Determination of amoxicillin content in powdered pharmaceutical formulations using DRIFTS and PLS

Abstract

The amount of amoxicillin in pharmaceutical formulations was determined using spectra of diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS)

Attenuated total reflectance with Fourier transform infrared spectroscopy (ATR/FTIR) and different PLS Algorithms for simultaneous determination of clavulanic acid and amoxicillin in powder pharmaceutical formulation

“…[12][13][14][15][16][17] The use of Fourier transform infrared spectroscopy can supply with these characteristics, mainly when associated to reflection techniques, such as attenuated reflection. Attenuated total reflectance/Fourier transform infrared spectroscopy (ATR/FTIR) has been suggested as a sensible technique to analyze pharmaceutical formulations such as solids, semi-solids and liquids.…”

Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of β-Lactam Antibiotics

“…Non-destructive investigations of -lactam analogs, did not producing residues, were reported in fields of many spectrophotometric methods. A few methods of determination of -lactam analogs were developed by using infrared spectrophotometry enriched by chemometric procedures [5][6]. Most of all analytical methods for the determination of -lactam analogs were developed in range of visible and ultraviolet radiations.…”

Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method

“…4 Its mechanism of action is associated principally with the inhibition of prostaglandin synthesis (specifically, inhibition of cyclooxygenase). 5,6 Different methods for the quantitative determination of these drugs in pharmaceutical preparations and biological fluids have been reported, including UV-vis spectroscopy, [7][8][9][10][11][12][13][14][15][16][17] UV spectroscopy with chemometric analysis, [18][19][20] spectrofluorometry, [21][22][23][24] potentiometry, [25][26][27][28][29] chromatography, 30-37 electrophoresis capillary, [38][39][40][41][42] Fourier transform spectroscopy, 43 FT-Raman spectroscopy, 44 FT-Raman spectroscopy with chemometric analysis, 45 and sequential flow injection; 46,47 however, none of the above procedures is suitable for the simultaneous determination of amoxicillin trihydrate (AMT) and DIC in commercial tablet pharmaceutical preparations. The instrumental methods above mentioned are important referential methods, but are based on expensive analytical instruments, which are not available for laboratories that carry out routine quality controls and have low economic resources.…”