2008
DOI: 10.1016/j.apradiso.2007.08.017
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Determination of biological vector characteristics and nanoparticle dimensions for radioimmunotherapy with radioactive nanoparticles

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Cited by 11 publications
(10 citation statements)
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“…The MCNPX code is capable of studying the electron transport through matter by taking into account the loss of energy, multiple scattering angles, and “bremsstrahlung.” All these physical processes are considered by using the photon-electron mode and the default PHYS cards for electron and photons. When the different types of radiations emitted per disintegration are taken into account, the total absorbed dose to medium was determined by formula (1) [31]:Dr=21.34×Etotr×1ρ×Aλeff;Etot=false∑iEir×pi,where E tot ( r ) is the total deposited energy per unit of volume and per disintegration for the different distances “ r ” from the tumour centre determined by using the SMESH tally from MCNPX. This tally builds virtual concentric spherical shells superimposed on the geometry of the tumour surrounded by healthy lung tissues and defines the average energy, in MeV/cm³, and per emitted particle (electron or gamma) deposited into each shell located at different distances “ r ” from the tumour centre [14, 15].…”
Section: Methodsmentioning
confidence: 99%
“…The MCNPX code is capable of studying the electron transport through matter by taking into account the loss of energy, multiple scattering angles, and “bremsstrahlung.” All these physical processes are considered by using the photon-electron mode and the default PHYS cards for electron and photons. When the different types of radiations emitted per disintegration are taken into account, the total absorbed dose to medium was determined by formula (1) [31]:Dr=21.34×Etotr×1ρ×Aλeff;Etot=false∑iEir×pi,where E tot ( r ) is the total deposited energy per unit of volume and per disintegration for the different distances “ r ” from the tumour centre determined by using the SMESH tally from MCNPX. This tally builds virtual concentric spherical shells superimposed on the geometry of the tumour surrounded by healthy lung tissues and defines the average energy, in MeV/cm³, and per emitted particle (electron or gamma) deposited into each shell located at different distances “ r ” from the tumour centre [14, 15].…”
Section: Methodsmentioning
confidence: 99%
“…A recent study compared the dosimetry of internal radiotherapy using nanoparticles labeled with different isotopes such as β-emitters ( 90 Y and 32 P, t 1/2 : 14.3 days) and low-energy X-ray radionuclides ( 103 Pd, t 1/2 : 17.0 days) [125]. It was found that for β-emitter-labeled nanoparticles, a set of data (e.g.…”
Section: Cancer Therapy With Radiolabeled Nanoparticlesmentioning
confidence: 99%
“…37 eff is given by the sum of the physical decay and the biological clearance rate constants ͑ eff = phy + biol ͒. 6,36 The physical half-life of yttrium-90 is well-known and corresponds to 64.1 h. [38][39][40] Based on pharmacokinetic studies on 90 Y, Wiseman and co-workers 41 estimated that the biological blood half-life of the antibody varies between 22 and 140 h. For our simulation, we supposed a biological half-life for healthy tissues of about 72 h. 42,43 Clearance of the antibodies inside the tumor must be slower than in healthy tissues. But due to the short physical half-life of yttrium-90, the biological half-life in the tumor is mainly determined by the physical half-life of yttrium-90.…”
Section: Iib Absorbed Dose Calculationsmentioning
confidence: 99%