Determination of chloramphenicol in aquatic products by graphene-based SPE coupled with HPLC-MS/MS

Abstract

An effective analytical protocol using graphene-based SPE coupled with HPLC-MS/MS for determination of chloramphenicol (CAP) in aquatic products has been developed. In the present work, graphene was evaluated as SPE sorbents for the analytes enrichment and clean up. The target analytes were quantified by a triple-quadrupole linear ion trap MS in multiple-reaction monitoring mode. In addition, the proposed method was validated according to Commission Decision 2002/657/EC. The calibration curve was linear over the range of 0.5-100 ng/mL. The mean values of RSD of intra- and interday ranging from 1.48 to 4.29% and from 3.25 to 7.42% were obtained, respectively. In the three fortified levels, the recoveries of CAP ranging from 92.3 to 103.4% with RSDs ≤ 5.58% were obtained. The proposed method has been successfully applied to the analysis of CAP in several aquatic product samples, indicating that graphene was a potential SPE sorbent for the enrichment of trace residues in food samples.

Electromembrane‐surrounded solid‐phase microextraction coupled to ion mobility spectrometry for the determination of nonsteroidal anti‐inflammatory drugs: A rapid screening method in complicated matrices

“…As a new class of carbon nanostructures, graphene has received attention because of its extensive surface area and high stability and thus has wide potentials as a sorbent material in SPME . Recently, a composite coating of polypyrole/graphene oxide has been prepared in the presence of SDS as a high thermally stable coating for SPME .…”

Graphene-Based Materials as Solid Phase Extraction Sorbent for Trace Metal Ions, Organic Compounds, and Biological Sample Preparation

“…The developed SPE-GO-MPPS isolated metal ions from complex matrices with less interference. Excellent sensitivity (145)(146)(147)(148)(149)(150)(151)(152)(153)(154)(155)(156)(157)(158)(159)(160)(161)(162) ng L -1 ), great enrichment factor (325), and good recovery (99-103%) were obtained. Selectivity was considered in the presence of various coexisting ions with > 90% extraction recovery.…”

Fabrication of graphene/Fe3O4@polythiophene nanocomposite and its application in the magnetic solid-phase extraction of polycyclic aromatic hydrocarbons from environmental water samples

“…In this regard, G was applied as a sorbent for solid phase extraction (SPE) of different analytes in biological and aqueous samples. It can be employed in small amounts (e.g., 25-35 mg) and also can give quantitative recoveries with the less volume of eluent solvents (e.g., 0.3-1 mL) in comparison with the traditional sorbents such as C 18 silica (e.g., 200-500 mg) [8][9][10][11], because of the good adsorptive properties.…”