Determination of binary competitive equilibrium isotherms from the individual chromatographic band profiles

James, François; Sepúlveda, Mauricio; Charton, Frédéric; Quin̄ones, Igor; Guiochon, Georges

doi:10.1016/s0009-2509(98)00539-9

Cited by 93 publications

(41 citation statements)

References 21 publications

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“…The process parameters for Varicol (feed, eluent, raffinate, extract and recycling flow rates) were calculated by HELP 10.3 software from NOVASEP®, which is based on a competitive Langmuir model modified to include a correction term for solution concentration (James et al, 1999).…”

Section: Overload Experiments and Software Simulationmentioning

confidence: 99%

“…The injection of different volumes provided overload chromatograms ( Figure 5) that allowed the evaluation of the interactions between the enantiomers and the chiral stationary phase. After determining the chromatographic parameters and the overloaded elution profiles for the enantiomeric mixtures of verapamil, it was possible to calculate the operating parameters (feed, eluent, raffinate, extract and recycle stream flow rates), column distribution and overall switching time of the streams used in the Varicol system using the program HELP® 10.3, which is based on a competitive Langmuir model modified to include a correction term for the solution concentration (Seidel-Morgenstern, 2004;James et al, 1999). The operating parameters are shown in Table 2.…”

Section: Operating Conditions For the Varicol Systemmentioning

confidence: 99%

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Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Cremasco

Santana²

2015

Braz. J. Chem. Eng.

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-Verapamil is a chiral drug that is marketed in its racemic form, but because of the pharmacological effects due to molecule's chirality, one of the enantiomers is more potent, and the other exhibits different activities of therapeutic interest. The preparative separation of the verapamil enantiomers was performed using a continuous Varicol unit operated on a scale of 1 g/day. Amylose tris(3,5-dimethylphenylcarbamate) functioned as the stationary phase, and n-hexane/isopropanol/ethanol mixtures were used as the mobile phase. Diethylamine was used as the additive. The enantiomeric purities were 93.0% for S-(-)-verapamil and 92.0% for R-(+)-verapamil in the raffinate and extract streams, respectively. The unit provided productivities of 0.18 kg of raffinate per day per kg of adsorbent and 0.20 kg of extract per day per kg of adsorbent when using a feed concentration of 12.5 g L -1 .

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Section: Overload Experiments and Software Simulationmentioning

confidence: 99%

Section: Operating Conditions For the Varicol Systemmentioning

confidence: 99%

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Cremasco

Santana²

2015

Braz. J. Chem. Eng.

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“…The retention times of five overloaded chromatograms were inserted into the software HELP® which is based on the competitive Langmuir model adapted to include a correction term for solution concentration according to the procedure described by [15]. The general form of the isotherm equation is as follows:…”

Section: Chromatographic Parameters and Nonlinear Isothermmentioning

confidence: 99%

“…Isotherm plots generally deviate from linear behavior for various reasons, mainly related to the saturation and/or heterogeneity of the surface or to adsorbate-adsorbate interactions in the bulk fluid and/or close to the surface [15]. The consequences of the nonlinear behavior for the profiles of www.cet-journal.com chromatographic bands are well known.…”

Section: Adsorption Isothermsmentioning

confidence: 99%

Chromatographic Separation and Purification of Mitotane Racemate in a Varicol Multicolumn Continuous Process

et al. 2011

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The multicolumn continuous chromatographic separation process that increases throughput, purity, and yield compared to batch chromatography is considered as an important preparative technique to purify pharmaceutical drugs. Mitotane is a chiral drug marketed in the racemic form but pharmacological effects due to molecule chirality indicate that one of the enantiomers is more potent. Preparative separation of the mitotane enantiomers was performed by a continuous Varicol unit operated on a scale of 30 g/day. Amylose tris(3,5-dimethylphenylcarbamate) functioned as the stationary phase and acetonitrile-isopropanol mixtures as mobile phases. The enantiomeric purities obtained were 97.0 % for S-(-)-mitotane and 96.8 % for R-(+)-mitotane in the raffinate and extract streams, respectively. The unit provided productivities of 1.14 kg raffinate per day and kg adsorbent and 0.68 kg extract per day and kg adsorbent.

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“…Yu et al [16] and Ziyang et al [17] have estimated adsorption equilibrium constants and kinetic parameters using GA. James et al [18] estimated adsorption isotherms coefficients with the conjugate gradient method, and Zhang et al [19] used a variation of GA for the same purpose.…”

Section: Introductionmentioning

confidence: 99%

Solution of an inverse adsorption problem with an epidemic genetic algorithm and the generalized extremal optimization algorithm

Cuco

Neto

Velho

et al. 2009

Inverse Problems in Science and Engineering

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In the present work two recently developed stochastic methods, the epidemic genetic algorithm and the generalized extremal optimization algorithm are used for the solution of an inverse mass transfer problem, which is implicitly formulated as an optimization problem, for the estimation of parameters associated with the adsorption of biomolecules in resin beds. The estimates obtained with both methods present good accuracy, even in the presence of noisy data, provided that the model and experiment used are sensitive to the parameters being estimated. With Thomas' model for the direct mass transfer problem and real experimental data for lisozyme in adsorption columns, it is possible to estimate the maximum adsorption capacity in Langmuir's adsorption isotherm.

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Determination of binary competitive equilibrium isotherms from the individual chromatographic band profiles

Cited by 93 publications

References 21 publications

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Chromatographic Separation and Purification of Mitotane Racemate in a Varicol Multicolumn Continuous Process

Solution of an inverse adsorption problem with an epidemic genetic algorithm and the generalized extremal optimization algorithm

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