Determination of aniline and related mono-aromatic amines in indoor air in selected Canadian residences by a modified thermal desorption GC/MS method

Zhu, Jiping; Aikawa, Bio

doi:10.1016/s0160-4120(03)00168-5

Cited by 51 publications

(38 citation statements)

References 13 publications

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“…In this study the average ratios of indoor/ambient (Gangnam St.) of particle bound 3-EA in home and office were less than 1. The results are consistent with a previous study reported the indoor/outdoor ratio of aniline (0.93) in Canada (Zhu & Aikawa, 2004).…”

Section: Discussionsupporting

confidence: 93%

“…The results in this study demonstrate improved sensitivity to detect these aromatic amines using a GC/MS compared to previous studies. For example, Research by Zhu and Aikawa (2004) reported LOQ values for 2-EA and 4-EA of 10 ng/m 3 and 20 ng/m 3 , respectively (Zhu & Aikawa, 2004), Another study by Zhu, Newhook, Marro and Chan (2005) reported a method detection limit of 1.2 µg/m 3 for 3,5,-DMA (Zhu, Newhook, Marro, & Chan, 2005). The desorption efficiency in this study was similar to other studies.…”

Section: Discussionsupporting

confidence: 86%

“…The desorption efficiency in this study was similar to other studies. For instance, NIOSH PV2079 method reported average desorption efficiency of 92% for aniline and other environmental monitoring studies also reported desorption efficiency ranges between 92 and 114% for some of methyl-and ethyl anilines (Akyuz, 2008;Zhu & Aikawa, 2004;Zhu et al, 2005). The storage effects of the filters and sorbent tubes were similar to previous studies.…”

Section: Discussionsupporting

confidence: 78%

“…The storage effects of the filters and sorbent tubes were similar to previous studies. In a Canadian study, Zhu and Aikawa (2004) tested storage effects of desorption tubes spiked with 1 ng of 2-EA and 4-EA (Zhu & Aikawa, 2004) and reported a retention of 60-80% after 5 days of storage.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have tried to measure airborne 2,3-DMA; 3,5-DMA; and 3-EA in general environments worldwide (Palmiotto, Pieraccini, Moneti, & Dolara, 2001;Zhu & Aikawa, 2004;Ning et al, 2005). Furthermore, few studies have successfully detected airborne concentrations of these chemicals due to the absence of a sensitive method that can detect trace levels in the air.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Monocyclic Aromatic Amines in an Urban Air

Han¹,

Lee²,

Eo³

2014

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Personal air exposure to monocyclic aromatic amines (MAA) is a growing concern, in large part, due to their ubiquitous presence in the general environment and their potential health risk for bladder cancer. It is unclear what other sources of airborne MAA are for general population, due to low concentrations in the air. Detecting "trace" levels of MAAs requires a sensitive analytical method and field evaluation. In this study, an analytical method was developed to detect 2,3-dimethylaniline [2,3-DMA]; 3,5-DMA; and 3-ethylaniline [3-EA] in general air environment. During a 12-hr sampling periods, the estimated limit of quantifications (LOQs) were less than 4.13 ng/m 3 for 2,3-DMA; 3,5-DMA; and 3-EA. Desorption efficiencies (recovery rates) were at least 89% with 1 ng of each 2,3-DMA; 3,5-DMA; and 3-EA per tube. The storage effect for three MAAs showed that all three MAAs remained above 60% on the sorbent tubes and filters over 10 days. A field study was conducted in Seoul, Korea to validate sampling method in a real-world busy street with traffic, an office near the same street, and a residential home away from the busy street. Gas-phase 2,3-DMA was detected only in the indoor home sample (3.26±0.60 ng/m 3 ), and 3,5-DMA was not detected in all samples. Particle-bound 3-EA was detected in the street (10.92±4.73 ng/m 3 ), office (9.47±6.11 ng/m 3 ), and residential home (7.53±4.17 ng/m 3 ). The results suggested that the proposed analytical and field sampling methods can useful for environmental exposure assessment of these MAAs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measurement of Monocyclic Aromatic Amines in an Urban Air

Han¹,

Lee²,

Eo³

2014

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Development and validation of a rapid high‐performance liquid chromatography method for the quantification of exenatide

Bachhav¹

2010

Biomedical Chromatography

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The objective was to develop a simple HPLC method to quantify exenatide--a 39 amino acid residue incretin mimetic used in diabetes therapy. To date, only non-validated, sometimes incomplete, gradient methods have been reported in the literature. Isocratic separation was achieved using a C₄ column and a mixed solvent system, A-B-C (48:45:7, v/v/v; pH* 5.2), where A represents KH₂PO₄ (pH 4.5; 0.1 M) and MeCN (60:40, v/v), B corresponds to NaClO₄ ·H₂O (pH 6.0; 0.2 M) and MeCN (60:40, v/v), and C is water. Exenatide eluted at 3.64 min and the total run time was 6 min. The method was specific and the response was accurate, precise and linear from 0.75 to 25 µg/mL. It was used to quantify exenatide transport across intact and laser-porated porcine skin in vitro as a function of laser fluence [0 (i.e. intact skin), 9 and 15 J/cm², respectively]. Although no permeation was observed using intact skin, cumulative exenatide permeation after 8 h through laser porated skin was 9.6 ± 6.5 and 12.4 ± 6.4 µg/cm² at fluences of 9 and 15 J/cm², respectively. This is the first validated isocratic method for exenatide quantification and it may be of use in quality control analysis and with other biological matrices.

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CZE study on adsorption processes of aliphatic and aromatic amines on PMMA chip

et al. 2013

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Adsorption processes on a PMMA chip linked with CZE separations of a group of 13 aliphatic and aromatic mono- and di-amines were studied. Due to the lack of chromophores within aliphatic amines, contact conductivity detection implemented directly onto the chip was used for monitoring of cationic CZE separations. To prevent an adsorption of studied amines to the chip channels, the surface of PMMA chip was modified by dynamic coating. Different surface modifiers, such as aliphatic oligoamines (diethylenetriamine and triethylenetetramine), were added to the BGE solutions filling the chip channels. The effect of various concentrations of surface modifiers on peak profiles and separation parameters of amines was monitored. Of these, mainly, aliphatic di-amines and aromatic mono-amines adversely affected the CZE resolution of a whole group of analytes by their strong adsorption to the chip channels. A propionate BGE with pH 3.2 containing 100 μM triethylenetetramine and 25 mM 18-crown-6-ether was found suitable for CZE resolution of 12 from a total of 13 amines studied. Simple dynamic modification of the surface of PMMA chip enabled fast (analysis time lasted 9 min), sensitive (sub-μM LODs reached) and reproducible (1-3% RSD of the peak areas) CZE analysis of the aliphatic and aromatic amines.

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Determination of aniline and related mono-aromatic amines in indoor air in selected Canadian residences by a modified thermal desorption GC/MS method

Cited by 51 publications

References 13 publications

Measurement of Monocyclic Aromatic Amines in an Urban Air

Measurement of Monocyclic Aromatic Amines in an Urban Air

Development and validation of a rapid high‐performance liquid chromatography method for the quantification of exenatide

CZE study on adsorption processes of aliphatic and aromatic amines on PMMA chip

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