Determination of Ceftiofur Metabolite Desfuroylceftiofur Cysteine Disulfide in Bovine Tissues Using Liquid Chromatography–Tandem Mass Spectrometry as a Surrogate Marker Residue for Ceftiofur

Feng, Shixia; Chiesa, O. A.; Kijak, Philip James; Chattopadhaya, Chaitali; Lancaster, Vicki A.; Smith, E. A.; Girard, Lauren; Sklenka, Sara; Li, Hui

doi:10.1021/jf405423e

Cited by 14 publications

(15 citation statements)

References 22 publications

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“…When possible, a bridging study 69 should be conducted in which results from new methods of extraction should be compared 70 with reference methods in side-by-side analysis of the same sample. 13 However, this is not 71…”

Section: Introduction 24mentioning

confidence: 99%

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Evaluation of Different Parameters in the Extraction of Incurred Pesticides and Environmental Contaminants in Fish

Sapozhnikova

Lehotay

2015

J. Agric. Food Chem.

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Sample processing is often ignored during analytical method development and validation, but accurate results for real samples depend on all aspects of the analytical process. Also, validation is often conducted using only spiked samples, but extraction yields may be lower in incurred samples. In this study, different variables in extraction for incurred pesticides and environmental contaminants in fish were investigated. Among 207 analytes screened using low-pressure gas chromatography-tandem mass spectrometry, consisting of 150 pesticides, 15 polycyclic aromatic hydrocarbons (PAHs), 14 polychlorinated biphenyls (PCBs), 6 polybrominated diphenyl ethers (PBDEs), and 22 other flame retardants (FRs), 35 (16 pesticides, 9 PCBs, 5 PBDEs, and 5 PAHs) were identified for quantification in samples of salmon, croaker, and NIST Standard Reference Material 1947 (Lake Michigan Fish Tissue). Extraction efficiencies using different extraction devices (blending, vortexing, and vibrating) versus time, sample size, and sample/solvent ratio were determined. In comparison to blending results, use of a pulsed-vortexer for 1 min with 1/1 (g/mL) sample/acetonitrile ratio was generally sufficient to extract the incurred contaminants in the homogenized fish tissues. Conversely, extraction with a prototype vibration shaker often took 60 min to achieve 100% extraction efficiency. A main conclusion from this study is that accurate results for real samples can be obtained using batch extraction with a pulsed-vortexer in a simple and efficient method that achieves high sample throughput.

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Section: Introduction 24mentioning

confidence: 99%

“…PAHs, and 2 ng/g for 13 (Restek) was used for low-pressure (vacuum outlet) GC. High purity He was the carrier gas at 170 a constant flow rate of 2 mL/min.…”

Section: Introduction 24mentioning

confidence: 99%

Evaluation of Different Parameters in the Extraction of Incurred Pesticides and Environmental Contaminants in Fish

Sapozhnikova

Lehotay

2015

J. Agric. Food Chem.

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“…However, due to the sophisticated extraction process required for CEF residues, CEF detection using an MRM process was not done prior to 2016. CEF was instead analyzed separately using the 7-plate bioassay for screening, a high-pressure liquid chromatography-ultraviolet detection (HPLC-UV) method to quantify the residue, and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) for confirmation (Feng et al, 2014). Additionally, the KIS TM test replaced an older in-plant screening test.…”

Section: Antimicrobial Residues In Milk and Dairy Beef From Cull Dairmentioning

confidence: 99%

“…In the bovine, the current US tolerance is 0.4 parts per million (400 ng/g), with kidney serving as the marker residue. The method described above has been published as an alternate method to determining DCA in tissues, in which DCCD is measured as a surrogate marker residue for DFC (Feng et al, 2014). In order to convert measured DCCD concentrations to DFC, the following regression equation was utilized:…”

Section: Ceftiofur Concentration Analysis-tissue Samplesmentioning

confidence: 99%

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Impact of disease in dairy cows on ceftiofur pharmacokinetics, withdrawal times and emergence of antimicrobial resistance

Gorden¹

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guidance and support throughout the course of this research. I would also like to thank my two residents over the last four years, Dr. Mike Kleinhenz and Dr. Josh Ydstie for the endless hours of support in helping organize and implement sample and data collection. Additionally, I'd like to thank my colleagues Dr. Troy Brick, Dr. Joe Smith, and Dr. Kelly Still-Brooks for helping cover the workload to get these projects completed. Lastly, Tiffany Magstadt and Eric Hellmich in VFS for helping get everything I needed to get these projects completed. Thank you to all the folks in the PhAST lab, specifically Dr. Larry Wulf, Dr. Suzanne Rajewski, and Dr. David Borts who patiently assisted me through a million questions about LC/MS analysis; to Jackie Peterson who always made sure I had what I needed; and to Dan and Renee for always helping me find what I needed. I appreciate you tolerating me through all the weird hours that I spent in the lab and just checking up on me once in a while.

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Onsite/on‐field analysis of pesticide and veterinary drug residues by a state‐of‐art technology: A review

Rahman

Lee

et al. 2021

J of Separation Science

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Pesticides and veterinary drugs are generally employed to control pests and insects in crop and livestock farming. However, remaining residues are considered potentially hazardous to human health and the environment. Therefore, regular monitoring is required for assessing and legislation of pesticides and veterinary drugs. Various approaches to determining residues in various agricultural and animal food products have been reported. Most analytical methods involve sample extraction, purification (cleanup), and detection. Traditional sample preparation is time‐consuming labor‐intensive, expensive, and requires a large amount of toxic organic solvent, along with high probability for the decomposition of a compound before the analysis. Thus, modern sample preparation techniques, such as the quick, easy, cheap, effective, rugged, and safe method, have been widely accepted in the scientific community for its versatile application; however, it still requires a laboratory setup for the extraction and purification processes, which also involves the utilization of a toxic solvent. Therefore, it is crucial to elucidate recent technologies that are simple, portable, green, quick, and cost‐effective for onsite and infield residue detections. Several technologies, such as surface‐enhanced Raman spectroscopy, quantum dots, biosensing, and miniaturized gas chromatography, are now available. Further, several onsite techniques, such as ion mobility–mass spectrometry, are now being upgraded; some of them, although unable to analyze field sample directly, can analyze a large number of compounds within very short time (such as time‐of‐flight and Orbitrap mass spectrometry). Thus, to stay updated with scientific advances and analyze organic contaminants effectively and safely, it is necessary to study all of the state‐of‐art technology.

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Determination of Ceftiofur Metabolite Desfuroylceftiofur Cysteine Disulfide in Bovine Tissues Using Liquid Chromatography–Tandem Mass Spectrometry as a Surrogate Marker Residue for Ceftiofur

Cited by 14 publications

References 22 publications

Evaluation of Different Parameters in the Extraction of Incurred Pesticides and Environmental Contaminants in Fish

Evaluation of Different Parameters in the Extraction of Incurred Pesticides and Environmental Contaminants in Fish

Impact of disease in dairy cows on ceftiofur pharmacokinetics, withdrawal times and emergence of antimicrobial resistance

Onsite/on‐field analysis of pesticide and veterinary drug residues by a state‐of‐art technology: A review

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