023

Luminescence

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“…The aim of the study is to apply different approaches to determine the drug studied in its zeroorder absorption spectrum without interference from one another. All developed methods (Constant center resolution technique (CC) [22], Constant center coupled with spectrum subtraction resolution technique (CC-SS) [22], and Advanced concentration value (ACV) [23][24][25][26][27] were applied for the determination of the cited drugs in pharmaceutical formulation and the results obtained were compared statistically with each other and with those of reported method.…”

Section: Introductionmentioning

confidence: 99%

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

et al. 2022

Self Cite

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Speciﬁc, and precise spectrophotometric methods are developed and validated for the simultaneous determination of the binary antihypertensive mixture nebivolol hydrochloride and valsartan in the zero-order spectrum. The methods applied for the determination of this antihypertensive mixture are constant center spectrophotometric resolution technique, constant center spectrum subtraction resolution technique, and advanced concentration value. Nebivolol hydrochloride was determined by its zero order spectra at 280 and 213 nm while for valsartan it determined by its zero order spectra at 250 nm. All developed methods were applied for the determination of the cited drugs in the pharmaceutical formulation and the results obtained were statistically compared with each other and with those of the reported method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

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“…Amlodipine besylate (AB) is a slow channel blocker (also known as dihydropyridine calcium antagonist), which inhibits the transmembrane entry of calcium ions into vascular smooth muscle and myocardium [1,2]. AB was mainly used clinically to treat hypertension and angina pectoris [3]. It has the functions of enhancing blood flow, lowering blood pressure, long-acting time, slow-onset [4,5].…”

Section: Introductionmentioning

confidence: 99%

A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC₄Pc Coated ZnO Composite Materials

Shao

2022

Electroanalysis

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In this study, tetracarboxylic manganese phthalocyanine coated nano-zinc oxide (MnC 4 Pc-ZnO) composite material was prepared by in-situ growth method and modified with indium tin oxide (ITO) glass electrode to construct a photoelectrochemical (PEC) sensor. A PEC sensor for the determination of amlodipine besylate (AB) was developed for the first time based on the principle of precipitation reaction between heavy metal ions and dihydropyridine and the recombination suppression effect of the material. The morphology and optical properties of the MnC 4 Pc-ZnO composites were characterized by scanning electron microscopy (SEM) and ultravioletvisible diffuse reflectance spectroscopy (UV-vis DRS). Chronoamperometry (i-t) and electrochemical impedance spectroscopy (EIS) were used to study the PEC behavior of ITO electrodes modified by MnC 4 Pc-ZnO composite material. The study found that the MnC 4 Pc-ZnO composite material has a good photocurrent response to AB, and there was a good linear relationship between the concentration range of 75 nM-250 μM, the linear equation was I(μA) = À 5.2 × 10 À 8 × lgC + 3.2 × 10 À 8 (r = 0.9947), a limit of detection (LOD) of 20 nM. In addition, MnC 4 Pc-ZnO/ITO also has good selectivity and stability. The PEC sensor detects amlodipine besylate tablets, amlodipine besylate dispersible tablets, and biological samples, with standard addition recovery rates of 96.11 % and 103.96 %, respectively. The determination result has good accuracy, and the PEC sensor provides a new method for detecting AB.

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Determination of amlodipine and atorvastatin mixture by different spectrophotometric methods with or without regression equations

Cited by 23 publications

References 22 publications

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC₄Pc Coated ZnO Composite Materials

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Determination of amlodipine and atorvastatin mixture by different spectrophotometric methods with or without regression equations

Cited by 23 publications

References 22 publications

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC4Pc Coated ZnO Composite Materials

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A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC₄Pc Coated ZnO Composite Materials