Determination of Chlorantraniliprole Residues in Corn and Soil by UPLC–ESI–MS/MS and Its Application to a Pharmacokinetic Study

Abstract

A rapid, highly sensitive, and selective method was developed for the determination of the insecticide chlorantraniliprole (CAP) in corn and soil using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Samples were extracted with acetonitrile, and aliquots were cleaned with solid-phase extraction cartridges. Two precursor-product ion transitions for CAP were measured and evaluated to provide maximum confidence in the results. Average recovery for soil, corn grain, and corn straw at different levels (5 or 10, 40, and 100 lg kg -1 ) ranged from 74.9 to 97.5%, with intra-day relative standard deviation (RSD) values of 1.9-11.3% and inter-day RSD values of 4.7-10.4%. Coefficients of determination (R 2 ) of 0.9988 or higher were achieved for CAP in soil, corn grain, and corn straw matrix calibration curves, from 5 to 1,000 lg L -1 . The CAP limits of quantitation in soil, corn grain, and straw were determined to be 5, 10, and 10 lg kg -1 , respectively, which were much lower than the maximum residue levels established by the Environmental Protection Agency of United States. UPLC-MS/MS was used to determine the CAP residues in real corn and soil for studies on their dissipation. The trial results showed that the half-lives of CAP changed from 12.6 to 23.1 days in soils and ranged from 4.9 to 5.4 days in corn straws in the districts of Henan and Shandong, and the average levels of CAP residues in corn grains were all \0.01 mg kg -1 with a harvest withholding period of 180 days.

Effect of Different Soil Treatments on Dissipation of Chlorantraniliprole and Dehydrogenase Activity Using Experimental Modeling Design

“…The insecticides tested achieved levels below the MRL of 0.05 mg/kg much faster than their PHIs (ScholzStarke et al 2017). Our results are in agreements with Dong et al who studied the determination of CAP residues in corn and soil by UPLC-ESI-MS/MS and they found that the half-life of CAP ranged from 12.6 to 23.1 days in soils and ranged from 4.9 to 5.4 days in corn (Dong et al 2011). Zhang and other calculated the half-life of CAP in soil of rice field ecosystem to be 16.0 days (Zhang et al 2012).…”

Dissipation Kinetics and the Pre-Harvest Residue Limits of Acetamiprid and Chlorantraniliprole in Kimchi Cabbage Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

“…Acetamiprid has been reported to have a short half-lives in studies of zucchini (1.9 days) [16], chili peppers (2.24–4.84 days) [18], watermelon (3.1–3.9 days) [17], okra fruit (2.3 days) [37], green tea shoots (1.82–2.33 days) [38], and mustard plants (1.02 and 1.59 days) [39]. Previous studies have shown that chlorantraniliprole also tends to degrade rapidly with half-lives of 4.9–5.4 days in corn straw [40], 1.25 and 1.36 days in cauliflower [26], 2.7 days in grape [24], 3.3 days in tomato, and 0.93–1.33 days in berseem leaf. Overall, the dissipation tendencies of both pesticides in this study were slightly slower than those of previous studies.…”

Persistence, dissipation behavior and dietary risk assessment of a combi-product of chlorantraniliprole and λ-cyhalothrin in/on pigeonpea (Cajanus cajan L.)

“…The present finding on DT 50 of chlorantraniliprole is differing from the results reported with DT 50 for cauliflower 1.25–1.36 days ( Kar et al., 2012 ), tomato 3.30 days ( Malhat et al., 2012 ) okra 1.60–1.70 days ( Vijayasree et al., 2015 ), brinjal 1.58–1.80 days ( Vijayasree et al., 2015 ), green chilli 1.58–1.80 days ( Ahlawat et al., 2019 ), 1.26 days ( Paramasivam, 2020 ). This variation might be the resultant of the prevailing environmental factors and processes viz., temperature, relative humidity, volatilization and photo-degradation at field conditions ( Dong et al., 2011 ; Kar et al., 2012 ; Zhang et al., 2012 ; Solanki et al., 2019 ; Paramasivam, 2020 ) which are not consistent in different geographical regions.…”