Determination of benoxaprofen [2-(4-chlorophenyl)-α-Methyl-5-benzoxazoleacetic acid, lrcl 3794] in biological fluids

Chatfield, David H.; Woodage, Trevor J.

doi:10.1016/s0021-9673(00)89860-x

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…After reaching a peak, the mean plasma concentrations fell slowly. The mean plasma half-life was found to be long, in most subjects between 30-35 h, although a considerably longer half-life was recorded in some individuals (Chatfield, Tarrant, Smith & Speirs, 1977). The related areas under the 0-72 h mean plasma level curves were 397, 940 and 1480 jig h ml-', indicating a reasonably linear dose-response in absorption over this dosage range.…”

Section: Single-dose Studiesmentioning

confidence: 76%

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Preliminary studies of absorption and excretion of benoxaprofen in man.

Smith¹,

Goulbourn²,

Burt³

et al. 1977

Brit J Clinical Pharma

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1 Benoxaprofen is a new acidic anti‐inflammatory compound which was well absorbed after oral administration to man. 2 Single doses of 100, 200 and 400 mg produced mean peak concentrations in the plasma of 13.0, 33.5 and 45.3 microgram respectively, and the plasma half‐life of the compound was between 30 and 35 hours. 3 Multiple dosing with 25 and 50 mg every 24 h achieved an equilibrium conentration in the plasma after 6‐8 days, while dosing with 100 mg every 12 h enabled equilibrium to be reached in 3‐6 days. Plasma concentrations between 35 and 45 microgram/ml were achieved by giving 100 mg doses every 12 hours. 4 Absorption of benoxaprofen was delayed when the drug was given with food, but the total amount absorbed remained the same. 5 The effect of milling the material to small particle size (19 micron) was to increase the rate of absorption compared to that of unmilled material (58 micron). 6 Benoxaprofen was well tolerated by healthy male subject in the doses given.

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Section: Single-dose Studiesmentioning

confidence: 76%

“…The levels of benoxaprofen in plasma and urine samples were assayed by gas chromatography using flame ionization for detection of the methyl ester derivative. The method will be described in detail elsewhere (Chatfield & Woodage, 1977), and has a sensitivity down to 0.1 jIg/ml.…”

Section: Assay Ofbenoxaprofenmentioning

confidence: 99%

Preliminary studies of absorption and excretion of benoxaprofen in man.

Smith¹,

Goulbourn²,

Burt³

et al. 1977

Brit J Clinical Pharma

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“…Assay of benoxaprofen. The concentration of benoxaprofen was assayed according to the method described by Shatfield & Woodage (13) Statistics. The data accumulated from the study was expressed as means and SO.…”

Section: Antibody-dependenr Cell-mediated Cytotoxicity (Adcc)mentioning

confidence: 99%

Normalization of monocyte chemotaxis precedes clinical resolution of psoriasis treated with benoxaprofen

Kragballe,

Ternowitz,

Herlin

1985

Acta Derm Venereol

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Enhanced monocyte activity is present in psoriasis, and benoxaprofen is a drug that inhibits several aspects of monocyte function. To assess a potential pathogenic role of enhanced monocyte function in psoriasis, we determined monocyte chemotaxis and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) at week 0, 2, 4 and 8 in psoriatics being treated with benoxaprofen. In patients responding to benoxaprofen, normalization of monocyte chemotaxis occurred at week 4, before clinical resolution took place. A significant decrease of monocyte ADCC was also present at week 4, but it was only at week 8, when psoriasis had completely cleared, that monocyte ADCC was completely normalized. In patients receiving placebo or receiving benoxaprofen, but showing no or minimal clinical improvement, monocyte functions remained increased. These results are compatible with the idea that benoxaprofen may improve psoriasis by interfering with monocyte function.

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