Determination of chloramphenicol by coupling a continuous reduction system to an atomic-absorption spectrometer

Montero, R.; Gallego, Mercedes; Valcárcel, Miguel

doi:10.1016/0039-9140(90)80180-n

Cited by 19 publications

(6 citation statements)

References 7 publications

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“…-ESI-MS-MS, 11 liquid chromatography-MS, 12 and GS-MS methods, 13 in addition, other analytical methods included f low injection, 14,15 voltammetry, 16 chemiluminescence 17 atomic absorption spectrometry, 18 and spectrophotometric methods [19][20][21][22][23][24][25][26] were also mentioned.…”

Section: Introductionmentioning

confidence: 99%

Leishman’s Dye as a Novel Reagent in Spectrophotometric Determination of Chloramphenicol

Sabeeh¹

2020

ijddt

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By reviewing the literature, there is no indication concerning the use of Leishman’s dye in evaluating drug compounds by dye-color bleaching; hence, it is the first attempt to use Leishman’s dye as a novel reagent in the estimation of chloramphenicol (CAP) by an indirect spectrophotometric method in bulk and in its pharmaceutical preparations. The method includes the use of a great amount of N-bromosuccinamide (NBS) in the acidic medium as an oxidizing agent of the drug under investigation (CAP), and then using the residual of NBS for Leishman’s dye color bleaching. The absorbance has been measured at 622 nm (the maximum absorption of Leishman’s dye). A linear relationship was obtained for the Beer’s law with the concentration ranges from 10 to 250 μg/10 mL with acceptable values of molar absorptivity 0.58 × 104 L.mol-1.cm-1 and 0.055 μg.cm-2 of Sandell’s sensitivity index, which mean a high sensitivity. An approved estimation of CAP in its various pharmaceutical formulations was found.

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Section: Introductionmentioning

confidence: 99%

Leishman’s Dye as a Novel Reagent in Spectrophotometric Determination of Chloramphenicol

Sabeeh¹

2020

ijddt

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“…Furthermore, its use in food production, such as aquaculture farming, has been banned worldwide [1,6]. Various analytical methods have been used for the determination of Chloramphenicol, which include official method [7,8], chromatography [9,10], ion-selective electrode technique [11], chemiluminescence [12,13], titrimetry [14,15], electrochemical techniques [16], flow-injection biamperometric method [17], atomic absorption spectrometry [18]. Many Spectrophotometric methods, depending on reduction of nitro group, have been reported for determination of chloramphenicol using various reagents such as isonicotinic acid hydrazide [19], N-(1-naphthyl)ethylenediamine [20], trisodium pentacyanoaminoferrate [21], Ninhydrin [22], iminodibenzyl, 3-aminophenol, pyrocatechol and molybdate [23], orthogonal polynomials [24], ammonium molybdate [25] and pdimethylaminobenzaldehyde [26].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations using o-Chloranil Reagent

Al-Ghabsha¹,

Al-Sabha²,

Al-Enizzi³

2013

J.Edu.Sci.

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A simple, sensitive and rapid spectrophotometric method for the determination of chloramphenicol in pure as well as in dosage form is described. The method is based on the reaction of reduced chloramphenicol with o-chloranil in an aqueous alkaline medium to form a purple colored charge transfer complex of maximum absorption peak at 527 nm. Under the optimized reaction conditions, Beer's law correlating the absorbance with chloramphenicol concentration was obeyed in the range of 2-65 μg ml-1 with molar absorptivity 3.72×10 3 L mol −1 cm −1. The limits of detection and quantitation were 0.456 and 1.521 μg ml-1 , respectively.

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“…Furthermore, its use in food production, such as aquaculture farming, has been banned worldwide [1,6] . Various analytical methods have been used for the determination of chloramphenicol, which include official method [7,8] , high-performance liquid chromatography [9][10][11] , gas chromatography [12] , displacement chromatography [13] , ion-selective electrode technique [14] , electrogenerated chemiluminescence [15] , titrimetry [16][17][18] , electrochemical techniques [19] , flow-injection biamperometric method [20] , bioluminescence micro method [21] , enhanced chemiluminescence method employing an online photochemical reaction [22] , atomic absorption spectrometry [23] . Many Spectrophotometric methods, depending on reduction of nitro group, have been reported for determination of chloramphenicol using various reagents such as isonicotinic acid hydrazide [24] , N-(1naphthyl)ethylenediamine [25] , trisodium pentacyanoaminoferrate [26] , Ninhydrin [27] , iminodibenzyl, 3-aminophenol and pyrocatechol molybdate [28] , orthogonal polynomials [29] , ammonium molybdate [30] and p-dimethylaminobenzaldehyde [31] .…”

Section: Introductionmentioning

confidence: 99%

Sensitive Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations Using 7,7',8,8'-tetracyanoquinodimethane reagent

Chemistry¹,

Al-Sabha²

2013

J.Edu.Sci.

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Determination of chloramphenicol by coupling a continuous reduction system to an atomic-absorption spectrometer

Cited by 19 publications

References 7 publications

Leishman’s Dye as a Novel Reagent in Spectrophotometric Determination of Chloramphenicol

Leishman’s Dye as a Novel Reagent in Spectrophotometric Determination of Chloramphenicol

Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations using o-Chloranil Reagent

Sensitive Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations Using 7,7',8,8'-tetracyanoquinodimethane reagent

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