Electromembrane‐surrounded solid‐phase microextraction coupled to ion mobility spectrometry for the determination of nonsteroidal anti‐inflammatory drugs: A rapid screening method in complicated matrices

Abstract

A new robust method of electromembrane-surrounded solid-phase microextraction coupled to ion mobility mass spectrometry was applied for nonsteroidal anti-inflammatory drugs determination in complex matrices. This is the first time that a graphene/polyaniline composite coating is applied in electromembrane-surrounded solid-phase microextraction method. The homemade graphene/polyaniline composite is characterized by a high electrical conductivity and thermal stability. The variables affecting electromembrane-surrounded solid-phase microextraction, including extraction time; applied voltage and pH were optimized through chemometric methods, central composite design, and response surface methodology. Under the optimized conditions, limits of detection of 0.04 and 0.05 ng/mL were obtained for mefenamic acid and ibuprofen, respectively. The feasibility of electromembrane-surrounded solid-phase microextraction followed by ion mobility mass spectrometry was successfully confirmed by the extraction and determination of low levels of ibuprofen and mefenamic acid in human urine and plasma samples and satisfactory results were obtained.

High-Quality Metal–Organic Framework ZIF-8 Membrane Supported on Electrodeposited ZnO/2-methylimidazole Nanocomposite: Efficient Adsorbent for the Enrichment of Acidic Drugs

“…Studies regarding the adsorption of acidic drugs have been extensively reported40414243444546. However, only limited investigations used ZIF-8 adsorbent to adsorb acidic drugs.…”

Coupling of multi-walled carbon nanotubes/polydimethylsiloxane coated stir bar sorptive extraction with pulse glow discharge-ion mobility spectrometry for analysis of triazine herbicides in water and soil samples

“…IMS is well suited for large-scale, trace-level investigation and monitoring programs where sophisticated laboratory instrument is not available. A number of literatures have demonstrated the applications of IMS in analysis of explosives [23,24], drugs [25], pharmaceuticals [26], pesticides [27] and other agricultural or industrial contaminants [28].…”

Ultrasound‐assisted magnetic dispersive solid‐phase microextraction: A novel approach for the rapid and efficient microextraction of naproxen and ibuprofen employing experimental design with high‐performance liquid chromatography

“…It is clear that the choice of an appropriate and selective samplepreparation procedure is essential for accurate determination of these drugs [3][4][5][6][7]. SPME is a sample-preparation method that has been applied to a range of applications such as environmental, industrial, clinical, forensic, drug and food analysis [8][9][10].…”