Determination of Atomoxetine Hydrochloride in Biological Fluids Using Potentiometric Carbon Paste Electrode Modified by TiO2 Nanoparticles

Shawish, Hazem M. Abu; Saadeh, Salman M.; Tamous, H.; Tbaza, Ahmad

doi:10.17344/acsi.2018.4383

Cited by 13 publications

(8 citation statements)

References 53 publications

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“…The influence of the ion-associating reagent in the preparation of the complex, which is the major component of a membrane for an ISE, was investigated. PTA and PMA are two ion-associate reagents used to prepare ion-pair complex with drugs containing nitrogenous basic group (Ezzeldin et al, 2012;Issa and Khorshid, 2011;Hefnawy et al, 2014;Shawish et al, 2018;Al-Mohaimeed et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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Background: Lisinopril (LNP) is an angiotensin-converting enzyme inhibitor used as anti-hypertensive, cardiovascular, in anti-prophylactic and anti-diabetic nephropathy drug. Development of two new, simple, low cost, and selective membrane-based ion-selective electrodes has been proposed for the determination of LNP in pharmaceuticals. Methods: The electrodes are based on poly(vinyl)chloride membrane doped with LNP-phosphotungstic acid (LNP-PTA) and LNP-phosphomolybdic acid (LNP-PMA) ion-pairs as molecular recognition materials. Results: The developed LNP-PTA and LNP-PMA electrodes are applicable for the determination of LNP over the linear range of 5 × 10 −5 -2.4 × 10 −3 mol l −1 . The working pH ranges to measure potentials were 2.5 to 6.4 and 2.3 to 6.0 for LNP-PTA and LNP-PMA ISEs, respectively. The electrodes displayed the rapid Nernstian responses as revealed by the values of slopes 55.06 and 52.39 mV/decade, with limit of detection (LOD) values of 1.2 × 10 −5 and 1.18 × 10 −5 mol l −1 for LNP-PTA and LNP-PMA electrodes, respectively. The limits of quantitation (LOQ) values have also been calculated for both the electrodes. The developed electrodes have potential stability for up to 1 month and emerged as highly selective for the determination of LNP over other spiked ions and compounds. Conclusions: The proposed electrodes have been validated and found that they are suitable for the determination of LNP in pharmaceuticals in pure form and in dosage forms. The results obtained in the analysis of LNP using proposed electrodes have been compared statistically with reference method's results to assess the accuracy and precision. Robustness and ruggedness of the developed electrodes have also been checked and found satisfactory. The recovery studies have been performed by standard addition procedure to assess the role of excipients in tablets containing LNP and the results obtained are satisfactory.

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Section: Resultsmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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“…Carbonpaste electrodes (CPEs) have several advantages of very low Ohmic resistance, low cost, very short response time , reproducibility of the preparation process, very simple, cheep and quick preparation process. Which provide the possibility of measurements on small volumes as well as ability for construction of a portable titration system for Feld titration of drug [16,17]. These electrodes are commonly used for potentiometric measurements; however, they are also applicable in coulometry (potentiometry) [18,19].…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive electrochemical sensor determination of drug in pharmaceutical analysis

2020

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M ODIFED carbon paste electrodes and screen printed electrodes were developed for the potentiometric determination of butenaFne hydrochloride (BTFHC) in urine, serum and pharmaceutical preparations. Two modiFed carbon paste electrodes (electrodes A and C) and two modiFed screen printed electrodes (electrodes B and D) using tricresylphosphate (TCP) and o-nitrophenyloctyl ether (o-NPOE) plasticizers, respectively, were used. The electrodes showed a linear concentration range from 1.57×10-7 to 1.0 × 10-2 and 1.0 × 10-7 to 1.0 × 10-2 mol L-1 with detection limit of 1.57×10-7 and 1.0 × 10-7 mol L-1 for modiFed carbon paste (MCPEs; electrodes A and B) and modiFed screen printed (MSPEs; electrodes C and D), respectively. The calibration graphs have slope values of 56.95±0.56, 58.22±0.78, 56.18±0.66 and 57.69±0.39 mV decade-1 for electrodes A, B, C and D, respectively. The response time was relatively quick in the whole concentration range and was found to be 12s for electrodes (A and B) and 7s for electrodes (C and D). The electrodes were found to have life time of 82, 99, 160 and 185 days without showing any deviations in a pH range of 5.0-9.0 and 4.0-9.0 for MCPEs (electrodes A and B) and MSPEs electrodes (C and D), respectively. The fabricated electrodes displayed good selectivity for BTFHC with respect to number of common foreign inorganic cations, sugar species, organic and glycine as the Fllers that may be added to the pharmaceutical preparation or biological fluids. Fortunately, such materials mostly do not interfere. The potential application of the sensors (A-D) was accomplished as a result of good recoveries made from real samples fortiFed with BTFHC. Results indicated the proFciency of the sensors reliable for rapid, onsite monitoring of BTFHC in pharmaceutical preparation and in biological samples.

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“…Titanium Dioxide (TiO 2 ) is a biocompatible and stable material, 1 and has a wide range of application in various kinds of cosmetics. TiO 2 is accepted as food additive and also approved by Food and Drug Administration to be used in toothpaste, oral formulations etc.…”

Section: Introductionmentioning

confidence: 99%

Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

Nandi¹,

Mishra²,

Sahoo³

et al. 2020

ACSi

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Titanium dioxide can adhere with human epithelial cells and have good tolerability. Present work has been undertaken to explore the influence of TiO2 on mucosal permeation of aceclofenac. Mucosal permeation of aeclofenac solution containing TiO2 has been carried out. In fourier transform infrared spectrosopy (FTIR), the intensity of the peaks has decreased along with the increase of TiO2 content in the formulation indicating a possible binding between drug and TiO2. Melting enthalpy has been decreased with the increased content of TiO2 in the solid. The status of crystal strain and dislocation density of TiO2 and aceclofenac in the solid state formulation has also been evaluated from Xray Diffraction data using Debye-Scherrer’s equation. Mucosal permeation of aceclofenac has shown sustained effect for more than 20 h in presence of titanium dioxide. Titanium dioxide could be used in designing formulation for sustaining mucosal aceclofenac delivery after performing risk assessment study.

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Determination of Atomoxetine Hydrochloride in Biological Fluids Using Potentiometric Carbon Paste Electrode Modified by TiO2 Nanoparticles

Cited by 13 publications

References 53 publications

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Highly sensitive electrochemical sensor determination of drug in pharmaceutical analysis

Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

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