Determination of clindamycin in dosage forms and biological samples by adsorption stripping voltammetry with carbon paste electrode

Abstract

The electrochemical behavior of antibiotic drugs, clindamycin hydrochloride (I) and its phosphate salt (II), on carbon paste electrode (CPE) is thoroughly investigated. Chemical and electrical parameters affecting the adsorption stripping voltammetry (ASV) measurements are optimized. Two different modes of sweep, viz., differential pulse (DP) and square wave (SW), are compared over a potential range of +400 to +1100 mV in the presence of 0.04 M Britton -Robinson buffer (pH 10) with an accumulation time of 30 s, scan rate of 100 mV/s, and pulse amplitude of 30 mV. The responses are linear over a concentration range of 86 -430 and 90 -813 ng/ml for I and 86 -516 and 172 -1030 ng/ml for II in the DP and SW sweep modes, respectively. The limits of detection (with correlation coefficients given in brackets) are as follow (ng/ml): 32.60 (0.998) and 90.73 (0.994) for I and 43.51 (0.997) and 83.02 (0.996) for II in the DP and SW sweep modes, respectively. The DP method has been applied successfully to determining the active ingredients in pharmaceutical preparations and in spiked urine with mean percentage recoveries of 99.24 ± 2.14 and 98.66 ± 2.38, respectively.

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

“…128 The method was accurate, precise and successfully applied for determining the drug in pharmaceutical preparations (capsules and lotion) and in human urine samples. The usability of the imprinted sensor for determination of the drug in human urine samples was successfully evaluated.…”

A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin

“…For instance, clindamycin is a lincosamide antibiotic, which is widely used for the treatment of bacterial infections. The side effects of clindamycin include dry skin, nausea, vomiting, and constipation ( Liu et al, 2010 ; Habib et al, 2011 ; Girondi et al, 2018 ; Mohammad Beigi et al, 2020 ; Liang et al, 2021 ). Researchers are also highly concerned about the bacterial resistance of clindamycin due to its overuse.…”

Determination of CLINDAMYCIN HCl in Capsules by New, Validated, Simple and Green Kinetic Spectrometric Method

“…High-performance liquid chromatography (HPLC) is the most commonly used [2,[4][5][6][7][8][9], potentiometric determination [10] capillary electrophoresis [11], micellar chromatography [12], chemiluminescence methods [13], voltammetry [14][15][16] and Spectrophotometric determination that dependent on color forming [17][18].…”