Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography

Abdelrahman, Amal N.; Karim, Elfatih I.A.; Ibrahim, Kamal E.

doi:10.1016/0731-7085(94)90031-0

Cited by 10 publications

(6 citation statements)

References 2 publications

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“…Few reports are available on assay [7,8], simultaneous determination and enantiomeric separation of CQ, HCQ and their analogs in biological fluids using HPLC [8][9][10]. Determination of chloroquine and its decomposition products in various brands of different dosage forms are reported by few workers using LC and TLC [11]. Identification of a few impurities in chloroquine by GC-MS has been reported by Wenjin et al [12].…”

Section: Introductionmentioning

confidence: 98%

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR

Dongre

Ghugare

Karmuse

et al. 2009

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 98%

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR

Dongre

Ghugare

Karmuse

et al. 2009

Journal of Pharmaceutical and Biomedical Analysis

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“…On top of the reference official methods, many analytical methods; Spectrofluorimetry (Vogel and Konigk, 1975;Adelusi and Salako, 1980;Anbarasan et al, 2013), Spectrophotometry (Patel et al, 2005;Ofokansi et al, 2009;Aitha, 2013), HPLC (Vogel and Konigk, 1975;Chaulet et al, 1993;Abdelrahman et al, 1994;Walker and Ademowo, 1996;Paci et al, 2002;Patel et al, 2005;Samanidou et al, 2005), Gas chromatography (Bergquvist and Eckerbom, 1984), and Calorimetry (Kaseje and Brandling-Bennett, 1988) have been reported for determination of chloroquine phosphate from different dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Validated UV-Visible spectrometry using water as a solvent for determination of chloroquine in tablet samples

Int¹

2019

Preprint

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Methods reported including the official methods for determination ofchloroquine in tablet samples use carcinogenic organic solvents. In this study,UV-Vis spectrometry using water as a solvent was developed for determination ofchloroquine phosphate in pharmaceutical tablet dosage forms. The method wasvalidated according to the International Conference on Harmonization (ICH) andUSP guidelines. The absorbance of chloroquine phosphate in distilled water at max of 343 nm showed linear dependence on concentration in the range 10.88-30.56μg mL-1 with determination coefficient of 0.99972. Recovery results in the range98.79–101.20% and low coefficient of variation values for intra-day and interdayprecisions (0.37% and 0.76%, respectively) showed the accuracy andreproducibility of the method. The method was used for determination ofchloroquine phosphate in tablet formulations of different brands. Results in therange 100.63–103.52% of the labeled chloroquine phosphate in tabletformulations confirmed the applicability of the developed method for real sampleanalysis. Hence, the developed UV-Vis method using environmentally friendlywater as a solvent, with an excellent accuracy and precision showed that thedeveloped method can be a potential substituent for the official referencemethods.

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“…bCPQ is official in the US pharmacopeia, which contains a uv-spectrophotometric method [2]. In the open literature, few methods are found for the determination of CQP in pharmaceuticals and include titrimetry [4][5][6], gravimetry [7], potentiometry [8][9][10][11], spectrofluorimetry [12][13][14][15][16][17], uvspectrophotometry [18][19][20][21], HPLC [22][23][24][25][26][27][28][29][30][31][32], HPTLC [26] and bioassay [33].…”

Section: Introductionmentioning

confidence: 99%

Sensitive and Selective Extraction-Free Spectrophotometric Assay of Chloroquine Phosphate in Pharmaceuticals Based on Ion-Pair Reaction with Bromocresol Green and Bromocresol Purple

As¹,

Basavaiah²,

Swamy³

2017

Pharm Anal Acta

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Chloroquine Phosphate (CQP) is an antimalarial agent extensively used in the treatment of malaria. Two spectrophotometric methods, which are rapid, simple, selective and sensitive, are presented for the determination of CQP in bulk and dosage forms using two sulphonphthalein dyes: Bromocresol Green (BCG method) and Bromocresol Purple (BCP method). The methods are based on the formation of chloroform-soluble ion-pairs, when CQP is reacted with either dye, suitable for measurement at 420 nm in both the methods. The effects of reaction time, dye concentration and reaction medium were carefully studied and optimized. Under the optimum reaction conditions, Beer's law is obeyed overconcentration ranges 1-20 and 0.5-12 µg mL -1 CQP (base) for BCG method and BCP method respectively, with corresponding molar absorptivity values of 1.79 × 10 4 and 3.09 × 10 4 L mol -1 cm -1 . The calculated limits of detection (LOD) and quantification (LOQ) are 0.27 and 0.82 µg mL -1 (BCG method); 0.15 and 0.46 µg mL -1 (BCP method). Intra-day and inter-day %RSD values were ≤1.56% and ≤1.83% whereas the respective %RE values were better than 2%. Robustness of the methods was determined by performing analysis with slightly altered optimum conditions while ruggedness was tested by inter-personnel as well as inter-equipment variations; the %RSD values were within the accepted limits in both instances. Method selectivity was as ascertained by placebo blank and synthetic mixture analysis with no detectable interference from co-formulated substances in the assays. The methods were applied to the determination of CQP in tablets, suspension and injections with satisfactory results. Accuracy was also confirmed by recovery test via standard-addition procedure.

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Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography

Cited by 10 publications

References 2 publications

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR

Validated UV-Visible spectrometry using water as a solvent for determination of chloroquine in tablet samples

Sensitive and Selective Extraction-Free Spectrophotometric Assay of Chloroquine Phosphate in Pharmaceuticals Based on Ion-Pair Reaction with Bromocresol Green and Bromocresol Purple

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