Determination of bismuth in urine and prescription medicines using atomic absorption with an on-line hydride generation system

Cadore, Solange; Anjos, Aparecida Pereira dos; Baccan, Nivaldo

doi:10.1039/a804177f

Cited by 22 publications

(10 citation statements)

References 9 publications

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“…The calibration curve was determined under the optimized conditions. The method for determining Bi 3+ in the present study was compared with those reported in the literature (Table 2), including the fluorescence method, 21 various types of atomic absorption spectroscopy, 4,22,23 resonance light scattering, 10 fluorescence quenching, 24 and ultraviolet visible (UV-Vis) spectroscopy. 25 Compared to these established techniques, the method developed in this study has advantages that are not simultaneously provided by the other methods, such as a low detection limit, a wide linear range, and a good linear relationship (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

“…The content of bismuth is a key indicator for the quality control of gastric drugs. Common methods to detect bismuth ions include titration, atomic absorption spectroscopy, [4][5][6] atomic fluorescence spectroscopy, 7,8 electrochemical analysis, 9 resonance light scattering, 10 and mass spectrometry. 11 However, flaws exist in these methods, such as complex operation, low sensitivity, and narrow linear ranges.…”

Section: Introductionmentioning

confidence: 99%

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Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

Guo

Huang

et al. 2016

Appl Spectrosc

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Tetrasulfonated aluminum phthalocyanine (AlSPc), a strongly red-emitting compound, shows high detection sensitivity, little effect of photobleaching, and photochemical stability, making it an excellent red-fluorescent probe. We have observed that in acid media, a low concentration of poly-L-lysine (PLL) has a strong fluorescence-quenching effect on AlSPc, forming the ion-pair complex as AlSPc-PLL with almost no fluorescence. However, in the presence of Bi, the fluorescence of AlSPc-PLL dramatically recovers and the emission is visual because of the remarkable recovery. Screening experiments with other metal ions reveal that only Bi can restore the fluorescence of the AlSPc-PLL complex. The presence of other metal ions does not result in the recovery of fluorescence, indicating the high specificity of the response to Bi of AlSPc-PLL. This is the key finding of the present study. It was also observed that the response to Bi of AlSPc-PLL exhibits a linear relationship over a large concentration range (three orders of magnitude). Based on these findings, we have established a new quantitative analysis method for Bi with high specificity and high sensitivity, using the ion-pair AlSPc-PLL complex as a red-fluorescent probe, and we discuss the reaction mechanism. The detection limit of this method is 0.0021 mg L The linear relationship applies to the range of 0.007-34.9 mg L with a correlation coefficient of 0.9993. The method established addresses the complex operation and time-consuming problems in traditional methods and is thus suitable for real applications. Satisfactory results have been obtained when the method was applied to the measurement of real samples. This study further expands the scope of new applications of phthalocyanine-based red-fluorescent probes in analytical sciences.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

Guo

Huang

et al. 2016

Appl Spectrosc

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“…Existem, na literatura, inúmeras aplicações da técnica de geração de hidretos com detecção por espectrometria atômica, em uma ampla variedade de amostras: alimentos (As) [163][164][165][166] ; água (As) 6,[167][168][169][170][171][172] , (Pb) 173 , (Sn) 174 , (Sb) [175][176][177] , (Se) [178][179][180] , (Tl) 181 , (As e Se) 182 , (As, Se e Sb) 183 , (As, Se, Sb e Ge) 184 ; água e solo (Pb) 185 , amostras ambientais (As) 186 , (Cd) 187 , (Sb) 188,189 , (Sn) 190 ; amostras biológicas (Se) 7 , (As e Bi) 191 ; amostras biológicas e ambientais (As) 192 , (Cd) 193 , (As e Se) 194 ; amostras clíni-cas: cabelo (Se) 195 , (Sb) 196 , urina (As) [197][198][199][200][201] , (Bi) 202 , (Se) 203,205 ; bebidas: vinho (Sb) 206 , vinho e cerveja (As) 207<...>…”

Section: Aplicaçõesunclassified

A geração química de vapor em espectrometria atômica

et al. 2002

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Recebido em 17/9/01; aceito em 29/5/02 CHEMICAL VAPOR GENERATION IN ATOMIC SPECTROMETRY. The historical development of atomic spectrometry techniques based on chemical vapor generation by both batch and flow injection sampling formats is presented. Detection via atomic absorption spectrometry (AAS), microwave induced plasma optical emission spectrometry (MIP-OES), inductively coupled plasma optical emission spectrometry (ICP-OES) , inductively coupled plasma mass spectrometry (ICP-MS) and furnace atomic nonthermal excitation spectrometry (FANES) are considered. Hydride generation is separately considered in contrast to other methods of generation of volatile derivatives. Hg -CVAAS (cold vapor atomic absorption spectrometry) is not considered here. The current state-of-the-art, including extension, advantages and limitations of this approach is discussed.Keywords: chemical vapor generation; atomic spectrometry; batch and flow injection. INTRODUÇÃOO sucesso da espectrometria atômica depende, freqüentemente, do procedimento de introdução da amostra, sendo que o modo mais comum baseia-se na formação de um aerossol líquido, por meio de nebulizadores pneumáticos. Esses dispositivos são de operação simples e conveniente e, por isso mesmo, amplamente utilizados. Entretanto, menos de 10% da solução introduzida é transformada em aerossol útil, sendo sua maior parte, portanto, descartada. Além disso, dificuldades com esses nebulizadores surgem quando são usadas soluções muito viscosas ou com alto teor salino ou, ainda, quando se dispõe tão somente de micro-volumes de amostra 1 .Uma alternativa que se apresenta é a transformação da espécie de interesse em um composto volátil, e seu posterior transporte para a célula de atomização. Quando esta transformação se faz por meio de uma reação química, o processo é conhecido como geração química de vapor. A geração eletroquímica também é citada, embora menos freqüentemente 2-7 . Dois trabalhos podem ser considerados como marcos na geração química de vapor: no primeiro, Hatch e Ott 8 inauguraram a técnica hoje conhecida como "de vapor frio", embora se deva citar os trabalhos anteriores de Poluektov et al. 9,10 Na técnica do vapor frio, o íon mercúrico contido numa solução da amostra é reduzido a mercúrio elementar e assim carreado por uma corrente de gás (ar, N 2 ou Ar), borbulhada através da solução, para a célula de absorção; ou seja, o vapor formado pela reação já é o próprio vapor atômico. O segundo marco na geração de vapor é o trabalho de Holak 11 , onde o arsênio foi reduzido a arsina pela adição, à amostra ácida, de Zn metá-lico, e esta transportada para a chama de um aparelho de absorção atômica. O ganho em sensibilidade observado resulta da maior eficiência de transporte do analito, em comparação com a nebulização pneumática, uma vez que toda a arsina formada pode, em princípio, alcançar o atomizador, carreada por um fluxo de argônio ou nitrogênio e também pelo próprio gás hidrogênio gerado na reação. Entretanto, a atomização do arsênio usando chama convencional apresenta ...

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“…In another work the determination of bismuth in urine and prescription medicines was accomplished using atomic absorption with an on-line hydride generation system with a detection limit for urine samples of 320 ng l 21 . 8 Burguera et al, 9 proposed a method for the determination of bismuth in urine and whole blood samples using on-line flow-injection microwave-assisted mineralization and precipitation/dissolution for electrothermal atomic absorption spectrometry with a detection limit of 8 pg. Recovery values obtained with spiked urine samples were over 96.5%.…”

Section: Introductionmentioning

confidence: 99%

Direct determination of bismuth in urine samples by electrothermal atomic absorption spectrometry: study of chemical modifiers

Magalhães

Nunes

Giacomelli

et al. 2003

J. Anal. At. Spectrom.

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In this work the performance of some chemical modifiers (no modifier, Pd 1 Mg, Ir in solution, Ru, Ir or Zr independently as permanent modifier and Ir 1 Rh permanent) was investigated for the direct determination of Bi in human urine by electrothermal atomic absorption spectrometry (ETAAS). The urine samples were diluted directly in the autosampler cups with one-fold dilution with nitric acid 1% v/v. The obtaining of the permanent modifiers (500 mg of iridium, ruthenium and zirconium independently and 250 mg of Ir plus 250 mg of rhodium) was described elsewhere. Without modifier at all temperatures the signal was negative with a high background. Using Pd 1 Mg the best temperatures were of 1000 and 2500 uC, respectively, for pyrolysis and atomization, but the sensitivity was half that when using Ir 1 Rh. Using ruthenium, iridium or zirconium independently no peak was obtained but a plateau that did not return to baseline even in 15 s of atomization. With iridium applied in solution together with the sample the best pyrolysis and atomization temperatures were of 900 and 2500 uC, respectively, but the sensitivity was analogous with that obtained using Pd 1 Mg. Using Ir 1 Rh, the optimum pyrolysis and atomization temperatures were lower (900 and 1400 uC), but in this case the best sensitivity was obtained with a characteristic mass of 29.2 pg (recommended of 30 pg for the manufacturer for the metal in aqueous solutions). With this modifier, the obtained peak was very symmetrical, returning to the baseline in 3 s with very low background. The use of low temperatures and a low time of atomization coupled to the use of permanent modifer will certainly extend the lifetime of the graphite tube. Aqueous calibration curves and standard addition were parallel with slopes of 0.042 and 0.044 for aqueous and standard addition, respectively. For this reason, the calibration was carried out with aqueous solutions. The r values of calibration curves were higher than 0.99. Spiked urine samples with 5.0, 10.0, 15.0, 20.0, 25.0 and 30.0 mg l 21 , analysed on different days, presented a recovery between 80.0 and 100.0%. The limit of detection was 50 pg. The lifetime of the tube was more than 500 cycles of atomization.

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Determination of bismuth in urine and prescription medicines using atomic absorption with an on-line hydride generation system

Cited by 22 publications

References 9 publications

Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

A geração química de vapor em espectrometria atômica

Direct determination of bismuth in urine samples by electrothermal atomic absorption spectrometry: study of chemical modifiers

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Determination of bismuth in urine and prescription medicines using atomic absorption with an on-line hydride generation system

Cited by 22 publications

References 9 publications

Study of the AlS4Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

Study of the AlS4Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

A geração química de vapor em espectrometria atômica

Direct determination of bismuth in urine samples by electrothermal atomic absorption spectrometry: study of chemical modifiers

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Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application

Study of the AlS₄Pc–Polylysine Ion Pair, a Red-Fluorescent Probe: Its High Specificity, Large Concentration Range Response to Bismuth Ion, and Application