Determination of best Regime for Administration of Atropine Eye Drops for Cycloplegia

Abstract

Purpose: To determine the best regime for administration of atropine eye drops for cycloplegia and to see the effect of cycloplegia on different types of refractive error. Methods:This cross-sectional study was conducted in Pediatric Clinic, Mayo Hospital Lahore, Pakistan in the duration of 3 months to assess the best regime for administration of 1% atropine eye drops for cycloplegia and to see the effect of cycloplegia on different types of refractive error. Non probability purposive sampling was done and 30 patients of age between 0 to 12 years were assessed using a self designed performa. Patients who required cycloplegic refraction were examined after installation of atropine 1 drop for 1 day and 3 drops for 3 days by auto refactometer and retinoscopy. Results were compared to find out the difference in refractive error and the effect of cycloplegia on myopes and hyperopes. Results:The results showed that most of the patients had no difference in refractive error between one day of atropine instillation as compared to three days. Few patients showed little difference of +/-0.25 D after three days. Hyperopic patients showed less difference in refractive error found between first and third day of atropine instillation as compared to myopic patients. Conclusion:Atropine is an efficient cycloplegic drug and we can get effective cycloplegia on first day with even one drop of atropine instillation. This may be beneficial for both the practitioner and children while doing cycloplegic refraction. It will greatly reduce the waiting time for parents and children. It will also lessen the adverse effects of atropine and allow for a better clinical service.

Pharmacologic Mydriasis and Cycloplegia: A Review of Novel Delivery Devices

“…22 Atropine is an anti-muscarinic agent and the most potent cycloplegic agent available. 23,24 Given its comparatively longer duration of action of 1-2 weeks, it is less commonly used. Its side-effect profile includes allergic reactions with conjunctivitis, eyelid oedema and allergic dermatitis, which may be more common with atropine compared with other cycloplegics.…”

Spectrophotometric Determination of Trace Quantities of Pure Atropine and Pharmaceutical Preparations with SbI₄²⁻ Ion

“…For this reason, a number of research groups and scientists, including chemists and pharmacists, are working together to establish a valid procedure to estimate a trace amount of ATR, which leads to learning more about ATR, as well as the numerous analytical methods for determining trace amounts, following simple and rapid steps, and understanding its features. As a result, the concept of research was born [1][2][3][4][5].…”