Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

Gumieniczek, Anna; Berecka‐Rycerz, Anna; Mroczek, Tomasz; Wojtanowski, Krzysztof Kamil

doi:10.3390/molecules24244430

Cited by 21 publications

(8 citation statements)

References 28 publications

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“…Metformin is weakly basic in nature (p K a 2.8 and 11.5) and gets ionized in a pH range from 4 to 10 . At pH 4, MTF occurs predominantly in the molecular form which gets trapped at the hydrophobic gas–liquid cavity interface and is hence found more susceptible to degradation resulting in the maximum extent of degradation of MTF by cavitation (95%).…”

Section: Resultsmentioning

confidence: 99%

A Strategy for Complete Degradation of Metformin Using Vortex-Based Hydrodynamic Cavitation

Patil

Thanekar

Bhandari

2022

Ind. Eng. Chem. Res.

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The present work successfully establishes the degradation of metformin, an antidiabetic drug, using vortex flow-based hydrodynamic cavitation (HC) and process intensification. Studies were carried out on a pilot plant (1 m 3 /h) and for high initial concentrations, 10−20 mg/L. Effects of intensifications using aeration and the addition of hydrogen peroxide on various process parameters were evaluated. A low degradation (3−5%) by HC at ΔP of 1 bar could be improved by process intensification using hydrogen peroxide (33%). Importantly, a very high 95% metformin degradation was obtained at pH 4 with excellent cavitational yields up to 162 × 10 −5 mg/J, further extending to 100% the degradation using HC+H 2 O 2 , an order of magnitude enhancement of 900%. The synergy can be drastically enhanced by process modifications. Per pass degradation enhancement was huge, 100 times, corresponding to an order of magnitude cost reduction compared to conventional hydrodynamic cavitation. The established strategy can have positive implications for industrial wastewater treatment.

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Section: Resultsmentioning

confidence: 99%

A Strategy for Complete Degradation of Metformin Using Vortex-Based Hydrodynamic Cavitation

Patil

Thanekar

Bhandari

2022

Ind. Eng. Chem. Res.

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“…Several MT PDs are listed in the literature, but the extent of MT degradation varies considerably. This variation can be explained by the different concentrations of the degrading solutions and the time of exposure to them [33–35]. It was possible to observe the DP7 with the DAD detector, which was related to MT due to its similarity with its UV spectrum (Figures 2 and 4).…”

Section: Resultsmentioning

confidence: 99%

A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms

Júnior

Muniz

Almeida

et al. 2022

J of Separation Science

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Metformin is one of the most commonly used drugs in the world for the treatment of type 2 diabetes, while ferulic acid is a molecule that stands out for its antioxidant potential. Recent studies demonstrate hypoglycemic synergy between these molecules. The objective of this study is to develop and validate an analytical methodology by high‐performance liquid chromatography for the simultaneous quantification of these drugs in pharmaceutical formulations. The method used an octadecylsilane column and a mobile phase composed of 6 mM sodium lauryl sulfate in 15 mM phosphate buffer:ACN (65:35). Ferulic acid and metformin were monitored at 232 nm, with a mobile phase flow rate of 1 ml/min and oven temperature at 40°C. The method was linear in the range of 5–25 μg/ml for both molecules. In the presence of degradation products, satisfactory selectivity was achieved. Accuracy values were close to 100% and standard deviations in precision were less than 2%. In the robustness evaluation, the proposed variations did not interfere with the quantification. Therefore, it is concluded that the present method can be safely applied to the quality control of ferulic acid and metformin raw materials, as well as when they are combined in pharmaceutical formulations.

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“…of repaglinide and metformin. And second, a primary valid technique was LC-UV is examined, whether or not it is valid and determined those drugs within the presence of their own pharmaceutical degradation product and whether or not it's similar for estimating the degradation kinetic process [42].…”

Section: Ramakrishna and Mondalmentioning

confidence: 99%

A Review of Analytical Methods for Determination of Type- Ii Antidiabetic Drugs in Pharmaceuticals and Biological Matrices

Ramakrishna

Mondal

2021

Asian J Pharm Clin Res

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Its a meglitinide analog is an oral symptom designed to common hour aldohexose excursions. Through not an antidiabetic, it acts in AN analogous manner by binding to antidiabetic receptor likewise on alternative one distinct receptor-» closure of adenosine triphosphate dependent K+ channel-» of depolarization-» internal secretion unharnesses. Repaglinide induces fast onset short-lasting internal secretion discharged. It is administered antero every main meal to stabilize postprandial hyperglycemia; the dose ought to be emitted if a food material is incomprehensible. Because of less permanent action, it perhaps had a lower risk of the seriousness of hypoglycemia. Repaglinide is indicated solely in type-II DM as another to sulfonylureas, or to supplement metformin/long internal secretion. It ought to be avoided in disease. This review delivers a detail description totally different of various analytical ways were printed for the estimation of repaglinide and its combination medicine in prescription drugs and biological matrices. This assessment encompasses different analytical ways such as chemical analysis ways, aggressive liquid activity (HPLC), superior thin-layer activity (HPTLC), liquid chromatography-mass spectroscopic analysis (LC-MS), and ultra-performance liquid activity (UPLC), GC-MS, [LC-ESI-MS-MS], capillary activity (CE), titrimetric and chemical science technique, and designation study for the estimation of repaglinide and together with a mixture.

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Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

Cited by 21 publications

References 28 publications

A Strategy for Complete Degradation of Metformin Using Vortex-Based Hydrodynamic Cavitation

A Strategy for Complete Degradation of Metformin Using Vortex-Based Hydrodynamic Cavitation

A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms

A Review of Analytical Methods for Determination of Type- Ii Antidiabetic Drugs in Pharmaceuticals and Biological Matrices

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