“…To assure the quality of CAP-containing pharmaceutical formulations, several methods have been reported for its determination, including fluorimetric methods (Imai, Toyoka, and Watanabi 1983;Cavrini et al 1988;Al-Ghannam, El-Brashy, and Al-Farhan 2002;Chen and Cai 2003), electrochemical methods (Mohamed, Aboul-Enein, and Gad-kariem 1983;Passamonti, Bartocci, and Pucciarelli 1987;Fraga et al 1998;Passamonti et al 1991;Pimenta, Araújo, and Montenegro 2001;Siangproh, Ngamukot, and Chailapakul 2003;Stefan, Hassan, and Aboul-Enein 2003), AAS (El Walily et al 1999;El Reis, Attia, and Kenawy 2000), chemiluminescence (Xinrong et al 1995;Zhang et al 1995Zhang et al , 1996Economou et al 2002), spectrophotometric methods (Shama, El-Sayed Amin, and Omara 2006;Basavaiah and Nagegowda 2004), capillary electrophoresis (Hillaert and Van den Bossche 1999), and chromatography (Matsuki et al 1980;Drummer, Jarrott, and Louis 1984;Ito et al 1987;Lin Ling et al 1989; Lin Baeyens 1990, 1991;Jankowski et al 1995;Liu et al 1995;Sypniewski and Bald 1996;Kok et al 1997;Ouyang et al 1999;Rao et al 2000;Mirza and Tan 2001). Flow-injection (FI) analysis is a well-established analytical technique that has advantages for routine analysis and quality-assurance control.…”