Determination of catecholamines and metanephrines in urine by capillary electrophoresis–electrospray ionization–time-of-flight mass spectrometry

Peterson, Zlatuše D.; Collins, David C.; Bowerbank, Christopher R.; Lee, Milton L.; Graves, Steven W.

doi:10.1016/s1570-0232(02)00368-9

Cited by 123 publications

(62 citation statements)

References 29 publications

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“…The determination results (mean ± SD) of the examined biogenic amines in human urine from healthy subjects (n =7) were as follows: DOPA 5.4 ± 2.4, DA 5.0 ± 1.6, NE 4.4 ± 1.6, E 1.9 ± 1.1, MN 3.6 ± 1.0, Trp 32 ± 6.5, 5-HTrp 1.4 ± 0.69, and 5-HT 2.6 ± 0.81 nmol/mL urine. These results agree well with previously reported data [8][9][10].…”

Section: Selective Analysis Of Native Fluorescent Biogenic Amines Usisupporting

confidence: 94%

Development of Analytical Methods Utilizing Selectivity of Fluorous Affinity and Their Applications

Hayama¹

2016

Chromatography

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Perfluoroalkyl-containing compounds show a unique "fluorous" property, which is related to the specific affinity, i.e. fluorophilicity, between perfluoroalkyl groups. Therefore, fluorous compounds can be easily and selectively isolated from non-fluorous compounds utilizing liquid-liquid extraction, solid phase extraction, and liquid chromatographic techniques via their fluorophilicity. We have also developed novel methods for the selective analysis of biogenic-related compounds using fluorous separation techniques. These methods involve the attachment of perfluoroalkyl groups to target analytes, followed by their selective separation from endogenous biological matrices with appropriate fluorous separation techniques. Because the perfluoroalkylated compounds are generally not included in biological matrices, highly selective analysis of perfluoroalkyl-attached target analytes is possible. This review summarizes our recent works concerning biogenic-related compound analysis methods using fluorous separation techniques.

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Section: Selective Analysis Of Native Fluorescent Biogenic Amines Usisupporting

confidence: 94%

Development of Analytical Methods Utilizing Selectivity of Fluorous Affinity and Their Applications

Hayama¹

2016

Chromatography

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“…Solid-phase extraction (SPE) with reverse phase, 12,18,19 strong anion exchange, 20 and strong cation exchange 21,22 is a key method for the selective extraction and condensation of target molecules. Liquid-liquid extraction (LLE) 12,23 is also frequently used for metabolite fractionation by solvent partitioning and protein removal.…”

Section: Introductionmentioning

confidence: 99%

A Simple and Highly Sensitive Quantitation of Eicosanoids in Biological Samples Using Nano-flow Liquid Chromatography/ Mass Spectrometry

Ando

Satomi

2018

ANAL. SCI.

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A simple sample preparation method for eicosanoid was developed by the combination of deproteinization and nanoLC-ESI-MS/MS. Eicosanoids are a group of bioactive lipid mediators, present in trace amounts in the body. Therefore, an analytical method for eicosanoids requires superior sensitivity. The method described in this report, which takes advantage of the highly sensitive power of nanoLC-ESI-MS/MS, enabled a simplification of the sample-preparation process. Eicosanoid extraction was performed just by homogenization in methanol with subsequent phospholipid removal, and then the liquid phase was directly subjected to nanoLC-ESI-MS/MS analysis without a condensation process. The quantitation range achieved 0.01 -100 ng/mL for thromboxane B2, and 0.05 -100 ng/mL for prostaglandin E2, prostaglandin D2, prostaglandin F2, leukotriene B4, 6-keto prostaglandin F1α and 11-dehydro thromboxane B2. Rat brain sample analyses demonstrated the feasibility of the quantification of those seven eicosanoids from biological samples.

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“…This is directly affected by a number of external factors such as the intake of certain foods, drinks and drugs, dehydration level and fatigue. 20,21 Numerous methods are available for dopamine determination such as the radio-enzymatic and immunological techniques, 22 high performance liquid chromatography, 23 and capillary electrophoresis. 24 Most of these are time consuming and requires high cost.…”

Section: Introductionmentioning

confidence: 99%

Impact of carbon-fluorine doped titanium dioxide in the performance of an electrochemical sensing of dopamine and rosebengal sensitized solar cells

et al. 2015

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The role of Fluorine and Carbon as dopants in the TiO2 based electrochemical sensor and DSSC were presented in this work. A series of Carbon nano-cones and disc doped TiO2 (TC), Fluorine doped TiO2 (FT) and C & F co-doped TiO2 (CFT) powdered samples were prepared via solid state synthesis. The CFT film showed excellent electrochemical sensitivity to the oxidation of dopamine in aqueous solution and could be employed as a dopamine sensor. The proposed sensor exhibited good linear response in the range of 10-820 μM with a detection limit of 3.6 μM under optimum conditions. The photovoltaic performances of Rose Bengal sensitized solar cells were assessed through I-V measurements. The CFT based DSSC shows a short-circuit current density and a power conversion efficiency (η) of 0.908 mA/cm2 and 0.163% respectively, which is 35% and 38% greater than the performance of other PT based cells. The characterization studies such as UV-Visible spectroscopy, Photoluminescence, TEM and EPR spectroscopy were utilized for further investigation, which helps us to understand how fluorine and carbon play a part in dopamine sensing and solar energy conversion.

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Determination of catecholamines and metanephrines in urine by capillary electrophoresis–electrospray ionization–time-of-flight mass spectrometry

Cited by 123 publications

References 29 publications

Development of Analytical Methods Utilizing Selectivity of Fluorous Affinity and Their Applications

Development of Analytical Methods Utilizing Selectivity of Fluorous Affinity and Their Applications

A Simple and Highly Sensitive Quantitation of Eicosanoids in Biological Samples Using Nano-flow Liquid Chromatography/ Mass Spectrometry

Impact of carbon-fluorine doped titanium dioxide in the performance of an electrochemical sensing of dopamine and rosebengal sensitized solar cells

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