Determination of chloroquine in blood by gas chromatography with nitrogen-selective detection using an internal standard

Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC–MS analysis

“…In general, gas chromatography and liquid chromatography have been used to separate drugs and non-retained compounds from each other and equipped with proper detector for their instrumental detection ( Kar, 2005 ). Chloroquine has been qualified/quantified by high performance liquid chromatography-ultraviolet detection (HPLC-UV) ( Cheomung & Na-Bangchang, 2011 ), high performance liquid chromatography-fluorescence detection (HPLC-FL) ( Samanidou, Evaggelopoulou, & Papadoyannis, 2005 ), gas chromatography (GC)‑nitrogen sensitive detector ( Churchill, Mount, & Schwartz, 1983 ; Viala, Deturmeny, Estadieu, Durand, & Cano, 1981 ), differential pulse voltammetry (DPV) ( Mashhadizadeh & Akbarian, 2009 ), liquid chromatography-tandem mass spectrometry (LC-MS/MS) ( Boonprasert, Sri-In, Pongnarin, Chatsiricharoenkul, & Chandranipapongse, 2012 ; Singhal et al, 2007 ), laser induced fluorescence ( Amador-Hernández, Fernández-Romero, & Luque De Castro, 2001 ), liquid chromatography/ion trap mass spectrometry (LC-IT-MS), liquid chromatography/time of flight mass spectrometry (LC-TOF-MS) and nuclear magnetic resonance (NMR) spectroscopy ( Dongre et al, 2009 ). Additionally, there is no many studies in literature for the determination of chloroquine by using GC instruments.…”